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Peer-reviewedCC BYCureus

Association of Helicobacter pylori Infection With the Severity of Psoriasis.

  • Marufa Shahrin1
  • Mohammod Abu Hena Chowdhury2
  • Tanzina Begum Chowdhury3
  • Md Abir Hassan4
  • Arjun Saha5
  • Towfiq Ahmad6
  • Pranam Swapan Dash2
6 affiliations
  1. 1Department of Dermatology, Shaheed Suhrawardy Medical College, Dhaka, BGD.
  2. 2Department of Dermatology, Bangladesh Medical University, Dhaka, BGD.
  3. 3Department of Dermatology, Sarkari Karmachari Hospital, Dhaka, BGD.
  4. 4Department of Dermatology, Sir Salimullah Medical College, Dhaka, BGD.
  5. 5Department of Dermatology, Directorate General of Health Services, Dhaka, BGD.
  6. 6Department of Dermatology, Rajshahi Medical College Hospital, Rajshahi, BGD.
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Abstract

Background

Psoriasis is an inflammatory, immune-mediated disease with a multifactorial etiopathogenesis and a wide spectrum of clinical presentation. It has been proposed that Helicobacter pylori (H. pylori) infection acts as a possible etiological factor for psoriasis.Methods

Twenty-nine patients diagnosed with psoriasis were included in Group A, and an equal number of non-psoriatic individuals were included in Group B based on predefined inclusion and exclusion criteria. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI) score.Results

The epidemiological profile showed no significant differences in age or sex between patients and healthy individuals (age p=0.480; sex p=0.597). Among psoriasis patients, 23 (79.3%) had the disease for less than 10 years, and the mean disease duration was 4.76 ± 4.78 years (range: one to 20 years). A significant association was found between H. pylori infection and psoriasis, with nine (31.0%) of psoriasis patients testing positive for H. pylori stool antigen compared to only two (6.9%) in controls (p=0.019).Conclusion

H. pylori infection has a significant association with the severity of psoriasis. This finding highlights a probable role of bacterial infection in exacerbating immune-mediated skin conditions. Therefore, it can be proposed that psoriasis patients with high PASI scores may be screened for H. pylori infection by a fecal antigen test.

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Cite

BibTeXRIS
BibTeX
@article{shahrin2026association,
  title = {{Association of Helicobacter pylori Infection With the Severity of Psoriasis.}},
  author = {Marufa Shahrin and Mohammod Abu Hena Chowdhury and Tanzina Begum Chowdhury and Md Abir Hassan and Arjun Saha and Towfiq Ahmad and Pranam Swapan Dash},
  journal = {Cureus},
  year = {2026},
  month = sep,
  doi = {10.7759/cureus.116710},
  url = {https://europepmc.org/article/MED/42923307},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association of Helicobacter pylori Infection With the Severity of Psoriasis.
AU  - Marufa Shahrin
AU  - Mohammod Abu Hena Chowdhury
AU  - Tanzina Begum Chowdhury
AU  - Md Abir Hassan
AU  - Arjun Saha
AU  - Towfiq Ahmad
AU  - Pranam Swapan Dash
PY  - 2026
DA  - 2026/09/22
JO  - Cureus
DO  - 10.7759/cureus.116710
UR  - https://europepmc.org/article/MED/42923307
AB  - Background  Psoriasis is an inflammatory, immune-mediated disease with a multifactorial etiopathogenesis and a wide spectrum of clinical presentation. It has been proposed that Helicobacter pylori (H. pylori) infection acts as a possible etiological factor for psoriasis.Methods  Twenty-nine patients diagnosed with psoriasis were included in Group A, and an equal number of non-psoriatic individuals were included in Group B based on predefined inclusion and exclusion criteria. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI) score.Results  The epidemiological profile showed no significant differences in age or sex between patients and healthy individuals (age p=0.480; sex p=0.597). Among psoriasis patients, 23 (79.3%) had the disease for less than 10 years, and the mean disease duration was 4.76 ± 4.78 years (range: one to 20 years). A significant association was found between H. pylori infection and psoriasis, with nine (31.0%) of psoriasis patients testing positive for H. pylori stool antigen compared to only two (6.9%) in controls (p=0.019).Conclusion  H. pylori infection has a significant association with the severity of psoriasis. This finding highlights a probable role of bacterial infection in exacerbating immune-mediated skin conditions. Therefore, it can be proposed that psoriasis patients with high PASI scores may be screened for H. pylori infection by a fecal antigen test.
SN  - 2168-8184
ER  -