Skip to content
DraconiticResearch
Search Sources API
194,164 studies31 sourcesUpdated 28 min ago
Peer-reviewedCC BY 4.0Frontiers in Neuroscience

Microglia in the neurogenic niche: emerging roles of immunometabolism

  • Danping Liu1,2,3,4
  • Yunjun Li1,3,4
  • Yan Liu1,3,4
4 affiliations
  1. 1Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine
  2. 2Wuhan Hospital of Traditional Chinese Medicine
  3. 3Hubei University of Chinese Medicine
  4. 4Hubei Key Laboratory of Theory and Application Research of Liver and Kidney in Traditional Chinese Medicine
Open at sourcePDFDOICite

Abstract

Adult neurogenesis is dynamically regulated by the neurogenic niche, yet the mechanisms governing its remodeling are not fully elucidated. Current research has increasingly extended beyond the intrinsic properties of neural stem cells to consider the broader microenvironment in which neurogenesis occurs, with microglia emerging as important regulators of the neurogenic niche. Drawing upon pathological contexts such as depression and aging, this review characterizes the hallmarks of neurogenic niche dysregulation and synthesizes the mechanisms by which microglia modulate neurogenic efficiency. Particular emphasis is placed on the role of immunometabolism in shaping microglial functional states and subsequent niche remodeling. We propose that microglial immunometabolic states may serve as an important interface through which pathological perturbations within the brain are linked to remodeling of the neurogenic niche, providing a conceptual framework for understanding neurogenic decline across distinct pathological contexts.

Related

  1. Macrophage immunometabolism in osteoporosis: an emerging regulatory axis linking metabolic–polarization coupling to therapeutic targets
    Lian Weng, Qianli Yuan, Taizhou Mo +3
    Frontiers in immunologyPeer-reviewedCC BYFull textImmunologyEurope PMC
  2. Functional niche attributes shape species interaction roles in ecological networks
    G. Albert, A. Davrinche, H. Bruelheide +16
    bioRxivPreprintCC BY-NC-NDFull textEcologybioRxiv
  3. TLR Signaling Beyond Immunity: Emerging Roles in Cell Migration, Metabolism, Development, and Host-Microbiome Crosstalk.
    Li Liu, Herman P Spaink
    BiologyPeer-reviewedCC BYFull textImmunologyEurope PMC
  4. Emerging roles of RIF1 in mitosis
    Suparba Roy, Benjamin Brisebois, Jean-Yves Masson +1
    Nucleic Acids ResearchPeer-reviewedCC BY-NC 4.0Full textCell biologyCrossref
  5. Recent Advances in Protein Tyrosine Sulfation and Its Emerging Roles in Human Diseases
    Ning Liu, Xiaowen Chen, Hailong Zhao +1
    CellsPeer-reviewedCC BY 4.0Cell biologyCrossref

Cite

BibTeXRIS
BibTeX
@article{liu2026microglia,
  title = {{Microglia in the neurogenic niche: emerging roles of immunometabolism}},
  author = {Danping Liu and Yunjun Li and Yan Liu},
  journal = {Frontiers in Neuroscience},
  year = {2026},
  month = oct,
  doi = {10.3389/fnins.2026.2007175},
  url = {https://www.frontiersin.org/articles/10.3389/fnins.2026.2007175/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Microglia in the neurogenic niche: emerging roles of immunometabolism
AU  - Danping Liu
AU  - Yunjun Li
AU  - Yan Liu
PY  - 2026
DA  - 2026/10/22
JO  - Frontiers in Neuroscience
DO  - 10.3389/fnins.2026.2007175
UR  - https://www.frontiersin.org/articles/10.3389/fnins.2026.2007175/full
AB  - Adult neurogenesis is dynamically regulated by the neurogenic niche, yet the mechanisms governing its remodeling are not fully elucidated. Current research has increasingly extended beyond the intrinsic properties of neural stem cells to consider the broader microenvironment in which neurogenesis occurs, with microglia emerging as important regulators of the neurogenic niche. Drawing upon pathological contexts such as depression and aging, this review characterizes the hallmarks of neurogenic niche dysregulation and synthesizes the mechanisms by which microglia modulate neurogenic efficiency. Particular emphasis is placed on the role of immunometabolism in shaping microglial functional states and subsequent niche remodeling. We propose that microglial immunometabolic states may serve as an important interface through which pathological perturbations within the brain are linked to remodeling of the neurogenic niche, providing a conceptual framework for understanding neurogenic decline across distinct pathological contexts.
SN  - 1662-453X
ER  -