Human Papillomavirus Genotypes Among Women With Invasive Cervical Cancer in Nigeria: A Scoping Review
8 affiliations
- 1Washington University School of Medicine, St Louis, MO
- 2Department of Epidemiology at the University of North Carolina at Chapel Hill's Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
- 3Brown School at Washington University in St Louis, St Louis, MO
- 4Wake Forest School of Medicine, Winston-Salem, NC
- 5University of Ibadan, Ibadan, Oyo State, Nigeria
- 6Nigerian Institute of Medical Research, Lagos, Nigeria
- 7Saint Louis University Medical School, St Louis, MO
- 8University of North Carolina at Chapel Hill, Chapel Hill, NC
Abstract
PurposeInvasive cervical cancer (ICC) cases remain a major public health concern for women in Nigeria. The purpose of this scoping review is to assess the reporting of common human papillomavirus (HPV) genotypes found in ICC cases among Nigerian women.MethodsWe searched five databases, including Embase, Ovid Medline, Scopus, Cochrane Database of Systematic Reviews, and Google Scholar, to identify studies reporting HPV genotypes found in ICC cases in Nigeria. Study selection and data extraction were conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines. Two researchers extracted data from each eligible article.ResultsA total of 668 records were identified, of which 422 studies were screened and six articles met the eligibility criteria. The included studies reported on HPV genotypes detected in ICC among Nigerian women. Across the studies, high-risk HPV (hrHPV) types 16, 18, 35, and 45 were identified in approximately 50% of ICC cases, whereas other detected genotypes included hrHPV types 31, 33, 51, and 52. Notably, in addition to globally predominant hrHPV types 16 and 18, hrHPV types 35 and 45 were also frequently detected, indicating their significant contribution to the ICC burden among Nigerian women.ConclusionAfter an extensive search, this study provides a comprehensive assessment of the overall prevalence and distribution of hrHPV genotypes in Nigerian women with ICC. The most common hrHPV genotypes detected in ICC in Nigeria are 16, 18, 35, 45, 31, 33, 51, and 52. hrHPV types 16 and 18 account for the majority of cases, but in Nigeria and among women of African descent worldwide, hrHPV types 45 and 35 are also significantly present in ICC cases.
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BibTeX
@article{obodoechina2026human,
title = {{Human Papillomavirus Genotypes Among Women With Invasive Cervical Cancer in Nigeria: A Scoping Review}},
author = {Nkiruka Obodoechina and Jennifer S. Smith and Peter Kalulu and Olufunto A. Olusanya and Onyekachukwu Anikamadu and Ucheoma Nwaozuru and Temitope Ojo and Ifeoluwatoolami Olaolorun and Folahanmi Akinsolu and Chika Onwuamah and Emily Gallaher and Yie Hwa Chang and Oliver Ezechi and Joseph Tucker and Juliet Iwelunmor},
journal = {JCO Global Oncology},
year = {2026},
month = nov,
doi = {10.1200/go-25-00022},
url = {https://doi.org/10.1200/go-25-00022},
note = {CC BY},
}
RIS
TY - JOUR
TI - Human Papillomavirus Genotypes Among Women With Invasive Cervical Cancer in Nigeria: A Scoping Review
AU - Nkiruka Obodoechina
AU - Jennifer S. Smith
AU - Peter Kalulu
AU - Olufunto A. Olusanya
AU - Onyekachukwu Anikamadu
AU - Ucheoma Nwaozuru
AU - Temitope Ojo
AU - Ifeoluwatoolami Olaolorun
AU - Folahanmi Akinsolu
AU - Chika Onwuamah
AU - Emily Gallaher
AU - Yie Hwa Chang
AU - Oliver Ezechi
AU - Joseph Tucker
AU - Juliet Iwelunmor
PY - 2026
DA - 2026/11/04
JO - JCO Global Oncology
DO - 10.1200/go-25-00022
UR - https://doi.org/10.1200/go-25-00022
AB - PurposeInvasive cervical cancer (ICC) cases remain a major public health concern for women in Nigeria. The purpose of this scoping review is to assess the reporting of common human papillomavirus (HPV) genotypes found in ICC cases among Nigerian women.MethodsWe searched five databases, including Embase, Ovid Medline, Scopus, Cochrane Database of Systematic Reviews, and Google Scholar, to identify studies reporting HPV genotypes found in ICC cases in Nigeria. Study selection and data extraction were conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines. Two researchers extracted data from each eligible article.ResultsA total of 668 records were identified, of which 422 studies were screened and six articles met the eligibility criteria. The included studies reported on HPV genotypes detected in ICC among Nigerian women. Across the studies, high-risk HPV (hrHPV) types 16, 18, 35, and 45 were identified in approximately 50% of ICC cases, whereas other detected genotypes included hrHPV types 31, 33, 51, and 52. Notably, in addition to globally predominant hrHPV types 16 and 18, hrHPV types 35 and 45 were also frequently detected, indicating their significant contribution to the ICC burden among Nigerian women.ConclusionAfter an extensive search, this study provides a comprehensive assessment of the overall prevalence and distribution of hrHPV genotypes in Nigerian women with ICC. The most common hrHPV genotypes detected in ICC in Nigeria are 16, 18, 35, 45, 31, 33, 51, and 52. hrHPV types 16 and 18 account for the majority of cases, but in Nigeria and among women of African descent worldwide, hrHPV types 45 and 35 are also significantly present in ICC cases.
SN - 2687-8941
ER -