Emerging Roles of Src Family Protein Tyrosine Kinases in Diabetic Peripheral Neuropathy: Current Evidence and Therapeutic Perspectives.
- 1Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
- 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People's Republic of China.
- 3Institute of Clinical Medicine, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
Abstract
Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus and is characterized primarily by distal symmetric polyneuropathy. Its pathogenesis involves multiple interconnected processes, including hyperglycemia, metabolic dysregulation, oxidative stress, neuroinflammation, and pain sensitization. Src family kinases (SFKs) are a group of non-receptor protein tyrosine kinases that are widely involved in cell proliferation, migration, inflammatory responses, synaptic plasticity, and ion-channel regulation. Recent evidence indicates that high glucose, advanced glycation end products, inflammatory mediators, and nerve injury-related stimuli can induce aberrant activation of SFKs, which may contribute to DPN-related neural injury and neuropathic pain. However, research on the involvement of SFKs in DPN remains relatively limited, and their specific roles and therapeutic value in DPN require further validation. On the basis of an overview of the structural features of SFKs, this review summarizes current evidence regarding the multiple mechanisms through which SFKs may participate in DPN and discusses the therapeutic prospects of SFK inhibitors, SFK-directed strategies, and traditional Chinese medicine approaches in DPN. The aim is to provide a reference for the development of SFK-targeted therapeutic approaches for DPN.
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BibTeX
@article{wang2026emerging,
title = {{Emerging Roles of Src Family Protein Tyrosine Kinases in Diabetic Peripheral Neuropathy: Current Evidence and Therapeutic Perspectives.}},
author = {Wenting Wang and Ziyu Li and Zanpeng Chen and Yuan Cao and Hui Cao and Shuainan Liu and Wei Song and Qunli Wu},
journal = {Diabetes, metabolic syndrome and obesity : targets and therapy},
year = {2026},
month = oct,
doi = {10.2147/dmso.s637555},
url = {https://europepmc.org/article/MED/42936185},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Emerging Roles of Src Family Protein Tyrosine Kinases in Diabetic Peripheral Neuropathy: Current Evidence and Therapeutic Perspectives.
AU - Wenting Wang
AU - Ziyu Li
AU - Zanpeng Chen
AU - Yuan Cao
AU - Hui Cao
AU - Shuainan Liu
AU - Wei Song
AU - Qunli Wu
PY - 2026
DA - 2026/10/22
JO - Diabetes, metabolic syndrome and obesity : targets and therapy
DO - 10.2147/dmso.s637555
UR - https://europepmc.org/article/MED/42936185
AB - Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus and is characterized primarily by distal symmetric polyneuropathy. Its pathogenesis involves multiple interconnected processes, including hyperglycemia, metabolic dysregulation, oxidative stress, neuroinflammation, and pain sensitization. Src family kinases (SFKs) are a group of non-receptor protein tyrosine kinases that are widely involved in cell proliferation, migration, inflammatory responses, synaptic plasticity, and ion-channel regulation. Recent evidence indicates that high glucose, advanced glycation end products, inflammatory mediators, and nerve injury-related stimuli can induce aberrant activation of SFKs, which may contribute to DPN-related neural injury and neuropathic pain. However, research on the involvement of SFKs in DPN remains relatively limited, and their specific roles and therapeutic value in DPN require further validation. On the basis of an overview of the structural features of SFKs, this review summarizes current evidence regarding the multiple mechanisms through which SFKs may participate in DPN and discusses the therapeutic prospects of SFK inhibitors, SFK-directed strategies, and traditional Chinese medicine approaches in DPN. The aim is to provide a reference for the development of SFK-targeted therapeutic approaches for DPN.
SN - 1178-7007
ER -