Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?

Abstract

The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. Could a key role of gray-matter oligodendrocytes—activity-dependent adaptive myelination to sustain changes in activity—be perturbed, leading to cognitive loss?

The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. This Perspective suggests that activity-dependent adaptive myelination, a key role of grey-matter oligodendrocytes, could be perturbed, leading to cognitive loss.

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BibTeX RIS

BibTeX

@article{ffrenchconstant2026does,
  title = {{Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?}},
  author = {Charles ffrench-Constant},
  journal = {PLOS Biology},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pbio.3004033},
  url = {https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004033},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer’s disease?
AU  - Charles ffrench-Constant
PY  - 2026
DA  - 2026/10/12
JO  - PLOS Biology
DO  - 10.1371/journal.pbio.3004033
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004033
AB  - The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. Could a key role of gray-matter oligodendrocytes—activity-dependent adaptive myelination to sustain changes in activity—be perturbed, leading to cognitive loss?  The consequences of oligodendrocyte involvement in Alzheimer’s disease are poorly understood. This Perspective suggests that activity-dependent adaptive myelination, a key role of grey-matter oligodendrocytes, could be perturbed, leading to cognitive loss.
SN  - 1545-7885
ER  -

Abstract

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