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Peer-reviewedCC BY-NC-NDInternal Medicine

Podocytic Infolding Gromerulopathy Developed at the Time of Transition from Chronic Myelogenous Leukemia to Myelodysplastic Syndrome

  • Aya Nakamori
  • Norimitsu Saito
  • Fuyuko Akagaki
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Abstract

Myelodysplastic syndrome (MDS) often coexists with systemic autoimmune diseases. Chronic myelogenous leukemia (CML) is an independent risk factor for intrarenal arterial hyalinosis. We describe a case of glomerulopathy that developed at the transition from CML with 5q deletion (relatively rare) to MDS with 5q and 13q deletion. Kidney histology showed glomerular hyalinosis due to intrarenal arterial changes from CML, in addition to podocytic infolding glomerulopathy (PIG) due to systemic immune responses from MDS or tyrosine kinase inhibitors, or which was coincidental. To our knowledge, this is the first case of PIG developing during the transition from CML to MDS.

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Cite

BibTeXRIS
BibTeX
@article{nakamori2026podocytic,
  title = {{Podocytic Infolding Gromerulopathy Developed at the Time of Transition from Chronic Myelogenous Leukemia to Myelodysplastic Syndrome}},
  author = {Aya Nakamori and Norimitsu Saito and Fuyuko Akagaki},
  journal = {Internal Medicine},
  year = {2026},
  month = aug,
  doi = {10.2169/internalmedicine.6455-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_6455-25/_article},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Podocytic Infolding Gromerulopathy Developed at the Time of Transition from Chronic Myelogenous Leukemia to Myelodysplastic Syndrome
AU  - Aya Nakamori
AU  - Norimitsu Saito
AU  - Fuyuko Akagaki
PY  - 2026
DA  - 2026/08/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6455-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/16/65_6455-25/_article
AB  - Myelodysplastic syndrome (MDS) often coexists with systemic autoimmune diseases. Chronic myelogenous leukemia (CML) is an independent risk factor for intrarenal arterial hyalinosis. We describe a case of glomerulopathy that developed at the transition from CML with 5q deletion (relatively rare) to MDS with 5q and 13q deletion. Kidney histology showed glomerular hyalinosis due to intrarenal arterial changes from CML, in addition to podocytic infolding glomerulopathy (PIG) due to systemic immune responses from MDS or tyrosine kinase inhibitors, or which was coincidental. To our knowledge, this is the first case of PIG developing during the transition from CML to MDS.
SN  - 1349-7235
SN  - 0918-2918
ER  -