Previously Undescribed Esters and an Alkaloid From Trollius chinensis With Anti-Inflammatory and Cytotoxic Activities.
- 1Department of Pharmacy, Shanghai Ninth People Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
- 2College of Clinical Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract
In this study, ten previously undescribed compounds, including nine esters (1-9) and one alkaloid (10), are isolated from the flowers of Trollius chinensis Bunge as part of an ongoing investigation into biologically active natural products with diverse structures. The structures and absolute configurations of the isolated compounds are determined based on extensive spectroscopic analyses, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) spectroscopy. In vitro assays are conducted to evaluate the inhibitory effects of the compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages and their cytotoxicity against HeLa, HepG2, and HCT 116 cell lines.
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BibTeX
@article{guo2026previously,
title = {{Previously Undescribed Esters and an Alkaloid From Trollius chinensis With Anti-Inflammatory and Cytotoxic Activities.}},
author = {Mei-Li Guo and Ya-Ting Yu and Hui-Bo Lei and Zhong-An Mao and Rong Wang and Yu-Jie Wang and Yong-Fang Yuan},
journal = {Chemistry \& biodiversity},
year = {2026},
month = oct,
doi = {10.1002/cbdv.71887},
url = {https://europepmc.org/article/MED/42960691},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Previously Undescribed Esters and an Alkaloid From Trollius chinensis With Anti-Inflammatory and Cytotoxic Activities.
AU - Mei-Li Guo
AU - Ya-Ting Yu
AU - Hui-Bo Lei
AU - Zhong-An Mao
AU - Rong Wang
AU - Yu-Jie Wang
AU - Yong-Fang Yuan
PY - 2026
DA - 2026/10/30
JO - Chemistry & biodiversity
DO - 10.1002/cbdv.71887
UR - https://europepmc.org/article/MED/42960691
AB - In this study, ten previously undescribed compounds, including nine esters (1-9) and one alkaloid (10), are isolated from the flowers of Trollius chinensis Bunge as part of an ongoing investigation into biologically active natural products with diverse structures. The structures and absolute configurations of the isolated compounds are determined based on extensive spectroscopic analyses, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) spectroscopy. In vitro assays are conducted to evaluate the inhibitory effects of the compounds on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages and their cytotoxicity against HeLa, HepG2, and HCT 116 cell lines.
SN - 1612-1872
SN - 1612-1880
ER -