Effects of pre-membrane acidification on extracorporeal CO2 removal compared with conventional ECCO2R in mechanically ventilated animal models: a preclinical systematic review protocol.
4 affiliations
- 1Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.
- 2Intensive Care Unit, Hospital Sírio-Libanês - São Paulo (SP), Brazil.
- 3Medical Intensive Care Unit, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.
- 4Pulmonary Division, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.
Abstract
Objective
To systematically evaluate the effect of pre-membrane blood acidification, compared with conventional extracorporeal carbon dioxide removal without acidification, on extracorporeal - carbon dioxide elimination in large animal models undergoing mechanical ventilation.Methods
This protocol is prospectively registered in PROSPERO and will be conducted in accordance with PRISMA-P guidelines. We will include preclinical experimental studies in large animals (e.g., swine, sheep, goats, cattle, or dogs) evaluating pre-membrane acidification associated with extracorporeal carbon dioxide removal. We will conduct electronic searches in PubMed®, Web of Science, Scopus, Embase, and Google Scholar from database inception to December 2025, without language restrictions. Two independent reviewers will conduct study selection, data extraction, and risk-of-bias assessment using the SYRCLE tool. The primary outcome will be extracorporeal carbon dioxide elimination. When appropriate, we will conduct meta-analyses using random-effects models. We will standardize carbon dioxide elimination values by body weight (mL/kg/minute) to improve comparability across species.Results
This review will provide a structured synthesis of preclinical evidence regarding the magnitude and consistency of the effect of pre-membrane acidification on carbon dioxide elimination, ventilatory parameters, and adverse events.Conclusion
By systematically evaluating available experimental data, this review aims to clarify the potential role of pre-membrane acidification as an adjunctive strategy to extracorporeal carbon dioxide removal and to identify knowledge gaps relevant for future translational and clinical research.
Related
- Diaphragmatic Rapid Shallow Breathing Index Versus Diaphragmatic Thickness Fraction for Predicting Weaning Success in Mechanically Ventilated Patients
- Postextubation Stridor: An Analysis of Incidence, Risk Factors, and Clinical Outcomes in Mechanically Ventilated Patients
- Predicting fluid responsiveness in mechanically ventilated children under general anaesthesia using dynamic parameters and transthoracic echocardiography
- Low arterial oxygen-content burden during the first 24 h and hospital mortality in mechanically ventilated adults: analyses of MIMIC-IV and eICU
- Assessing the Influence of Propofol Sedation Versus Propofol-Free Sedation on Recovery From Sepsis and Septic Shock in Mechanically Ventilated ICU Patients: A Retrospective, Propensity-Score Matched, Cohort Study
BibTeX
@article{junior2026effects,
title = {{Effects of pre-membrane acidification on extracorporeal CO2 removal compared with conventional ECCO2R in mechanically ventilated animal models: a preclinical systematic review protocol.}},
author = {Vagner Pires de Campos Júnior and Anne Caroline de Almeida Sousa and Yuri de Albuquerque Pessoa Dos Santos and Maristela Carvalho and Marcelo Amato Britto Passos and Eduardo Leite Vieira Costa},
journal = {Critical care science},
year = {2026},
month = oct,
doi = {10.62675/2965-2774.20260105},
url = {https://europepmc.org/article/MED/42961286},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of pre-membrane acidification on extracorporeal CO2 removal compared with conventional ECCO2R in mechanically ventilated animal models: a preclinical systematic review protocol.
AU - Vagner Pires de Campos Júnior
AU - Anne Caroline de Almeida Sousa
AU - Yuri de Albuquerque Pessoa Dos Santos
AU - Maristela Carvalho
AU - Marcelo Amato Britto Passos
AU - Eduardo Leite Vieira Costa
PY - 2026
DA - 2026/10/23
JO - Critical care science
DO - 10.62675/2965-2774.20260105
UR - https://europepmc.org/article/MED/42961286
AB - Objective To systematically evaluate the effect of pre-membrane blood acidification, compared with conventional extracorporeal carbon dioxide removal without acidification, on extracorporeal - carbon dioxide elimination in large animal models undergoing mechanical ventilation.Methods This protocol is prospectively registered in PROSPERO and will be conducted in accordance with PRISMA-P guidelines. We will include preclinical experimental studies in large animals (e.g., swine, sheep, goats, cattle, or dogs) evaluating pre-membrane acidification associated with extracorporeal carbon dioxide removal. We will conduct electronic searches in PubMed®, Web of Science, Scopus, Embase, and Google Scholar from database inception to December 2025, without language restrictions. Two independent reviewers will conduct study selection, data extraction, and risk-of-bias assessment using the SYRCLE tool. The primary outcome will be extracorporeal carbon dioxide elimination. When appropriate, we will conduct meta-analyses using random-effects models. We will standardize carbon dioxide elimination values by body weight (mL/kg/minute) to improve comparability across species.Results This review will provide a structured synthesis of preclinical evidence regarding the magnitude and consistency of the effect of pre-membrane acidification on carbon dioxide elimination, ventilatory parameters, and adverse events.Conclusion By systematically evaluating available experimental data, this review aims to clarify the potential role of pre-membrane acidification as an adjunctive strategy to extracorporeal carbon dioxide removal and to identify knowledge gaps relevant for future translational and clinical research.
SN - 2965-2774
ER -