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Peer-reviewedCC BY 4.0Journal of Reproductive Immunology

Presence of fetal intervillous cells in a case of chronic placental inflammation

  • A Remoué
  • C de Moreuil
  • S Herrmann
  • K Morcel
  • B Pan Petesch
  • A Uguen
  • P Marcorelles
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Abstract

Chronic Histiocytic Intervillositis (CHI) is a rare and severe histological entity. We explored the origin of the intervillous cells with a Fluorescence In Situ Hybridization (FISH) XY probe on cases concerned by an intervillositis diagnosed between 2014 and 2023 involving male fetuses, focusing on cases with fetal complications and/or high-grade CHI. Six cases showed maternal intervillous cells, in accordance with the hypothesis of an allograft rejection reaction. One case showed a predominance of fetal intervillous cells. We suggest that it could be an excess of fetal microchimerism, possibly exacerbated by trophoblast damage and excessive inflammation in placenta.

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Cite

BibTeXRIS
BibTeX
@article{remoue2026presence,
  title = {{Presence of fetal intervillous cells in a case of chronic placental inflammation}},
  author = {A Remoué and C de Moreuil and S Herrmann and K Morcel and B Pan Petesch and A Uguen and P Marcorelles},
  journal = {Journal of Reproductive Immunology},
  year = {2026},
  month = sep,
  doi = {10.1016/j.jri.2025.104794},
  url = {https://univ-brest.hal.science/hal-05735339v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Presence of fetal intervillous cells in a case of chronic placental inflammation
AU  - A Remoué
AU  - C de Moreuil
AU  - S Herrmann
AU  - K Morcel
AU  - B Pan Petesch
AU  - A Uguen
AU  - P Marcorelles
PY  - 2026
DA  - 2026/09/02
JO  - Journal of Reproductive Immunology
DO  - 10.1016/j.jri.2025.104794
UR  - https://univ-brest.hal.science/hal-05735339v1
AB  - Chronic Histiocytic Intervillositis (CHI) is a rare and severe histological entity. We explored the origin of the intervillous cells with a Fluorescence In Situ Hybridization (FISH) XY probe on cases concerned by an intervillositis diagnosed between 2014 and 2023 involving male fetuses, focusing on cases with fetal complications and/or high-grade CHI. Six cases showed maternal intervillous cells, in accordance with the hypothesis of an allograft rejection reaction. One case showed a predominance of fetal intervillous cells. We suggest that it could be an excess of fetal microchimerism, possibly exacerbated by trophoblast damage and excessive inflammation in placenta.
SN  - 0165-0378
ER  -