Bone quality deterioration is accompanied by mesenchymal stem cell defects in osteoporosis patients undergoing spinal fusion.
- 1Medicine School, Changsha Social Work College, Changsha, Hunan 410004, China.
- 2Department of Spine Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
- 3National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Abstract
As the elderly population grows, the number of osteoporosis (OP) patients undergoing spinal fusion has been increasing, and they often require more postoperative revision. Our research aims to examine the health status of autologous bone grafts and bone marrow mesenchymal stem cells (BMSCs) in patients with OP, in order to prevent postoperative complications. Cancellous bone specimens from spinous processes were obtained from 54 aging patients (OP and non-OP groups, n = 27 for each) during lumbar fusion surgery. In addition, BMSCs were harvested from vertebral bodies of 28 of the 54 patients (20 postmenopausal women and 8 men older than 50 yr-of-age). Bone microstructure was measured using micro-CT. Bone marrow mesenchymal stem cell number, proliferation capacity, and osteogenic and adipogenic potential were evaluated in vitro. Compared to non-OP subjects, less bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and higher structure model indices were noted in the OP group. In addition, decreased BMSCs and proliferative capacity and osteogenic potential occurred in the OP group. The adipogenic potential of BMSCs was not clear. Total BMD of the LS was positively correlated with proliferative capacity and the osteogenic differentiation potential of BMSCs. In summary, bone quality deterioration is accompanied by quantitative and qualitative defects of BMSCs in OP patients undergoing bone fusion. Total BMD of the LS (L1-L4) as measured using DXA may predict BMSC proliferative capacity and osteogenic potential.
Related
- Resting-state electroencephalographic characteristics in patients with atopic dermatitis accompanied by chronic pruritus
- Gut microbiota-derived tryptophan metabolites and inflammatory factors enhance prediction of early neurological deterioration after intravenous thrombolysis in stroke patients: a comparative model study
- A Transosseous Suture Technique for Rotator Cuff Repair in Patients With Severe Osteoporosis.
- Intraglandular treatment with adipose-derived mesenchymal stem cells in patients with xerostomia due to Sjögren’s disease—a study protocol for aphase 1, triple-blinded, randomized, clinical trial
- Influenza-associated acute respiratory deterioration fulfilling acute exacerbation criteria in hospitalized patients with interstitial lung disease: a single-center retrospective cohort study
BibTeX
@article{xie2026bone,
title = {{Bone quality deterioration is accompanied by mesenchymal stem cell defects in osteoporosis patients undergoing spinal fusion.}},
author = {Fen Xie and Bin Zhou and Yuling Liu and Jian Wang and Qiongfei Zhou and Yuhang Hu and Yijun Kang and Ruchun Dai},
journal = {JBMR plus},
year = {2026},
month = oct,
doi = {10.1093/jbmrpl/ziag161},
url = {https://europepmc.org/article/MED/42928910},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Bone quality deterioration is accompanied by mesenchymal stem cell defects in osteoporosis patients undergoing spinal fusion.
AU - Fen Xie
AU - Bin Zhou
AU - Yuling Liu
AU - Jian Wang
AU - Qiongfei Zhou
AU - Yuhang Hu
AU - Yijun Kang
AU - Ruchun Dai
PY - 2026
DA - 2026/10/06
JO - JBMR plus
DO - 10.1093/jbmrpl/ziag161
UR - https://europepmc.org/article/MED/42928910
AB - As the elderly population grows, the number of osteoporosis (OP) patients undergoing spinal fusion has been increasing, and they often require more postoperative revision. Our research aims to examine the health status of autologous bone grafts and bone marrow mesenchymal stem cells (BMSCs) in patients with OP, in order to prevent postoperative complications. Cancellous bone specimens from spinous processes were obtained from 54 aging patients (OP and non-OP groups, n = 27 for each) during lumbar fusion surgery. In addition, BMSCs were harvested from vertebral bodies of 28 of the 54 patients (20 postmenopausal women and 8 men older than 50 yr-of-age). Bone microstructure was measured using micro-CT. Bone marrow mesenchymal stem cell number, proliferation capacity, and osteogenic and adipogenic potential were evaluated in vitro. Compared to non-OP subjects, less bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and higher structure model indices were noted in the OP group. In addition, decreased BMSCs and proliferative capacity and osteogenic potential occurred in the OP group. The adipogenic potential of BMSCs was not clear. Total BMD of the LS was positively correlated with proliferative capacity and the osteogenic differentiation potential of BMSCs. In summary, bone quality deterioration is accompanied by quantitative and qualitative defects of BMSCs in OP patients undergoing bone fusion. Total BMD of the LS (L1-L4) as measured using DXA may predict BMSC proliferative capacity and osteogenic potential.
SN - 2473-4039
ER -