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Peer-reviewedCC BY 4.0Neurobiology of Disease

Brain energy metabolism in neurodegenerative disease

  • Carmen Maria Lahr1
  • Elle Wilson1
  • Melanie Sengupta1
  • Michela Bernini1
  • Alexander Skupin1,2,3
  1. 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 6, Avenue du Swing, Esch-sur-Alzette, Luxembourg
  2. 2Department of Physics, University Luxembourg, 7, Avenue de la Faiencerie, Luxembourg, Luxembourg
  3. 3Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
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Abstract

The brain is a highly complex organ composed of diverse, specialized cell types whose coordinated functions underpin cognition and behavior. While extensive research has elucidated neuronal signaling mechanisms, the metabolic interactions between distinct brain cells that sustain energy homeostasis are not yet comprehensively understood. Recently, brain energy metabolism has gained significant attention as a unifying factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's, potentially opening new avenues for therapeutic development. In this review, we provide an overview of brain energy metabolism, examine its role in neurodegeneration, and highlight current challenges and future perspectives in the field.

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Cite

BibTeXRIS
BibTeX
@article{lahr2026brain,
  title = {{Brain energy metabolism in neurodegenerative disease}},
  author = {Carmen Maria Lahr and Elle Wilson and Melanie Sengupta and Michela Bernini and Alexander Skupin},
  journal = {Neurobiology of Disease},
  year = {2026},
  month = nov,
  doi = {10.1016/j.nbd.2026.107615},
  url = {https://doi.org/10.1016/j.nbd.2026.107615},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Brain energy metabolism in neurodegenerative disease
AU  - Carmen Maria Lahr
AU  - Elle Wilson
AU  - Melanie Sengupta
AU  - Michela Bernini
AU  - Alexander Skupin
PY  - 2026
DA  - 2026/11/01
JO  - Neurobiology of Disease
DO  - 10.1016/j.nbd.2026.107615
UR  - https://doi.org/10.1016/j.nbd.2026.107615
AB  - The brain is a highly complex organ composed of diverse, specialized cell types whose coordinated functions underpin cognition and behavior. While extensive research has elucidated neuronal signaling mechanisms, the metabolic interactions between distinct brain cells that sustain energy homeostasis are not yet comprehensively understood. Recently, brain energy metabolism has gained significant attention as a unifying factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's, potentially opening new avenues for therapeutic development. In this review, we provide an overview of brain energy metabolism, examine its role in neurodegeneration, and highlight current challenges and future perspectives in the field.
SN  - 0969-9961
SN  - 1095-953X
ER  -