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Peer-reviewedCC BY-NC-NDClinical neurophysiology practice

Epileptic hub in MRI-negative focal cortical dysplasia using advanced dynamic statistical parametric mapping and magnetoencephalography.

  • Yasuyoshi Hiramatsu1
  • Midori Nakajima1
  • Fumiya Takeuchi2
  • Masashi Narugami1
  • Satoshi Yamada1
  • Sachiko Nakakubo1
  • Takeru Goto1
  • Shuhei Kimura1
  • Yuki Ueda1
  • Noriyuki Fujima3
  • Kenji Hirata3
  • Yuuki Ishida4
8 more authors
  • Yoko Aburakawa5
  • Keiya Iijima6
  • Masaki Iwasaki6
  • Rei Enatsu7
  • Nobuhiro Mikuni7
  • Hideaki Shiraishi8
  • Atsushi Manabe1
  • Kiyoshi Egawa1
8 affiliations
  1. 1Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  2. 2Department of Clinical Engineering, Japan Healthcare University, Sapporo, Japan.
  3. 3Department of Diagnostic Imaging, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
  4. 4Department of Neurology, Nakamura Memorial Hospital, Hokkaido, Japan.
  5. 5Department of Neurosurgery, Nakamura Memorial Hospital, Hokkaido, Japan.
  6. 6Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
  7. 7Department of Neurosurgery, Sapporo Medical University, School of Medicine, Sapporo, Japan.
  8. 8Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
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Abstract

Objective

Localization of epileptogenic MRI-negative focal cortical dysplasia at the bottom of the sulcus (FCDB) is challenging. This study evaluated the utility of advanced dynamic statistical parametric mapping (AdSPM), a magnetoencephalography (MEG)-based source analysis method, for detecting epileptic MRI-negative FCDB.Methods

We retrospectively analyzed MEG data using AdSPM in four patients with pathologically confirmed MRI-negative FCDB, whose seizure onset zones were identified by intracranial video-EEG (IVEEG). The most active area identified by the AdSPM was designated as the AdSPM spike source. We compared the spatial concordance of the AdSPM spike source, single moving dipole (SMD) findings, and ¹⁸F-FDG PET/MRI findings with seizure onset and resection areas. An additional MRI-negative patient without seizures during IVEEG monitoring was analyzed separately for concordance with the resection area.Results

The AdSPM spike source localized to the seizure onset zone and was included in the resection area in all four patients with an identified seizure onset zone. SMD findings were mislocalized relative to the seizure onset zone and resection area. PET/MRI was concordant with the seizure onset zone in one of three evaluable patients and with the resection area in three of four patients. In the patient without seizures during IVEEG, AdSPM and PET/MRI were concordant with the resection area; however, the SMD findings were mislocalized.Conclusions

AdSPM noninvasively and neurophysiologically localizes epileptic MRI-negative FCDB and may provide useful information for presurgical evaluations.Significance

This is the first diagnostic application of AdSPM for MRI-negative FCDB.

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Cite

BibTeXRIS
BibTeX
@article{hiramatsu2026epileptic,
  title = {{Epileptic hub in MRI-negative focal cortical dysplasia using advanced dynamic statistical parametric mapping and magnetoencephalography.}},
  author = {Yasuyoshi Hiramatsu and Midori Nakajima and Fumiya Takeuchi and Masashi Narugami and Satoshi Yamada and Sachiko Nakakubo and Takeru Goto and Shuhei Kimura and Yuki Ueda and Noriyuki Fujima and Kenji Hirata and Yuuki Ishida and Yoko Aburakawa and Keiya Iijima and Masaki Iwasaki and Rei Enatsu and Nobuhiro Mikuni and Hideaki Shiraishi and Atsushi Manabe and Kiyoshi Egawa},
  journal = {Clinical neurophysiology practice},
  year = {2026},
  month = oct,
  doi = {10.1016/j.cnp.2026.09.007},
  url = {https://europepmc.org/article/MED/42910304},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Epileptic hub in MRI-negative focal cortical dysplasia using advanced dynamic statistical parametric mapping and magnetoencephalography.
AU  - Yasuyoshi Hiramatsu
AU  - Midori Nakajima
AU  - Fumiya Takeuchi
AU  - Masashi Narugami
AU  - Satoshi Yamada
AU  - Sachiko Nakakubo
AU  - Takeru Goto
AU  - Shuhei Kimura
AU  - Yuki Ueda
AU  - Noriyuki Fujima
AU  - Kenji Hirata
AU  - Yuuki Ishida
AU  - Yoko Aburakawa
AU  - Keiya Iijima
AU  - Masaki Iwasaki
AU  - Rei Enatsu
AU  - Nobuhiro Mikuni
AU  - Hideaki Shiraishi
AU  - Atsushi Manabe
AU  - Kiyoshi Egawa
PY  - 2026
DA  - 2026/10/01
JO  - Clinical neurophysiology practice
DO  - 10.1016/j.cnp.2026.09.007
UR  - https://europepmc.org/article/MED/42910304
AB  - Objective  Localization of epileptogenic MRI-negative focal cortical dysplasia at the bottom of the sulcus (FCDB) is challenging. This study evaluated the utility of advanced dynamic statistical parametric mapping (AdSPM), a magnetoencephalography (MEG)-based source analysis method, for detecting epileptic MRI-negative FCDB.Methods  We retrospectively analyzed MEG data using AdSPM in four patients with pathologically confirmed MRI-negative FCDB, whose seizure onset zones were identified by intracranial video-EEG (IVEEG). The most active area identified by the AdSPM was designated as the AdSPM spike source. We compared the spatial concordance of the AdSPM spike source, single moving dipole (SMD) findings, and ¹⁸F-FDG PET/MRI findings with seizure onset and resection areas. An additional MRI-negative patient without seizures during IVEEG monitoring was analyzed separately for concordance with the resection area.Results  The AdSPM spike source localized to the seizure onset zone and was included in the resection area in all four patients with an identified seizure onset zone. SMD findings were mislocalized relative to the seizure onset zone and resection area. PET/MRI was concordant with the seizure onset zone in one of three evaluable patients and with the resection area in three of four patients. In the patient without seizures during IVEEG, AdSPM and PET/MRI were concordant with the resection area; however, the SMD findings were mislocalized.Conclusions  AdSPM noninvasively and neurophysiologically localizes epileptic MRI-negative FCDB and may provide useful information for presurgical evaluations.Significance  This is the first diagnostic application of AdSPM for MRI-negative FCDB.
SN  - 2467-981X
ER  -