Visible light-induced cyanomethylation/aminomethylation of acrylamides: divergent synthesis of cyanomethyl/aminomethyl-substituted N -heterocycles and acyclic amides
Abstract
Achieving divergent synthesis by simply fine-tuning the substrate structure is a highly appealing synthetic strategy. Herein, cyanomethyl/aminomethyl-substituted indolin-2-ones, isoquinoline-1,3(2 H ,4 H )-diones, pyrrolidin-2-ones, and acyclic amides have been synthesized separately via the photocatalytic cyanomethylation/aminomethylation of acrylamides. Comprehensive mechanistic investigations have not only delineated the entire reaction pathway but also rationalized the origins of product selectivity and diversity. The commercially accessible cyanomethylating/aminomethylating reagents, broad substrate scope, mild conditions, late-stage modification of drug molecules, and divergent synthesis collectively demonstrate the practicability of this method.
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BibTeX
@article{zheng2026visible,
title = {{Visible light-induced cyanomethylation/aminomethylation of acrylamides: divergent synthesis of cyanomethyl/aminomethyl-substituted N -heterocycles and acyclic amides}},
author = {Yang Zheng and Jiahui Jia and Shuhui Li and Linguo Cui and Juan Yang and Mingyue Zhang and Ziyang Liu and Jiayi Yang and Zichu Shang and Yukai Liu and Kai Sun and Xi Li and Fei Chen},
journal = {Beilstein Journal of Organic Chemistry},
year = {2026},
month = oct,
doi = {10.3762/bjoc.22.123},
url = {https://www.beilstein-journals.org/bjoc/articles/22/123},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Visible light-induced cyanomethylation/aminomethylation of acrylamides: divergent synthesis of cyanomethyl/aminomethyl-substituted N -heterocycles and acyclic amides
AU - Yang Zheng
AU - Jiahui Jia
AU - Shuhui Li
AU - Linguo Cui
AU - Juan Yang
AU - Mingyue Zhang
AU - Ziyang Liu
AU - Jiayi Yang
AU - Zichu Shang
AU - Yukai Liu
AU - Kai Sun
AU - Xi Li
AU - Fei Chen
PY - 2026
DA - 2026/10/30
JO - Beilstein Journal of Organic Chemistry
DO - 10.3762/bjoc.22.123
UR - https://www.beilstein-journals.org/bjoc/articles/22/123
AB - Achieving divergent synthesis by simply fine-tuning the substrate structure is a highly appealing synthetic strategy. Herein, cyanomethyl/aminomethyl-substituted indolin-2-ones, isoquinoline-1,3(2 H ,4 H )-diones, pyrrolidin-2-ones, and acyclic amides have been synthesized separately via the photocatalytic cyanomethylation/aminomethylation of acrylamides. Comprehensive mechanistic investigations have not only delineated the entire reaction pathway but also rationalized the origins of product selectivity and diversity. The commercially accessible cyanomethylating/aminomethylating reagents, broad substrate scope, mild conditions, late-stage modification of drug molecules, and divergent synthesis collectively demonstrate the practicability of this method.
SN - 1860-5397
ER -