Crosstalk between ubiquitination and other post-translational modifications in cardiovascular diseases.
- 1National Key Clinical Specialty, Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
- 2Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
- 3Department of Cardiology, Tinghu People's Hospital of Yancheng City, Yancheng 224000, China.
Abstract
Cardiovascular diseases (CVDs) remain a major cause of morbidity and mortality worldwide. Post-translational modifications (PTMs) are increasingly recognized as important regulators of cardiovascular pathophysiology, but how different PTMs interact in CVDs is still incompletely understood. This review focuses on the crosstalk between ubiquitination and other PTMs, including phosphorylation, SUMOylation, acetylation, methylation, O-GlcNAcylation, neddylation, and ADP-ribosylation/PARylation. We summarize representative cardiovascular mechanisms in which these modifications act competitively, cooperatively, or sequentially to influence protein stability, signaling, and function. We also discuss current limitations in establishing PTM interactions and highlight areas that require further investigation. A clearer understanding of these regulatory relationships may help identify disease-relevant PTM pathways and potential therapeutic targets in CVDs.
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BibTeX
@article{yan2026crosstalk,
title = {{Crosstalk between ubiquitination and other post-translational modifications in cardiovascular diseases.}},
author = {Yi Yan and Zhiqiang Li and Tingting Xiao},
journal = {IScience},
year = {2026},
month = sep,
doi = {10.1016/j.isci.2026.117606},
url = {https://europepmc.org/article/MED/42835060},
note = {CC BY},
}
RIS
TY - JOUR
TI - Crosstalk between ubiquitination and other post-translational modifications in cardiovascular diseases.
AU - Yi Yan
AU - Zhiqiang Li
AU - Tingting Xiao
PY - 2026
DA - 2026/09/24
JO - IScience
DO - 10.1016/j.isci.2026.117606
UR - https://europepmc.org/article/MED/42835060
AB - Cardiovascular diseases (CVDs) remain a major cause of morbidity and mortality worldwide. Post-translational modifications (PTMs) are increasingly recognized as important regulators of cardiovascular pathophysiology, but how different PTMs interact in CVDs is still incompletely understood. This review focuses on the crosstalk between ubiquitination and other PTMs, including phosphorylation, SUMOylation, acetylation, methylation, O-GlcNAcylation, neddylation, and ADP-ribosylation/PARylation. We summarize representative cardiovascular mechanisms in which these modifications act competitively, cooperatively, or sequentially to influence protein stability, signaling, and function. We also discuss current limitations in establishing PTM interactions and highlight areas that require further investigation. A clearer understanding of these regulatory relationships may help identify disease-relevant PTM pathways and potential therapeutic targets in CVDs.
SN - 2589-0042
ER -