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Peer-reviewedCC BY-NC-ND 4.0Scientific Reports

Admission to a referral centre and one-year mortality among patients with infective endocarditis in a French multicentre cohort

  • Benjamin Lefèvre
  • Marie-Line Erpelding
  • Yoann Dominique
  • Bruno Hoen
  • François Alla
  • Xavier Duval
  • François Vandenesch
  • Vincent Le Moing
  • Pierre Tattevin
  • Catherine Chirouze
  • Christine Selton-Suty
  • Nelly Agrinier
Open at sourcePDFDOICite

Abstract

Infective endocarditis (IE) is a potentially fatal condition. Early consultation with the nearest IE team and timely referral in the event of complications are recommended. This study investigated the association between receiving care in a reference centre and one-year mortality among patients with IE. Patients with definite IE enrolled in the EI 2008 cohort, a prospective population based-study, were categorised into three groups: 1) initially admitted to a reference centre (R); 2) initially admitted to a nonreference centre and subsequently referred to a reference centre (NR-R); and 3) exclusively managed in a nonreference centre (NR). Cox models were used for analysis. In our sample, 496 patients (279 R, 160 NR-R, and 57 NR) were included. Patients in the R and NR-R groups were younger and had a higher rate of indications for cardiac surgery. Overall, 142 patients (28.6%) died during follow-up. Care in a reference centre at any point was not associated with one-year mortality (crude-HR [95% CI]: 0.87 [0.57–1.33], p=0.518; adjusted-HR 0.98 [0.62–1.56], p=0.933). Further adjustment for valve surgery did not affect these results (adjusted HR 0.95 [0.59–1.53], p=0.831). Management at a reference centre was not associated with one-year mortality.

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Cite

BibTeXRIS
BibTeX
@article{lefevre2026admission,
  title = {{Admission to a referral centre and one-year mortality among patients with infective endocarditis in a French multicentre cohort}},
  author = {Benjamin Lefèvre and Marie-Line Erpelding and Yoann Dominique and Bruno Hoen and François Alla and Xavier Duval and François Vandenesch and Vincent Le Moing and Pierre Tattevin and Catherine Chirouze and Christine Selton-Suty and Nelly Agrinier},
  journal = {Scientific Reports},
  year = {2026},
  month = aug,
  doi = {10.1038/s41598-026-64383-1},
  url = {https://hal.science/hal-05756911v1},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Admission to a referral centre and one-year mortality among patients with infective endocarditis in a French multicentre cohort
AU  - Benjamin Lefèvre
AU  - Marie-Line Erpelding
AU  - Yoann Dominique
AU  - Bruno Hoen
AU  - François Alla
AU  - Xavier Duval
AU  - François Vandenesch
AU  - Vincent Le Moing
AU  - Pierre Tattevin
AU  - Catherine Chirouze
AU  - Christine Selton-Suty
AU  - Nelly Agrinier
PY  - 2026
DA  - 2026/08/27
JO  - Scientific Reports
DO  - 10.1038/s41598-026-64383-1
UR  - https://hal.science/hal-05756911v1
AB  - Infective endocarditis (IE) is a potentially fatal condition. Early consultation with the nearest IE team and timely referral in the event of complications are recommended. This study investigated the association between receiving care in a reference centre and one-year mortality among patients with IE. Patients with definite IE enrolled in the EI 2008 cohort, a prospective population based-study, were categorised into three groups: 1) initially admitted to a reference centre (R); 2) initially admitted to a nonreference centre and subsequently referred to a reference centre (NR-R); and 3) exclusively managed in a nonreference centre (NR). Cox models were used for analysis. In our sample, 496 patients (279 R, 160 NR-R, and 57 NR) were included. Patients in the R and NR-R groups were younger and had a higher rate of indications for cardiac surgery. Overall, 142 patients (28.6%) died during follow-up. Care in a reference centre at any point was not associated with one-year mortality (crude-HR [95% CI]: 0.87 [0.57–1.33], p=0.518; adjusted-HR 0.98 [0.62–1.56], p=0.933). Further adjustment for valve surgery did not affect these results (adjusted HR 0.95 [0.59–1.53], p=0.831). Management at a reference centre was not associated with one-year mortality.
SN  - 2045-2322
ER  -