Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis.
8 affiliations
- 1Sussex Centre for Consciousness Science, University of Sussex, Brighton, UK.
- 2Department of Clinical Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
- 3School of Psychology, University of Sussex, Brighton, UK.
- 4Institute of Cognitive Neuroscience, University College London, London, UK.
- 5Monash Centre for Consciousness and Contemplative Studies, Monash University, Melbourne, Victoria, Australia.
- 6Department of Psychology, Royal Holloway, University of London, Egham, UK.
- 7School of Media, Arts and Humanities, University of Sussex, Brighton, UK.
- 8School of Engineering and Informatics, University of Sussex, Brighton, UK.
Abstract
Individual differences in susceptibility to somatosensory false physiological feedback reflect variations in interoceptive processing, yet the underlying neural network mechanisms remain unclear. We analyzed resting-state functional connectivity using graph theoretical approaches in 41 healthy adults who completed a somatosensory false feedback paradigm. Nine regions of interest were defined from previous activation analyses, and network topology metrics including local efficiency, clustering coefficient, centrality measures, and path length were calculated across multiple thresholds. Three distinct patterns of network organization predicted false feedback susceptibility. Individuals more susceptible to false feedback showed: (1) increased posterior insula eccentricity, indicating network peripheralization of this key interoceptive region; (2) consistent orbitofrontal cortex segregation across multiple metrics including increased path length and decreased centrality measures; and (3) cerebellar network reconfiguration with reduced local efficiency but increased betweenness centrality. Somatosensory false feedback susceptibility reflects specific alterations in functional network topology, particularly reduced integration of interoceptive regions (posterior insula) and emotional appraisal systems (orbitofrontal cortex). These findings support a network-based model where interoceptive processing depends on efficient integration between visceral sensation, emotional evaluation, and cognitive control systems. Understanding these network properties may inform interventions targeting interoceptive awareness and emotional regulation.
Related
- A geniculocortical circuit model predicts functional organization underlying efficient spatial frequency coding in the mouse visual system
- Generalizable sex differences in functional brain organization follow the cortical hierarchy in youth
- Transcriptomic differences underlying fin sexual dichromatism and male color polymorphism in bluefin killifish (Lucania goodei)
- Multi-omics reveals accumulation mechanisms underlying differences in sesquiterpenoid content across different growth environments of Atractylodes macrocephala rhizome
- Gut microbiota and multi-omics analysis identify candidate gut-muscle associations underlying breast muscle quality differences between Mimas pigeon and pigeon Tianxiang 1 strain
BibTeX
@article{patchitt2026functional,
title = {{Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis.}},
author = {J Patchitt and T Karapanagiotidis and S N Garfinkel and M Miller and M Tsakiris and A Clark and H D Critchley},
journal = {Human brain mapping},
year = {2026},
month = oct,
doi = {10.1002/hbm.70640},
url = {https://europepmc.org/article/MED/42963537},
note = {CC BY},
}
RIS
TY - JOUR
TI - Functional Network Organization Underlying Individual Differences in False Feedback Susceptibility: A Graph Theoretical Analysis.
AU - J Patchitt
AU - T Karapanagiotidis
AU - S N Garfinkel
AU - M Miller
AU - M Tsakiris
AU - A Clark
AU - H D Critchley
PY - 2026
DA - 2026/10/30
JO - Human brain mapping
DO - 10.1002/hbm.70640
UR - https://europepmc.org/article/MED/42963537
AB - Individual differences in susceptibility to somatosensory false physiological feedback reflect variations in interoceptive processing, yet the underlying neural network mechanisms remain unclear. We analyzed resting-state functional connectivity using graph theoretical approaches in 41 healthy adults who completed a somatosensory false feedback paradigm. Nine regions of interest were defined from previous activation analyses, and network topology metrics including local efficiency, clustering coefficient, centrality measures, and path length were calculated across multiple thresholds. Three distinct patterns of network organization predicted false feedback susceptibility. Individuals more susceptible to false feedback showed: (1) increased posterior insula eccentricity, indicating network peripheralization of this key interoceptive region; (2) consistent orbitofrontal cortex segregation across multiple metrics including increased path length and decreased centrality measures; and (3) cerebellar network reconfiguration with reduced local efficiency but increased betweenness centrality. Somatosensory false feedback susceptibility reflects specific alterations in functional network topology, particularly reduced integration of interoceptive regions (posterior insula) and emotional appraisal systems (orbitofrontal cortex). These findings support a network-based model where interoceptive processing depends on efficient integration between visceral sensation, emotional evaluation, and cognitive control systems. Understanding these network properties may inform interventions targeting interoceptive awareness and emotional regulation.
SN - 1065-9471
SN - 1097-0193
ER -