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Peer-reviewedCC BY 4.0Cells

Proposed Interactions and Crosstalk Among Biological Aging Biomarkers (Telomere Length, Telomerase, Sirtuins, mtDNA Copy Number and mtDNA Methylation Levels) and Their Potential Role in Colorectal Cancer Risk: A Review

  • Engelinah Dikeledi Macamo1,2
  • Pragalathan Naidoo1,2
  • Sibusiso Senzani1
  • Khethiwe Nomcebo Bhengu1,2,3,4
  • Sayed Shakeel Kader5
  • Zilungile Lynette Mkhize-Kwitshana1,2,6
6 affiliations
  1. 1Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, Nelson R. Mandela Medical School Campus, University of KwaZulu-Natal, Durban 4001, South Africa
  2. 2Division of Research Capacity Development (RCD), South African Medical Research Council (SAMRC), Tygerberg, Cape Town 7505, South Africa
  3. 3Department of Biomedical Sciences, Faculty of Natural Sciences, Mangosuthu University of Technology, Umlazi, Durban 4031, South Africa
  4. 4Internal Medicine, Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg 2017, South Africa
  5. 5Department of Surgery, University of KwaZulu Natal, Durban 4001, South Africa
  6. 6Biomedical Sciences Department, School of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Florida Campus, Johannesburg 1710, South Africa
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Abstract

There is a rapid increase in early onset CRC worldwide. This incidence is profoundly influenced by biological aging in the colon, yet the underlying mechanisms remain incompletely defined. This review critically evaluates evidence supporting proposed interactions among telomere dynamics, sirtuins, and mitochondrial biomarkers during colon aging and as CRC risk predictors, while highlighting areas where mechanistic validation remains limited. This insight paves the way for novel early-detection biomarkers, personalized preventive approaches, and treatments designed to directly interfere with aging mechanisms and CRC risk.

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Cite

BibTeXRIS
BibTeX
@article{macamo2026proposed,
  title = {{Proposed Interactions and Crosstalk Among Biological Aging Biomarkers (Telomere Length, Telomerase, Sirtuins, mtDNA Copy Number and mtDNA Methylation Levels) and Their Potential Role in Colorectal Cancer Risk: A Review}},
  author = {Engelinah Dikeledi Macamo and Pragalathan Naidoo and Sibusiso Senzani and Khethiwe Nomcebo Bhengu and Sayed Shakeel Kader and Zilungile Lynette Mkhize-Kwitshana},
  journal = {Cells},
  year = {2026},
  month = oct,
  doi = {10.3390/cells15211994},
  url = {https://www.mdpi.com/2073-4409/15/21/1994},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Proposed Interactions and Crosstalk Among Biological Aging Biomarkers (Telomere Length, Telomerase, Sirtuins, mtDNA Copy Number and mtDNA Methylation Levels) and Their Potential Role in Colorectal Cancer Risk: A Review
AU  - Engelinah Dikeledi Macamo
AU  - Pragalathan Naidoo
AU  - Sibusiso Senzani
AU  - Khethiwe Nomcebo Bhengu
AU  - Sayed Shakeel Kader
AU  - Zilungile Lynette Mkhize-Kwitshana
PY  - 2026
DA  - 2026/10/31
JO  - Cells
DO  - 10.3390/cells15211994
UR  - https://www.mdpi.com/2073-4409/15/21/1994
AB  - There is a rapid increase in early onset CRC worldwide. This incidence is profoundly influenced by biological aging in the colon, yet the underlying mechanisms remain incompletely defined. This review critically evaluates evidence supporting proposed interactions among telomere dynamics, sirtuins, and mitochondrial biomarkers during colon aging and as CRC risk predictors, while highlighting areas where mechanistic validation remains limited. This insight paves the way for novel early-detection biomarkers, personalized preventive approaches, and treatments designed to directly interfere with aging mechanisms and CRC risk.
SN  - 2073-4409
ER  -