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Peer-reviewedCC BYVeterinary sciences

Pathogenicity and Comparative Genomics Analysis: Pasteurella multocida Serogroups A and F Isolated from Domestic Rabbits in China.

  • Qiaoya Zhao1,2
  • Cunxia Liu1,2
  • Xiuli Ma1,2
  • Feng Hu1,2
  • Junfeng Lv1,2
  • Tong Zhu1,2
  • Yajian Gao3
  • Changhao Liu4
  • Bing Huang1,2
  • Yifei Jiang1,2
4 affiliations
  1. 1Poultry Institute, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
  2. 2Shandong Provincial Key Laboratory of Livestock and Poultry Breeding, Jinan 250100, China.
  3. 3College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010011, China.
  4. 4Qilu Animal Health Products Co., Ltd., Jinan 250100, China.
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Abstract

Pasteurella multocida is a zoonotic pathogen that causes severe respiratory infections in domestic rabbits. Serogroup F strains have been increasingly reported but remain poorly characterized. Two strains, PS-JQ08 (serogroup A) and PS-JQ09 (serogroup F), were isolated from deceased rabbits in China. Pathogenicity was assessed in mouse and rabbit models, and whole-genome sequencing was performed for comparative genomic analysis. Both strains were highly pathogenic but induced distinct pathological profiles: PS-JQ08 caused hepatocellular vacuolar degeneration, whereas PS-JQ09 induced hemorrhage and edema. Genomic analysis revealed that both strains harbored core virulence genes involved in adhesion, iron acquisition, and antiphagocytosis; however, the serogroup F strain harbored unique iron transport genes and arsenic resistance systems. Phylogenetic analysis revealed that PS-JQ08 clustered with avian serogroup A strains, whereas PS-JQ09 clustered with porcine- and rabbit-derived serogroup F strains. These findings provide clues for exploring the genetic mechanism underlying pathogenic differentiation of Pasteurella multocida between serogroups A and F, and provide valuable genomic information to support vaccine development and disease control in rabbits.

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Cite

BibTeXRIS
BibTeX
@article{zhao2026pathogenicity,
  title = {{Pathogenicity and Comparative Genomics Analysis: Pasteurella multocida Serogroups A and F Isolated from Domestic Rabbits in China.}},
  author = {Qiaoya Zhao and Cunxia Liu and Xiuli Ma and Feng Hu and Junfeng Lv and Tong Zhu and Yajian Gao and Changhao Liu and Bing Huang and Yifei Jiang},
  journal = {Veterinary sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/vetsci13101058},
  url = {https://europepmc.org/article/MED/42944153},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Pathogenicity and Comparative Genomics Analysis: Pasteurella multocida Serogroups A and F Isolated from Domestic Rabbits in China.
AU  - Qiaoya Zhao
AU  - Cunxia Liu
AU  - Xiuli Ma
AU  - Feng Hu
AU  - Junfeng Lv
AU  - Tong Zhu
AU  - Yajian Gao
AU  - Changhao Liu
AU  - Bing Huang
AU  - Yifei Jiang
PY  - 2026
DA  - 2026/10/08
JO  - Veterinary sciences
DO  - 10.3390/vetsci13101058
UR  - https://europepmc.org/article/MED/42944153
AB  - Pasteurella multocida is a zoonotic pathogen that causes severe respiratory infections in domestic rabbits. Serogroup F strains have been increasingly reported but remain poorly characterized. Two strains, PS-JQ08 (serogroup A) and PS-JQ09 (serogroup F), were isolated from deceased rabbits in China. Pathogenicity was assessed in mouse and rabbit models, and whole-genome sequencing was performed for comparative genomic analysis. Both strains were highly pathogenic but induced distinct pathological profiles: PS-JQ08 caused hepatocellular vacuolar degeneration, whereas PS-JQ09 induced hemorrhage and edema. Genomic analysis revealed that both strains harbored core virulence genes involved in adhesion, iron acquisition, and antiphagocytosis; however, the serogroup F strain harbored unique iron transport genes and arsenic resistance systems. Phylogenetic analysis revealed that PS-JQ08 clustered with avian serogroup A strains, whereas PS-JQ09 clustered with porcine- and rabbit-derived serogroup F strains. These findings provide clues for exploring the genetic mechanism underlying pathogenic differentiation of Pasteurella multocida between serogroups A and F, and provide valuable genomic information to support vaccine development and disease control in rabbits.
SN  - 2306-7381
ER  -