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Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

VvGAMYB Orchestrates Multi-Signaling Networks to Modulate GA-Induced Parthenocarpic Seedless Berry Development in Grapes

  • Qiqi Wu1
  • Ruiqiang Chao1
  • Linjia Luo1
  • Yuqing Huang1
  • Jing Li1
  • Lianshuang Liang1
  • Xuxian Xuan1
  • Yanan Liu1
  • Xinpeng Chen1
  • Xicheng Wang2
  • Chen Wang1
  1. 1College of Horticulture, Nanjing Agricultural University, Nanjing 211800, China
  2. 2Institute of Pomology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China
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Abstract

Exogenous gibberellin (GA) efficiently induces seeded grape parthenocarpy and improves berry quality, with VvGAMYB serving as a key response factor. However, the VvGAMYB-mediated regulatory networks underlying this process remain unclear. In this study, GA3 treatment induced ovule abortion in ‘Wink’ grape, leading to the formation of parthenocarpic seedless berries. Exogenous GA drastically repressed VvGAMYB levels, thereby promoting parthenocarpy in grape ovaries. Through protein interaction screening, we identified 181 predicted VvGAMYB-associated proteins, which include differentially expressed genes related to hormone signaling, sugar metabolism, and transcriptional regulation, and further revealed that GA-induced grape parthenocarpy likely operates through a VvGAMYB-mediated network, coordinating key genes such as VvGID1B (GA signaling), VvRAP2-4 (ETH signaling), VvGAPC2 (glycolysis), and VvMETKs (methylation modification). Among these candidates, VvGAMYB repressed VvMETK2 promoter activity, whereas GA3 treatment weakened this repression, as demonstrated by a dual-luciferase assay in tobacco. Collectively, this study established an integrative framework in which VvGAMYB orchestrates phytohormone crosstalk, sugar metabolism, and epigenetic modification during GA-induced parthenocarpy. Our findings provide significant insights into the molecular network of GA-induced grape parthenocarpy and offer key target genes for the molecular breeding of high-quality seedless grapes.

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Cite

BibTeXRIS
BibTeX
@article{wu2026vvgamyb,
  title = {{VvGAMYB Orchestrates Multi-Signaling Networks to Modulate GA-Induced Parthenocarpic Seedless Berry Development in Grapes}},
  author = {Qiqi Wu and Ruiqiang Chao and Linjia Luo and Yuqing Huang and Jing Li and Lianshuang Liang and Xuxian Xuan and Yanan Liu and Xinpeng Chen and Xicheng Wang and Chen Wang},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27198828},
  url = {https://www.mdpi.com/1422-0067/27/19/8828},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - VvGAMYB Orchestrates Multi-Signaling Networks to Modulate GA-Induced Parthenocarpic Seedless Berry Development in Grapes
AU  - Qiqi Wu
AU  - Ruiqiang Chao
AU  - Linjia Luo
AU  - Yuqing Huang
AU  - Jing Li
AU  - Lianshuang Liang
AU  - Xuxian Xuan
AU  - Yanan Liu
AU  - Xinpeng Chen
AU  - Xicheng Wang
AU  - Chen Wang
PY  - 2026
DA  - 2026/10/02
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27198828
UR  - https://www.mdpi.com/1422-0067/27/19/8828
AB  - Exogenous gibberellin (GA) efficiently induces seeded grape parthenocarpy and improves berry quality, with VvGAMYB serving as a key response factor. However, the VvGAMYB-mediated regulatory networks underlying this process remain unclear. In this study, GA3 treatment induced ovule abortion in ‘Wink’ grape, leading to the formation of parthenocarpic seedless berries. Exogenous GA drastically repressed VvGAMYB levels, thereby promoting parthenocarpy in grape ovaries. Through protein interaction screening, we identified 181 predicted VvGAMYB-associated proteins, which include differentially expressed genes related to hormone signaling, sugar metabolism, and transcriptional regulation, and further revealed that GA-induced grape parthenocarpy likely operates through a VvGAMYB-mediated network, coordinating key genes such as VvGID1B (GA signaling), VvRAP2-4 (ETH signaling), VvGAPC2 (glycolysis), and VvMETKs (methylation modification). Among these candidates, VvGAMYB repressed VvMETK2 promoter activity, whereas GA3 treatment weakened this repression, as demonstrated by a dual-luciferase assay in tobacco. Collectively, this study established an integrative framework in which VvGAMYB orchestrates phytohormone crosstalk, sugar metabolism, and epigenetic modification during GA-induced parthenocarpy. Our findings provide significant insights into the molecular network of GA-induced grape parthenocarpy and offer key target genes for the molecular breeding of high-quality seedless grapes.
SN  - 1422-0067
ER  -