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Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Incremental Diagnostic Yield of Fetal MRI After Targeted Neurosonography in Fetuses with Agenesis of the Corpus Callosum: A Retrospective Cohort Study

  • Serdar Aykut1
  • İsmail Cüneyt Evrüke2
  • Süleyman Cansun Demir2
  • Aslıhan Kurt3
  • Ahmet Zeki Nessar4
  • Ayşe Büşra Önder5
5 affiliations
  1. 1Division of Perinatology, Department of Obstetrics and Gynecology, Mardin Training and Research Hospital, Mardin 47100, Türkiye
  2. 2Division of Perinatology, Department of Obstetrics and Gynecology, Çukurova University Faculty of Medicine, Adana 01330, Türkiye
  3. 3Division of Perinatology, University of Health Sciences, Gaziantep City Hospital, Gaziantep 27060, Türkiye
  4. 4Division of Perinatology, Department of Obstetrics and Gynecology, Osmaniye State Hospital, Osmaniye 80000, Türkiye
  5. 5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mardin Training and Research Hospital, Mardin 47100, Türkiye
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Abstract

Background/Objectives: This study aimed to assess additional findings reported on fetal magnetic resonance imaging (MRI) after targeted neurosonography in fetuses with agenesis of the corpus callosum (ACC). Methods: This retrospective cohort included 129 singleton pregnancies with complete or partial ACC evaluated at a tertiary referral center between January 2020 and January 2023. All underwent fetal MRI within 7 days of neurosonography. Incremental findings were abnormalities not identified on the preceding examination. Final isolated or non-isolated classification incorporated both modalities. Results: MRI reported at least one incremental intracranial or craniofacial finding in 42/129 fetuses (32.6%). The most frequent findings were cerebellar hypoplasia (15/129, 11.6%), vermian agenesis (11/129, 8.5%), and arachnoid cysts (9/129, 7.0%). Final classification identified 71 isolated and 58 non-isolated cases. Among 77 tested fetuses, 15 had aneuploidy; the frequency was higher in non-isolated cases (14/37 versus 1/40; p < 0.001). Conclusions: MRI provided additional anatomical information after neurosonography in approximately one-third of this referral cohort. These findings support assessment beyond confirmation of ACC, but do not establish diagnostic accuracy, improved parental decisions, or long-term prognostic benefit.

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Cite

BibTeXRIS
BibTeX
@article{aykut2026incremental,
  title = {{Incremental Diagnostic Yield of Fetal MRI After Targeted Neurosonography in Fetuses with Agenesis of the Corpus Callosum: A Retrospective Cohort Study}},
  author = {Serdar Aykut and İsmail Cüneyt Evrüke and Süleyman Cansun Demir and Aslıhan Kurt and Ahmet Zeki Nessar and Ayşe Büşra Önder},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = nov,
  doi = {10.3390/jcm15218502},
  url = {https://www.mdpi.com/2077-0383/15/21/8502},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Incremental Diagnostic Yield of Fetal MRI After Targeted Neurosonography in Fetuses with Agenesis of the Corpus Callosum: A Retrospective Cohort Study
AU  - Serdar Aykut
AU  - İsmail Cüneyt Evrüke
AU  - Süleyman Cansun Demir
AU  - Aslıhan Kurt
AU  - Ahmet Zeki Nessar
AU  - Ayşe Büşra Önder
PY  - 2026
DA  - 2026/11/02
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15218502
UR  - https://www.mdpi.com/2077-0383/15/21/8502
AB  - Background/Objectives: This study aimed to assess additional findings reported on fetal magnetic resonance imaging (MRI) after targeted neurosonography in fetuses with agenesis of the corpus callosum (ACC). Methods: This retrospective cohort included 129 singleton pregnancies with complete or partial ACC evaluated at a tertiary referral center between January 2020 and January 2023. All underwent fetal MRI within 7 days of neurosonography. Incremental findings were abnormalities not identified on the preceding examination. Final isolated or non-isolated classification incorporated both modalities. Results: MRI reported at least one incremental intracranial or craniofacial finding in 42/129 fetuses (32.6%). The most frequent findings were cerebellar hypoplasia (15/129, 11.6%), vermian agenesis (11/129, 8.5%), and arachnoid cysts (9/129, 7.0%). Final classification identified 71 isolated and 58 non-isolated cases. Among 77 tested fetuses, 15 had aneuploidy; the frequency was higher in non-isolated cases (14/37 versus 1/40; p < 0.001). Conclusions: MRI provided additional anatomical information after neurosonography in approximately one-third of this referral cohort. These findings support assessment beyond confirmation of ACC, but do not establish diagnostic accuracy, improved parental decisions, or long-term prognostic benefit.
SN  - 2077-0383
ER  -