Comparative Evaluation of Renal Resistive Index and Serum Calcium, Phosphorus, and Parathyroid Hormone Levels in Diabetic and Non-Diabetic Kidney Disease
7 affiliations
- 1Internal Medicine, Faculty of Medicine, Minia University
- 2Department of Internal Medicine Faculty of Medicine -Minia University
- 3Internal Medicine Department, Faculty of Medicine, Minia University, Egypt
- 4internal medicine department, faculty of medicine, minia university
- 5internal medicine department/ Clinical Endocrinology unit, Faculty of medicine -Minia university, Eygpt.
- 6Radiology Department, Faculty of Medicine, Minia University, Minia, Egypt
- 7internal medicine department faculty of medicine minia univeristy
Abstract
Background: The Doppler-derived renal resistive index (RRI) reflects intrarenal vascular mechanics and systemic hemodynamics, offering prospective clinical value in nephropathy. Objectives: To investigate how RRI metrics correlate with serum levels of parathyroid hormone (PTH), calcium, and phosphorus across diabetic and non-diabetic chronic kidney disease (CKD) cohorts. Patients and methods: A cross-sectional cohort of 100 adult CKD subjects (50 diabetic kidney disease [DKD], 50 non-diabetic CKD) underwent standardized renal duplex ultrasonography alongside serum biochemical profiling for calcium, phosphate, and intact PTH. Results: In DKD patients, right-sided RRI (RRI-Rt) correlated directly with serum phosphate (r = 0.302, p = 0.033) and PTH (r = 0.479, p = 0.001). In non-diabetic CKD, RRI-Rt displayed an inverse relationship with total calcium (r = -0.662, p < 0.001) alongside robust positive relationships with phosphate (r = 0.787, p < 0.001) and PTH (r = 0.799, p < 0.001). Left-sided RRI (RRI-Lt) mirrored these bilateral associations. In the diabetic population, RRI-Lt was positively correlated with phosphorus (r = 0.354, p = 0.012) and PTH (r = 0.386, p = 0.006), while its correlation with calcium did not reach statistical significance. In the non-diabetic group, RRI-Lt showed a strong significant negative correlation with calcium (r = -0.645, p < 0.001), and strong significant positive correlations with phosphorus (r = 0.782, p < 0.001) and PTH (r = 0.797, p < 0.001). Conclusion: Bilateral RRI values parallel hyperphosphatemia and secondary hyperparathyroidism in both diabetic and non-diabetic renal populations, demonstrating enhanced magnitude in non-diabetic CKD.
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BibTeX
@article{eldin2026comparative,
title = {{Comparative Evaluation of Renal Resistive Index and Serum Calcium, Phosphorus, and Parathyroid Hormone Levels in Diabetic and Non-Diabetic Kidney Disease}},
author = {Hassan Mohi El-Din and Amal Helmy and Maha Kahlawy and Aml Azzam and Shreen Mohamed and Tamer El Zaeem and fatmaa kamel},
journal = {Minia Journal of Medical Research},
year = {2026},
month = oct,
doi = {10.21608/mjmr.2026.536418.2404},
url = {https://doi.org/10.21608/mjmr.2026.536418.2404},
note = {CC BY},
}
RIS
TY - JOUR
TI - Comparative Evaluation of Renal Resistive Index and Serum Calcium, Phosphorus, and Parathyroid Hormone Levels in Diabetic and Non-Diabetic Kidney Disease
AU - Hassan Mohi El-Din
AU - Amal Helmy
AU - Maha Kahlawy
AU - Aml Azzam
AU - Shreen Mohamed
AU - Tamer El Zaeem
AU - fatmaa kamel
PY - 2026
DA - 2026/10/25
JO - Minia Journal of Medical Research
DO - 10.21608/mjmr.2026.536418.2404
UR - https://doi.org/10.21608/mjmr.2026.536418.2404
AB - Background: The Doppler-derived renal resistive index (RRI) reflects intrarenal vascular mechanics and systemic hemodynamics, offering prospective clinical value in nephropathy. Objectives: To investigate how RRI metrics correlate with serum levels of parathyroid hormone (PTH), calcium, and phosphorus across diabetic and non-diabetic chronic kidney disease (CKD) cohorts. Patients and methods: A cross-sectional cohort of 100 adult CKD subjects (50 diabetic kidney disease [DKD], 50 non-diabetic CKD) underwent standardized renal duplex ultrasonography alongside serum biochemical profiling for calcium, phosphate, and intact PTH. Results: In DKD patients, right-sided RRI (RRI-Rt) correlated directly with serum phosphate (r = 0.302, p = 0.033) and PTH (r = 0.479, p = 0.001). In non-diabetic CKD, RRI-Rt displayed an inverse relationship with total calcium (r = -0.662, p < 0.001) alongside robust positive relationships with phosphate (r = 0.787, p < 0.001) and PTH (r = 0.799, p < 0.001). Left-sided RRI (RRI-Lt) mirrored these bilateral associations. In the diabetic population, RRI-Lt was positively correlated with phosphorus (r = 0.354, p = 0.012) and PTH (r = 0.386, p = 0.006), while its correlation with calcium did not reach statistical significance. In the non-diabetic group, RRI-Lt showed a strong significant negative correlation with calcium (r = -0.645, p < 0.001), and strong significant positive correlations with phosphorus (r = 0.782, p < 0.001) and PTH (r = 0.797, p < 0.001). Conclusion: Bilateral RRI values parallel hyperphosphatemia and secondary hyperparathyroidism in both diabetic and non-diabetic renal populations, demonstrating enhanced magnitude in non-diabetic CKD.
SN - 2682-4558
ER -