A bibliometric and knowledge-mapping analysis of bladder cancer organoid research based on Web of Science, Scopus, and PubMed.
- 1Department of Urology, Affiliated Hospital of Southwest Medical University, Luzhou, China.
- 2Department of Urology, Western Theater Command General Hospital, Chengdu, China.
Abstract
Bladder cancer organoid research has grown rapidly in recent years, extending from model establishment to drug screening, precision medicine, and tumor microenvironment modeling. However, publication output, knowledge sources, collaboration patterns, and topic evolution in this area have not been systematically examined. This study aimed to conduct a bibliometric analysis and knowledge mapping of bladder cancer organoid research, with an independent Medical Literature Analysis and Retrieval System Online (MEDLINE) search conducted through PubMed to assess annual trends and thematic results. Web of Science Core Collection and Scopus were used as the primary data sources. English-language Articles and Reviews related to bladder cancer or urothelial carcinoma organoid research published from 2015 to May 20, 2026, were retrieved. Records from the two databases were converted, standardized, and deduplicated to form the main analytical dataset. The MEDLINE database was searched through PubMed with an equivalent strategy and, after the same document-type and language restrictions, was used as an independent supplementary dataset for annual trend and subject-term comparisons. Python was used for data preprocessing, and R/bibliometrix, CiteSpace, and VOSviewer were used to analyze annual trends, country/region and institutional collaboration, author and journal influence, citation bursts, keyword co-occurrence, clustering, and trend topics. The main Web of Science-Scopus dataset included 263 publications from 38 countries/regions, 365 institutions, 2,021 authors, and 168 journals or publication sources, with 8,593 total citations. Annual publication output increased quickly after 2019, and 2025 was the most productive complete publication year. China and the United States were the leading production centers, while the United States also showed a relatively high proportion of international collaboration. Highly cited publications and citation burst results identified patient-derived bladder cancer organoids, urothelial cancer-specific models, bladder assembloids, and tumor microenvironment modeling as major knowledge sources in the field. Keyword analysis showed that bladder cancer and organoid formed the dual core of the network, while drug screening, precision medicine, patient-derived organoid (PDO), drug resistance, immunotherapy, and antibody-drug conjugate became more active in recent years. The supplementary MEDLINE dataset contained 181 screened records, and its annual growth pattern and main themes were broadly consistent with the main analytical results. Bladder cancer organoid research is moving from early model establishment and molecular characterization toward functional drug screening, precision medicine, tumor microenvironment modeling, and treatment response evaluation. Future studies should strengthen multicenter collaboration, model standardization, consistency of drug-sensitivity readouts, integration of immune and stromal components, and validation of associations between organoid-derived findings and clinical outcomes.
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BibTeX
@article{li2026bibliometric,
title = {{A bibliometric and knowledge-mapping analysis of bladder cancer organoid research based on Web of Science, Scopus, and PubMed.}},
author = {Zhanyuan Li and Yaoyu Zhang and Xiaodong Li and Haofeng Li and Kewei Xiang and Shadan Li},
journal = {Translational andrology and urology},
year = {2026},
month = sep,
doi = {10.21037/tau-2026-0528},
url = {https://europepmc.org/article/MED/42997143},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - A bibliometric and knowledge-mapping analysis of bladder cancer organoid research based on Web of Science, Scopus, and PubMed.
AU - Zhanyuan Li
AU - Yaoyu Zhang
AU - Xiaodong Li
AU - Haofeng Li
AU - Kewei Xiang
AU - Shadan Li
PY - 2026
DA - 2026/09/28
JO - Translational andrology and urology
DO - 10.21037/tau-2026-0528
UR - https://europepmc.org/article/MED/42997143
AB - Bladder cancer organoid research has grown rapidly in recent years, extending from model establishment to drug screening, precision medicine, and tumor microenvironment modeling. However, publication output, knowledge sources, collaboration patterns, and topic evolution in this area have not been systematically examined. This study aimed to conduct a bibliometric analysis and knowledge mapping of bladder cancer organoid research, with an independent Medical Literature Analysis and Retrieval System Online (MEDLINE) search conducted through PubMed to assess annual trends and thematic results. Web of Science Core Collection and Scopus were used as the primary data sources. English-language Articles and Reviews related to bladder cancer or urothelial carcinoma organoid research published from 2015 to May 20, 2026, were retrieved. Records from the two databases were converted, standardized, and deduplicated to form the main analytical dataset. The MEDLINE database was searched through PubMed with an equivalent strategy and, after the same document-type and language restrictions, was used as an independent supplementary dataset for annual trend and subject-term comparisons. Python was used for data preprocessing, and R/bibliometrix, CiteSpace, and VOSviewer were used to analyze annual trends, country/region and institutional collaboration, author and journal influence, citation bursts, keyword co-occurrence, clustering, and trend topics. The main Web of Science-Scopus dataset included 263 publications from 38 countries/regions, 365 institutions, 2,021 authors, and 168 journals or publication sources, with 8,593 total citations. Annual publication output increased quickly after 2019, and 2025 was the most productive complete publication year. China and the United States were the leading production centers, while the United States also showed a relatively high proportion of international collaboration. Highly cited publications and citation burst results identified patient-derived bladder cancer organoids, urothelial cancer-specific models, bladder assembloids, and tumor microenvironment modeling as major knowledge sources in the field. Keyword analysis showed that bladder cancer and organoid formed the dual core of the network, while drug screening, precision medicine, patient-derived organoid (PDO), drug resistance, immunotherapy, and antibody-drug conjugate became more active in recent years. The supplementary MEDLINE dataset contained 181 screened records, and its annual growth pattern and main themes were broadly consistent with the main analytical results. Bladder cancer organoid research is moving from early model establishment and molecular characterization toward functional drug screening, precision medicine, tumor microenvironment modeling, and treatment response evaluation. Future studies should strengthen multicenter collaboration, model standardization, consistency of drug-sensitivity readouts, integration of immune and stromal components, and validation of associations between organoid-derived findings and clinical outcomes.
SN - 2223-4691
ER -