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Peer-reviewedLicence not statedNature

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC

  • Yiming Peng‐Winkler1,2,3
  • Xiao‐Zheng Liu2,3
  • Sanne M L Verheul4
  • Charlotte Girondel5
  • Sebastian Igelmann2,3
  • Sara Marie Rotter6
  • Michail Doukas7
  • Ming Liu2,3
  • Anke Vandekeere2,3
  • Mélanie Planque2,3,8
  • Juan Fernández-García2,3
  • Sébastien Tabariès5
22 more authors
  • Marta Buetas Arcas9,10
  • Sandra Martínez-Martín11
  • Florian Döbbe6
  • Margherita Demicco2,3
  • Ines Vermeire2,3
  • Janine Theile2,3
  • Johannes Ceuppens2,3,8
  • Jonas Haesevoets2,3
  • Emma Tobarra-López2,3
  • Dorien Broekaert2,3
  • Johannes Georg Bode1
  • Tom Luedde1
  • Peter Vermeulen4,12
  • Daniele V. F. Tauriello13,4
  • Raquel Pérez-López10
  • Steve Stegen14
  • Laura Soucek15,16,17,11
  • Tiago De Oliveira6
  • Lena‐Christin Conradi6
  • Peter M. Siegel5
  • Cornelis Kees Verhoef4
  • Sarah‐Maria Fendt18,19
19 affiliations
  1. 1Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Dusseldorf, Dusseldorf, Germany
  2. 2Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium
  3. 3Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium
  4. 4Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands
  5. 5Department of Medicine, Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada
  6. 6Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany
  7. 7Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands
  8. 8Spatial Metabolomics Expertise Center, VIB Center for Cancer Biology, VIB, Leuven, Belgium
  9. 9Facultat de Matemàtiques i Informàtica, Universitat de Barcelona, Barcelona, Spain
  10. 10Radiomics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain
  11. 11Peptomyc, Barcelona, Spain
  12. 12Translational Cancer Research Unit, Department of Oncological Research, ZAS Augustinus, Wilrijk, Belgium
  13. 13Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands
  14. 14Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium
  15. 15Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
  16. 16Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain
  17. 17Models of Cancer Therapies Laboratory, Vall d'Hebron Institute of Oncology, Cellex Centre, Hospital University Vall d'Hebron Campus, Barcelona, Spain
  18. 18Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. [email protected]
  19. 19Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium. [email protected]
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{pengwinkler2026steatosis,
  title = {{Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC}},
  author = {Yiming Peng‐Winkler and Xiao‐Zheng Liu and Sanne M L Verheul and Charlotte Girondel and Sebastian Igelmann and Sara Marie Rotter and Michail Doukas and Ming Liu and Anke Vandekeere and Mélanie Planque and Juan Fernández-García and Sébastien Tabariès and Marta Buetas Arcas and Sandra Martínez-Martín and Florian Döbbe and Margherita Demicco and Ines Vermeire and Janine Theile and Johannes Ceuppens and Jonas Haesevoets and Emma Tobarra-López and Dorien Broekaert and Johannes Georg Bode and Tom Luedde and Peter Vermeulen and Daniele V. F. Tauriello and Raquel Pérez-López and Steve Stegen and Laura Soucek and Tiago De Oliveira and Lena‐Christin Conradi and Peter M. Siegel and Cornelis Kees Verhoef and Sarah‐Maria Fendt},
  journal = {Nature},
  year = {2026},
  month = jul,
  doi = {10.1038/s41586-026-10686-2},
  url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC7619563/},
}
RIS
TY  - JOUR
TI  - Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC
AU  - Yiming Peng‐Winkler
AU  - Xiao‐Zheng Liu
AU  - Sanne M L Verheul
AU  - Charlotte Girondel
AU  - Sebastian Igelmann
AU  - Sara Marie Rotter
AU  - Michail Doukas
AU  - Ming Liu
AU  - Anke Vandekeere
AU  - Mélanie Planque
AU  - Juan Fernández-García
AU  - Sébastien Tabariès
AU  - Marta Buetas Arcas
AU  - Sandra Martínez-Martín
AU  - Florian Döbbe
AU  - Margherita Demicco
AU  - Ines Vermeire
AU  - Janine Theile
AU  - Johannes Ceuppens
AU  - Jonas Haesevoets
AU  - Emma Tobarra-López
AU  - Dorien Broekaert
AU  - Johannes Georg Bode
AU  - Tom Luedde
AU  - Peter Vermeulen
AU  - Daniele V. F. Tauriello
AU  - Raquel Pérez-López
AU  - Steve Stegen
AU  - Laura Soucek
AU  - Tiago De Oliveira
AU  - Lena‐Christin Conradi
AU  - Peter M. Siegel
AU  - Cornelis Kees Verhoef
AU  - Sarah‐Maria Fendt
PY  - 2026
DA  - 2026/07/01
JO  - Nature
DO  - 10.1038/s41586-026-10686-2
UR  - https://pmc.ncbi.nlm.nih.gov/articles/PMC7619563/
SN  - 0028-0836
SN  - 1476-4687
ER  -