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Peer-reviewedCC BY-NC-NDJournal of the American Heart Association

Impact of Continuous Baseline and Discharge Blood Pressure on Outcomes After Transcatheter Aortic Valve Implantation

  • Thorald Stolte1
  • Jakob Johannes Reichl1
  • Felix Goetzinger1
  • Max Wagener1
  • Ketina Arslani1
  • Anke von Peter1
  • Rahel Berger1
  • Christoph Kaiser1
  • Michael Böhm2
  • Lucas Lauder1
  • Felix Mahfoud1
  • Thomas Nestelberger1
  1. 1University Hospital Basel, University of Basel
  2. 2HOMICAREM (HOMburg Institute for CArdioREnalMetabolic Medicine), Saarland University Hospital, Saarland University
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Abstract

INTRODUCTION: Evidence linking pre- and post-transcatheter aortic valve implantation (TAVI) blood pressure (BP) with cardiovascular outcomes is scarce. This study investigated the associations of pre- and post-TAVI BP and their changes as a continuous variable with cardiovascular outcomes. METHODS: Patients undergoing TAVI at a tertiary university hospital between 2011 and 2025 with office BP available before and after TAVI were included. The primary outcome was a composite of major adverse cardiac events (MACE) at 1 year. Multivariable Cox proportional hazards models incorporating restricted cubic splines for continuous variables were fitted. RESULTS: <0.001 for both), whereas baseline systolic BP showed no significant association. BP values <115 mm Hg or >143 mm Hg were associated with a higher risk of MACE 1 year after TAVI. A decrease in systolic BP of -5 to -25 mm Hg was also associated with a lower risk of MACE compared with no change. CONCLUSIONS: While BP remains generally stable in the year following TAVI, both very low and high systolic BP at discharge were associated with higher 1-year MACE. Furthermore, moderate decreases in systolic BP from baseline to discharge appear to be protective. These findings highlight the potential prognostic value of BP optimization during TAVI follow-up and support the role of BP measurements as a clinically translatable, independently associated with long-term outcomes after TAVI.

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Cite

BibTeXRIS
BibTeX
@article{stolte2026impact,
  title = {{Impact of Continuous Baseline and Discharge Blood Pressure on Outcomes After Transcatheter Aortic Valve Implantation}},
  author = {Thorald Stolte and Jakob Johannes Reichl and Felix Goetzinger and Max Wagener and Ketina Arslani and Anke von Peter and Rahel Berger and Christoph Kaiser and Michael Böhm and Lucas Lauder and Felix Mahfoud and Thomas Nestelberger},
  journal = {Journal of the American Heart Association},
  year = {2026},
  month = oct,
  doi = {10.1161/jaha.126.050999},
  url = {https://www.ahajournals.org/doi/10.1161/JAHA.126.050999},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Impact of Continuous Baseline and Discharge Blood Pressure on Outcomes After Transcatheter Aortic Valve Implantation
AU  - Thorald Stolte
AU  - Jakob Johannes Reichl
AU  - Felix Goetzinger
AU  - Max Wagener
AU  - Ketina Arslani
AU  - Anke von Peter
AU  - Rahel Berger
AU  - Christoph Kaiser
AU  - Michael Böhm
AU  - Lucas Lauder
AU  - Felix Mahfoud
AU  - Thomas Nestelberger
PY  - 2026
DA  - 2026/10/20
JO  - Journal of the American Heart Association
DO  - 10.1161/jaha.126.050999
UR  - https://www.ahajournals.org/doi/10.1161/JAHA.126.050999
AB  - INTRODUCTION: Evidence linking pre- and post-transcatheter aortic valve implantation (TAVI) blood pressure (BP) with cardiovascular outcomes is scarce. This study investigated the associations of pre- and post-TAVI BP and their changes as a continuous variable with cardiovascular outcomes. METHODS: Patients undergoing TAVI at a tertiary university hospital between 2011 and 2025 with office BP available before and after TAVI were included. The primary outcome was a composite of major adverse cardiac events (MACE) at 1 year. Multivariable Cox proportional hazards models incorporating restricted cubic splines for continuous variables were fitted. RESULTS: <0.001 for both), whereas baseline systolic BP showed no significant association. BP values <115 mm Hg or >143 mm Hg were associated with a higher risk of MACE 1 year after TAVI. A decrease in systolic BP of -5 to -25 mm Hg was also associated with a lower risk of MACE compared with no change. CONCLUSIONS: While BP remains generally stable in the year following TAVI, both very low and high systolic BP at discharge were associated with higher 1-year MACE. Furthermore, moderate decreases in systolic BP from baseline to discharge appear to be protective. These findings highlight the potential prognostic value of BP optimization during TAVI follow-up and support the role of BP measurements as a clinically translatable, independently associated with long-term outcomes after TAVI.
SN  - 2047-9980
ER  -