Multimodal Fluorescent MOF@BODIPY Platform: Bridging Sensing and Mechanistic Insight
4 affiliations
- 1Department of Analytical Chemistry University of Valencia Burjassot Valencia Spain
- 2Department of Chemistry and Pharmacy Chair of Physical Chemistry I Friedrich Alexander University of Erlangen‐Nürnberg Erlangen Germany
- 3Instituto Interuniversitario de Reconocimiento Molecular y Desarrollo Tecnológico (IDM) Universitat De València – Universitat Politècnica de València and Department of Organic Chemistry University of Valencia Burjassot Valencia Spain
- 4Institute of Molecular Science University of Valencia Paterna Valencia Spain
Abstract
Hybrid metal–organic frameworks (MOFs) that integrate organic chromophores constitute powerful platforms for optical sensing by combining structural order with tunable photophysics. Incorporating photoresponsive chromophores into MOFs enables sensitive probing of guest–framework interactions through well‐defined luminescent signatures. Herein, we present a hybrid luminescent platform, based on a UiO‐66‐NH2 MOF covalently functionalized with BODIPY dyes (MOF@BODIPY), designed for advanced optical sensing. The material integrates two independent excitation channels: selective activation of the MOF scaffold and the BODIPY chromophore at 400 and 500 nm, respectively. This dual‐channel architecture enables simultaneous quantitative detection and mechanistic insight, bridging sensing performance with fundamental photophysics. Under BODIPY excitation, MOF@BODIPY exhibits strong fluorescence quenching response toward Fe3+ ions, achieving a limit of detection as low as 0.07 µM. Complementary excitation of the MOF scaffold reveals fluorescence enhancement, providing mechanistic evidence of coordination‐driven suppression of nonradiative pathways. Time‐resolved fluorescence spectroscopy confirms static quenching at the dye level and dynamic modulation within the MOF framework, highlighting synergistic interactions between both components. The hybrid's low‐cost synthesis, high sensitivity, and dual optical functionality positions MOF@BODIPY as a versatile proof‐of‐concept for multimodal sensing platforms and highlights its potential for next‐generation optical sensors in environmental applications.
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BibTeX
@article{cortesvillena2026multimodal,
title = {{Multimodal Fluorescent MOF@BODIPY Platform: Bridging Sensing and Mechanistic Insight}},
author = {Alejandro Cortés‐Villena and Paula Rodrigo‐Martínez and José A. Sáez and Pablo Gaviña and Emilio Pardo and Raquel E. Galian and Sergio Armenta and Héctor Martínez‐Pérez‐Cejuela and José Manuel Herrero‐Martínez},
journal = {Chemistry (Weinheim an Der Bergstrasse, Germany)},
year = {2026},
month = jul,
doi = {10.1002/chem.71436},
url = {https://doi.org/10.1002/chem.71436},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Multimodal Fluorescent MOF@BODIPY Platform: Bridging Sensing and Mechanistic Insight
AU - Alejandro Cortés‐Villena
AU - Paula Rodrigo‐Martínez
AU - José A. Sáez
AU - Pablo Gaviña
AU - Emilio Pardo
AU - Raquel E. Galian
AU - Sergio Armenta
AU - Héctor Martínez‐Pérez‐Cejuela
AU - José Manuel Herrero‐Martínez
PY - 2026
DA - 2026/07/20
JO - Chemistry (Weinheim an Der Bergstrasse, Germany)
DO - 10.1002/chem.71436
UR - https://doi.org/10.1002/chem.71436
AB - Hybrid metal–organic frameworks (MOFs) that integrate organic chromophores constitute powerful platforms for optical sensing by combining structural order with tunable photophysics. Incorporating photoresponsive chromophores into MOFs enables sensitive probing of guest–framework interactions through well‐defined luminescent signatures. Herein, we present a hybrid luminescent platform, based on a UiO‐66‐NH2 MOF covalently functionalized with BODIPY dyes (MOF@BODIPY), designed for advanced optical sensing. The material integrates two independent excitation channels: selective activation of the MOF scaffold and the BODIPY chromophore at 400 and 500 nm, respectively. This dual‐channel architecture enables simultaneous quantitative detection and mechanistic insight, bridging sensing performance with fundamental photophysics. Under BODIPY excitation, MOF@BODIPY exhibits strong fluorescence quenching response toward Fe3+ ions, achieving a limit of detection as low as 0.07 µM. Complementary excitation of the MOF scaffold reveals fluorescence enhancement, providing mechanistic evidence of coordination‐driven suppression of nonradiative pathways. Time‐resolved fluorescence spectroscopy confirms static quenching at the dye level and dynamic modulation within the MOF framework, highlighting synergistic interactions between both components. The hybrid's low‐cost synthesis, high sensitivity, and dual optical functionality positions MOF@BODIPY as a versatile proof‐of‐concept for multimodal sensing platforms and highlights its potential for next‐generation optical sensors in environmental applications.
SN - 0947-6539
SN - 1521-3765
ER -