Dispersion-engineered meta-coverslip for multimodal synthetic imaging
Abstract
Multimodal optical imaging provides comprehensive sample characterization but has traditionally been hindered by complex and bulky instrumentation. Here, we propose a dispersion-engineered meta-coverslip to seamlessly integrate bright-field, differential, fluorescence, and holographic imaging modalities within a standard microscope architecture, requiring no hardware modification or realignment. The meta-coverslip utilizes a scalable subwavelength multilayer film to engineer spatio-temporal dispersion for a customized high-dimensional transfer function. As an example, we demonstrate flexible switching among the four imaging modalities by simply tuning the illumination wavelengths. Lastly, we demonstrate that the synthesis of multimodal images can provide spatially registered structural and molecular information for more comprehensive biological analysis. Our approach provides an accessible, scalable, and flexible solution for advanced imaging and is extensible to other multiplexed optical systems in sensing and computing.
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BibTeX
@misc{ma2026dispersionengineered,
title = {{Dispersion-engineered meta-coverslip for multimodal synthetic imaging}},
author = {Yuchen Ma and Danlin Xu and Xinwei Wang and Guangwei Hu and Liangcai Cao},
howpublished = {arXiv},
year = {2026},
month = sep,
doi = {10.48550/arxiv.2609.02335},
eprint = {2609.02335},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2609.02335},
}
RIS
TY - UNPB
TI - Dispersion-engineered meta-coverslip for multimodal synthetic imaging
AU - Yuchen Ma
AU - Danlin Xu
AU - Xinwei Wang
AU - Guangwei Hu
AU - Liangcai Cao
PY - 2026
DA - 2026/09/02
PB - arXiv
DO - 10.48550/arxiv.2609.02335
UR - https://arxiv.org/abs/2609.02335
AB - Multimodal optical imaging provides comprehensive sample characterization but has traditionally been hindered by complex and bulky instrumentation. Here, we propose a dispersion-engineered meta-coverslip to seamlessly integrate bright-field, differential, fluorescence, and holographic imaging modalities within a standard microscope architecture, requiring no hardware modification or realignment. The meta-coverslip utilizes a scalable subwavelength multilayer film to engineer spatio-temporal dispersion for a customized high-dimensional transfer function. As an example, we demonstrate flexible switching among the four imaging modalities by simply tuning the illumination wavelengths. Lastly, we demonstrate that the synthesis of multimodal images can provide spatially registered structural and molecular information for more comprehensive biological analysis. Our approach provides an accessible, scalable, and flexible solution for advanced imaging and is extensible to other multiplexed optical systems in sensing and computing.
ER -