Associations of Plasma Deoxycholic Acid and Its Conjugates With the Clinical Outcomes After Ischemic Stroke
- 1Department of Epidemiology, the Affiliated Guangji Hospital of Soochow University, School of Public Health Suzhou Medical College of Soochow University Suzhou Jiangsu China
- 2School of Nursing Suzhou Medical College of Soochow University Suzhou China
Abstract
Background: Deoxycholic acid (DCA) and its conjugates glycodeoxycholic acid (GDCA), taurodeoxycholic acid, and 23‐nordeoxycholic acid (NorDCA) were implicated in anti‐inflammation and energy metabolism, but their prognostic values in ischemic stroke remained unclear. We aimed to investigate the associations of plasma DCA and its conjugates with outcomes after ischemic stroke in a multicenter prognostic cohort study.
Methods: Our multicenter prognostic cohort study included 3405 Chinese patients with hypertensive stroke from the China Antihypertensive Trial in Acute Ischemic Stroke. The primary outcome was a composite outcome of death and major disability (modified Rankin Scale score, 3–6) at 3 months after ischemic stroke.
Results: After adjustment for age, sex, and other important covariates, elevated plasma DCA (odds ratio [OR], 0.65 [95% CI, 0.53–0.80]), GDCA (OR, 0.76 [95% CI, 0.61–0.93]), and NorDCA (OR, 0.73 [95% CI, 0.59–0.89]) were associated with a decreased risk of primary outcome when 2 extreme tertiles were compared. Multiple‐adjusted spline regression model showed linear associations of DCA, GDCA, and NorDCA with the primary outcome (all P value for linearity<0.05). Adding DCA, GDCA, NorDCA, or DCA metabolite score to conventional prognostic factors significantly improved the risk reclassification for the primary outcome, as evidenced by net reclassification improvement and integrated discrimination index (all P<0.05).
Conclusions: High DCA, GDCA, and NorDCA at baseline were associated with decreased risks of adverse outcomes at 3 months after ischemic stroke, indicating that DCA, GDCA, and NorDCA might be implicated in the development of ischemic stroke and could be valuable intervention targets for ischemic stroke.
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BibTeX
@article{qin2026associations,
title = {{Associations of Plasma Deoxycholic Acid and Its Conjugates With the Clinical Outcomes After Ischemic Stroke}},
author = {Xiaoli Qin and Quan Yu and Beiping Song and Jiawen Fei and Lingxiang Ye and Yanhen Guo and Daoxia Guo and Mengyao Shi and Aili Wang and Tan Xu and Yonghong Zhang and Zhengbao Zhu},
journal = {Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease},
year = {2026},
month = sep,
doi = {10.1161/jaha.125.048565},
url = {https://doi.org/10.1161/jaha.125.048565},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Associations of Plasma Deoxycholic Acid and Its Conjugates With the Clinical Outcomes After Ischemic Stroke
AU - Xiaoli Qin
AU - Quan Yu
AU - Beiping Song
AU - Jiawen Fei
AU - Lingxiang Ye
AU - Yanhen Guo
AU - Daoxia Guo
AU - Mengyao Shi
AU - Aili Wang
AU - Tan Xu
AU - Yonghong Zhang
AU - Zhengbao Zhu
PY - 2026
DA - 2026/09/09
JO - Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
DO - 10.1161/jaha.125.048565
UR - https://doi.org/10.1161/jaha.125.048565
AB - Background: Deoxycholic acid (DCA) and its conjugates glycodeoxycholic acid (GDCA), taurodeoxycholic acid, and 23‐nordeoxycholic acid (NorDCA) were implicated in anti‐inflammation and energy metabolism, but their prognostic values in ischemic stroke remained unclear. We aimed to investigate the associations of plasma DCA and its conjugates with outcomes after ischemic stroke in a multicenter prognostic cohort study. Methods: Our multicenter prognostic cohort study included 3405 Chinese patients with hypertensive stroke from the China Antihypertensive Trial in Acute Ischemic Stroke. The primary outcome was a composite outcome of death and major disability (modified Rankin Scale score, 3–6) at 3 months after ischemic stroke. Results: After adjustment for age, sex, and other important covariates, elevated plasma DCA (odds ratio [OR], 0.65 [95% CI, 0.53–0.80]), GDCA (OR, 0.76 [95% CI, 0.61–0.93]), and NorDCA (OR, 0.73 [95% CI, 0.59–0.89]) were associated with a decreased risk of primary outcome when 2 extreme tertiles were compared. Multiple‐adjusted spline regression model showed linear associations of DCA, GDCA, and NorDCA with the primary outcome (all P value for linearity<0.05). Adding DCA, GDCA, NorDCA, or DCA metabolite score to conventional prognostic factors significantly improved the risk reclassification for the primary outcome, as evidenced by net reclassification improvement and integrated discrimination index (all P<0.05). Conclusions: High DCA, GDCA, and NorDCA at baseline were associated with decreased risks of adverse outcomes at 3 months after ischemic stroke, indicating that DCA, GDCA, and NorDCA might be implicated in the development of ischemic stroke and could be valuable intervention targets for ischemic stroke.
SN - 2047-9980
ER -