Prognostic impact of the preoperative Naples prognostic score on overall and progression-free survival in surgically treated oral squamous cell carcinoma: A retrospective cohort study from a Taiwanese medical center.
4 affiliations
- 1School of Dentistry and Graduate Institute of Dental Science, National Defense Medical University, Taipei, Taiwan.
- 2Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan.
- 3Institute of Biology and Anatomy, College of Medicine, National Defense Medical University, Taipei, Taiwan.
- 4Graduate Institute of Medical Sciences, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Abstract
Background/purpose
Systemic inflammation and nutritional status are key determinants of cancer progression and survival. The Naples prognostic score (NPS), integrating nutritional and inflammatory biomarkers, has shown prognostic value in cancers, however its significance in oral squamous cell carcinoma (OSCC) remains unclear. This study evaluated the prognostic value of NPS in patients with OSCC undergoing curative surgery.Materials and methods
This retrospective cohort study included 334 patients with OSCC who underwent surgery at a Taiwanese medical center between 2002 and 2015. Preoperative serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio were used to calculate NPS. Patients were categorized into three groups: Group 0 (score=0), Group 1 (score = 1-2), and Group 2 (score = 3-4). Five-year overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meier methods and log-rank tests. Multivariate Cox proportional hazards regression was performed to identify independent prognostic factors.Results
The 5-year OS and PFS rates were 60.0% and 47.9%, respectively. Higher NPS values were significantly associated with poorer OS and PFS (log-rank P<0.0001). In multivariate analysis, NPS remained an independent prognostic factor for OS. Compared with Group 0, hazard ratios were 2.06 for Group 1 and 2.60 for Group 2 (P=0.038). The prognostic significance of NPS persisted after adjustment for clinicopathological variables, including surgical margin status, depth of invasion, and extranodal extension.Conclusion
NPS is an independent prognostic indicator in patients with OSCC undergoing surgery. Incorporating NPS into preoperative assessment may improve risk stratification and support treatment planning.
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BibTeX
@article{hsueh2026prognostic,
title = {{Prognostic impact of the preoperative Naples prognostic score on overall and progression-free survival in surgically treated oral squamous cell carcinoma: A retrospective cohort study from a Taiwanese medical center.}},
author = {Pei-Lun Hsueh and Yu-Hsuan Li and Cheng-Yu Yang and Gu-Jiun Lin and Yuan-Wu Chen and Wei-Chin Chang},
journal = {Journal of dental sciences},
year = {2026},
month = oct,
doi = {10.1016/j.jds.2025.07.3470},
url = {https://europepmc.org/article/MED/42923665},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Prognostic impact of the preoperative Naples prognostic score on overall and progression-free survival in surgically treated oral squamous cell carcinoma: A retrospective cohort study from a Taiwanese medical center.
AU - Pei-Lun Hsueh
AU - Yu-Hsuan Li
AU - Cheng-Yu Yang
AU - Gu-Jiun Lin
AU - Yuan-Wu Chen
AU - Wei-Chin Chang
PY - 2026
DA - 2026/10/01
JO - Journal of dental sciences
DO - 10.1016/j.jds.2025.07.3470
UR - https://europepmc.org/article/MED/42923665
AB - Background/purpose Systemic inflammation and nutritional status are key determinants of cancer progression and survival. The Naples prognostic score (NPS), integrating nutritional and inflammatory biomarkers, has shown prognostic value in cancers, however its significance in oral squamous cell carcinoma (OSCC) remains unclear. This study evaluated the prognostic value of NPS in patients with OSCC undergoing curative surgery.Materials and methods This retrospective cohort study included 334 patients with OSCC who underwent surgery at a Taiwanese medical center between 2002 and 2015. Preoperative serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio were used to calculate NPS. Patients were categorized into three groups: Group 0 (score=0), Group 1 (score = 1-2), and Group 2 (score = 3-4). Five-year overall survival (OS) and progression-free survival (PFS) were analyzed using Kaplan-Meier methods and log-rank tests. Multivariate Cox proportional hazards regression was performed to identify independent prognostic factors.Results The 5-year OS and PFS rates were 60.0% and 47.9%, respectively. Higher NPS values were significantly associated with poorer OS and PFS (log-rank P<0.0001). In multivariate analysis, NPS remained an independent prognostic factor for OS. Compared with Group 0, hazard ratios were 2.06 for Group 1 and 2.60 for Group 2 (P=0.038). The prognostic significance of NPS persisted after adjustment for clinicopathological variables, including surgical margin status, depth of invasion, and extranodal extension.Conclusion NPS is an independent prognostic indicator in patients with OSCC undergoing surgery. Incorporating NPS into preoperative assessment may improve risk stratification and support treatment planning.
SN - 1991-7902
SN - 2213-8862
ER -