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Peer-reviewedCC BY-NC 4.0International Journal of Nanomedicine

MiR-302c-3p-Encapsulated Cationic TAmP PCEC Hydrogels for Targeted ADAMTS5 Suppression and Osteoarthritis Treatment

  • Yuzhou Zhao1
  • Yongheng Ye2
  • Tianyu Zhao3
  • Zeyang Yao1
  • Yong Liu1
  • Dianbo Long1
  • Jianhua Liu1
  • Xiaoyi Zhao1
  • Peiheng He1
  1. 1Department of Joint Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
  2. 2Department of Joint Surgery and Sports Medicine, Zhuhai People’s Hospital, Zhuhai, Guangdong, People’s Republic of China
  3. 3School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
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Abstract

Introduction: Osteoarthritis (OA) remains a degenerative joint disorder with limited treatment options.

Methods: We examined miR-302c-3p expression in human OA cartilage and primary chondrocytes, validated ADAMTS5 as a direct target, and developed a PCEC/TAmP hydrogel for intra-articular delivery in a DMM mouse model.

Results: miR-302c-3p was downregulated in OA cartilage and attenuated IL-1β-induced chondrocyte catabolism by reducing ADAMTS5, MMP1, and MMP13 expression while preserving COL II. The PCEC/TAmP hydrogel enabled sustained release and improved cartilage penetration of miR-302c-3p, enhancing its therapeutic efficacy in OA mice.

Conclusion: miR-302c-3p-loaded PCEC/TAmP hydrogel may be a promising intra-articular strategy for targeted OA treatment.

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Cite

BibTeXRIS
BibTeX
@article{zhao2026mir302c3pencapsulated,
  title = {{MiR-302c-3p-Encapsulated Cationic TAmP PCEC Hydrogels for Targeted ADAMTS5 Suppression and Osteoarthritis Treatment}},
  author = {Yuzhou Zhao and Yongheng Ye and Tianyu Zhao and Zeyang Yao and Yong Liu and Dianbo Long and Jianhua Liu and Xiaoyi Zhao and Peiheng He},
  journal = {International Journal of Nanomedicine},
  year = {2026},
  month = oct,
  doi = {10.2147/ijn.s631283},
  url = {https://doi.org/10.2147/ijn.s631283},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - MiR-302c-3p-Encapsulated Cationic TAmP PCEC Hydrogels for Targeted ADAMTS5 Suppression and Osteoarthritis Treatment
AU  - Yuzhou Zhao
AU  - Yongheng Ye
AU  - Tianyu Zhao
AU  - Zeyang Yao
AU  - Yong Liu
AU  - Dianbo Long
AU  - Jianhua Liu
AU  - Xiaoyi Zhao
AU  - Peiheng He
PY  - 2026
DA  - 2026/10/26
JO  - International Journal of Nanomedicine
DO  - 10.2147/ijn.s631283
UR  - https://doi.org/10.2147/ijn.s631283
AB  - Introduction: Osteoarthritis (OA) remains a degenerative joint disorder with limited treatment options.  Methods: We examined miR-302c-3p expression in human OA cartilage and primary chondrocytes, validated ADAMTS5 as a direct target, and developed a PCEC/TAmP hydrogel for intra-articular delivery in a DMM mouse model.  Results: miR-302c-3p was downregulated in OA cartilage and attenuated IL-1β-induced chondrocyte catabolism by reducing ADAMTS5, MMP1, and MMP13 expression while preserving COL II. The PCEC/TAmP hydrogel enabled sustained release and improved cartilage penetration of miR-302c-3p, enhancing its therapeutic efficacy in OA mice.  Conclusion: miR-302c-3p-loaded PCEC/TAmP hydrogel may be a promising intra-articular strategy for targeted OA treatment.
SN  - 1176-9114
SN  - 1178-2013
ER  -