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Peer-reviewedCC BY-NCBioImpacts : BI

Hydrogel-based smart bioinks for 3D bioprinting: design strategies and applications in brain tissue engineering and tumor microenvironment modelling.

  • Chintan Aundhia1
  • Jagruti Desai2
  • Swayamprakash Patel2
  • Chitrali Talele1
  • Bhupendra G Prajapati3
  1. 1Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat 391760, India.
  2. 2Department of Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT Campus, Changa 388421, India.
  3. 3Department of Pharmaceutics, Parul Institute of Pharmacy, Faculty of Pharmacy and Research & Development Cell, Parul University, Waghodia, Vadodara, Gujarat 391760, India.
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Abstract

Smart bioinks based on hydrogel have emerged a revolutionary platform in three-dimensional bioprinting that facilitates the development of biomimetic tissue constructs with a higher level of structural and biological precision. These advanced bioinks exhibit dynamic responsiveness to physicochemical and biological stimuli, allowing precise modulation of cell matrix interactions and microenvironmental conditions. The rational design of smart bioinks has achieved considerable advances in recent years by means of controlled optimization of rheological properties, crosslinking processes, and incorporation of bioactive agents. This review gives an in-depth account of hydrogel-based smart bioinks, their design principles, physicochemical and biological properties, and printability aspects. Their use in brain tissue engineering and tumor microenvironment modelling is of special interest as their capability to replicate complex cellular structures, biochemical gradients and dynamic signalling plays a critical role. Additionally, latest trends such as recent developments in nanocomposite bioinks, co-culture, and AI-assisted bio fabrication are also discussed. Although significant advances have been made, vascularization issues, long-term functionality, and scalability issues continue to pose major barriers to clinical translation. Altogether, hydrogel-based smart bioinks may be viewed as a promising approach to the development of tissue engineering, disease modelling, and precision medicine applications.

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Cite

BibTeXRIS
BibTeX
@article{aundhia2026hydrogelbased,
  title = {{Hydrogel-based smart bioinks for 3D bioprinting: design strategies and applications in brain tissue engineering and tumor microenvironment modelling.}},
  author = {Chintan Aundhia and Jagruti Desai and Swayamprakash Patel and Chitrali Talele and Bhupendra G Prajapati},
  journal = {BioImpacts : BI},
  year = {2026},
  month = aug,
  doi = {10.34172/bi.33650},
  url = {https://europepmc.org/article/MED/42898419},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Hydrogel-based smart bioinks for 3D bioprinting: design strategies and applications in brain tissue engineering and tumor microenvironment modelling.
AU  - Chintan Aundhia
AU  - Jagruti Desai
AU  - Swayamprakash Patel
AU  - Chitrali Talele
AU  - Bhupendra G Prajapati
PY  - 2026
DA  - 2026/08/16
JO  - BioImpacts : BI
DO  - 10.34172/bi.33650
UR  - https://europepmc.org/article/MED/42898419
AB  - Smart bioinks based on hydrogel have emerged a revolutionary platform in three-dimensional bioprinting that facilitates the development of biomimetic tissue constructs with a higher level of structural and biological precision. These advanced bioinks exhibit dynamic responsiveness to physicochemical and biological stimuli, allowing precise modulation of cell matrix interactions and microenvironmental conditions. The rational design of smart bioinks has achieved considerable advances in recent years by means of controlled optimization of rheological properties, crosslinking processes, and incorporation of bioactive agents. This review gives an in-depth account of hydrogel-based smart bioinks, their design principles, physicochemical and biological properties, and printability aspects. Their use in brain tissue engineering and tumor microenvironment modelling is of special interest as their capability to replicate complex cellular structures, biochemical gradients and dynamic signalling plays a critical role. Additionally, latest trends such as recent developments in nanocomposite bioinks, co-culture, and AI-assisted bio fabrication are also discussed. Although significant advances have been made, vascularization issues, long-term functionality, and scalability issues continue to pose major barriers to clinical translation. Altogether, hydrogel-based smart bioinks may be viewed as a promising approach to the development of tissue engineering, disease modelling, and precision medicine applications.
SN  - 2228-5652
SN  - 2228-5660
ER  -