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Peer-reviewedCC BY-NC-NDNature Neuroscience

Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks

  • Satoka H. Fujimoto1,2,3,4,5,6
  • Atsushi Fujimoto7,8,9,4,5,6
  • Catherine Elorette8,9,4,5,6
  • Adela Seltzer8,9,4,5,6
  • Emma Andraka8,9,4,5,6
  • Keondre Herbert8,9,10,11,12
  • Gaurav Verma13,14,5,15
  • William G.M. Janssen9,10,12
  • Lazar Fleysher13,4,5,6
  • Davide Folloni8,9,10,11,12
  • Ki Sueng Choi13,14,16,17,5,15,18
  • Brian Edward Russ19,20,9,11,5,15
2 more authors
  • Helen S. Mayberg14,9,4,5,6
  • Peter H. Rudebeck21,22
22 affiliations
  1. 1Department of Neuroscience and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA. [email protected]
  2. 2Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [email protected]
  3. 3Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [email protected]
  4. 4Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai
  5. 5Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
  6. 6New York, NY 1009, USA
  7. 7Department of Neuroscience and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA
  8. 8Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  9. 9Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  10. 10BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai
  11. 11Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital
  12. 12New York, NY 10029, USA
  13. 13BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  14. 14Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital, New York, NY, USA
  15. 15New York, NY 0029, USA
  16. 16Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute
  17. 17Department of Psychiatry, New York University at Langone
  18. 18Orangeburg, NY 10962, USA
  19. 19Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, USA
  20. 20Department of Psychiatry, New York University at Langone, New York, NY, USA
  21. 21Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [email protected]
  22. 22Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [email protected]
Open at sourceDOICite

Abstract

Deep brain stimulation (DBS) is an emerging therapeutic option for treatment resistant neurological and psychiatric disorders, most notably depression. Despite this, little is known about the anatomical and functional mechanisms that underlie this therapy. Here we targeted stimulation to the white matter adjacent to the subcallosal anterior cingulate cortex (SCC-DBS) in macaques, modeling the location in the brain proven effective for depression. We demonstrate that SCC-DBS has a selective effect on white matter macro- and micro-structure in the cingulum bundle distant to where stimulation was delivered. SCC-DBS also decreased functional connectivity between subcallosal and posterior cingulate cortex, two areas linked by the cingulum bundle and implicated in depression. Our data reveal that white matter remodeling as well as functional effects contribute to DBS’s therapeutic efficacy.

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Cite

BibTeXRIS
BibTeX
@article{fujimoto2026deep,
  title = {{Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks}},
  author = {Satoka H. Fujimoto and Atsushi Fujimoto and Catherine Elorette and Adela Seltzer and Emma Andraka and Keondre Herbert and Gaurav Verma and William G.M. Janssen and Lazar Fleysher and Davide Folloni and Ki Sueng Choi and Brian Edward Russ and Helen S. Mayberg and Peter H. Rudebeck},
  journal = {Nature Neuroscience},
  year = {2026},
  month = jun,
  doi = {10.1038/s41593-026-02301-4},
  url = {https://doi.org/10.1038/s41593-026-02301-4},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks
AU  - Satoka H. Fujimoto
AU  - Atsushi Fujimoto
AU  - Catherine Elorette
AU  - Adela Seltzer
AU  - Emma Andraka
AU  - Keondre Herbert
AU  - Gaurav Verma
AU  - William G.M. Janssen
AU  - Lazar Fleysher
AU  - Davide Folloni
AU  - Ki Sueng Choi
AU  - Brian Edward Russ
AU  - Helen S. Mayberg
AU  - Peter H. Rudebeck
PY  - 2026
DA  - 2026/06/01
JO  - Nature Neuroscience
DO  - 10.1038/s41593-026-02301-4
UR  - https://doi.org/10.1038/s41593-026-02301-4
AB  - Deep brain stimulation (DBS) is an emerging therapeutic option for treatment resistant neurological and psychiatric disorders, most notably depression. Despite this, little is known about the anatomical and functional mechanisms that underlie this therapy. Here we targeted stimulation to the white matter adjacent to the subcallosal anterior cingulate cortex (SCC-DBS) in macaques, modeling the location in the brain proven effective for depression. We demonstrate that SCC-DBS has a selective effect on white matter macro- and micro-structure in the cingulum bundle distant to where stimulation was delivered. SCC-DBS also decreased functional connectivity between subcallosal and posterior cingulate cortex, two areas linked by the cingulum bundle and implicated in depression. Our data reveal that white matter remodeling as well as functional effects contribute to DBS’s therapeutic efficacy.
SN  - 1097-6256
SN  - 1546-1726
ER  -