Epidemiological and nursing perspectives on insulin-derived amyloidosis: a scoping review.
- 1Department of Nursing Science, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
- 2Faculty of Nursing, School of Health Sciences, Fujita Health University, Toyoake, Aichi, Japan.
- 3Department of Clinical Pharmacology, School of Nursing, Faculty of Medicine, University of Miyazaki, Miyazaki, Miyazaki, Japan.
Abstract
Objectives
Insulin-related amyloidosis (IDA) is a subcutaneous complication that may interfere with insulin absorption. Although early detection may prevent the deterioration of glycemic control, this condition is often overlooked. In this scoping review, we aimed to summarize the epidemiological characteristics of IDA and identify future research challenges from a nursing perspective.Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews guidelines, a comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and the Japan Medical Abstracts Society database. The eligible studies comprised original articles and case reports regarding patients with histopathologically confirmed IDA published in English or Japanese between January 2009 and August 2022.Results
No epidemiological research articles, but a total of 29 case-based reports regarding 38 patients, were identified. Most of the patients were male (n=29), they were aged 27-87 years, and both type 1 and type 2 diabetes were represented. The abdominal region was the most common site of lesions (n=23). Histopathology was the primary diagnostic method, although some patients were also evaluated using diagnostic imaging. Many of the patients noticed subcutaneous masses but delayed seeking medical care, and some continued injecting insulin into the affected sites. Medical consultations were often prompted by poor glycemic control or complications of diabetes.Conclusions
This review highlights the paucity of epidemiological research on IDA and underscores the importance of early detection and education. Limited awareness regarding injection-site abnormalities and the lack of early assessments may contribute to delays in diagnosis.
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BibTeX
@article{hisano2026epidemiological,
title = {{Epidemiological and nursing perspectives on insulin-derived amyloidosis: a scoping review.}},
author = {Fumiya Hisano and Kimie Takehara and Keisuke Nakanishi and Miharu Tamaoki and Toshihiko Yanagita and Junko Sugama},
journal = {Fujita medical journal},
year = {2026},
month = sep,
doi = {10.20407/fmj.2026-009},
url = {https://europepmc.org/article/MED/42968998},
note = {CC BY},
}
RIS
TY - JOUR
TI - Epidemiological and nursing perspectives on insulin-derived amyloidosis: a scoping review.
AU - Fumiya Hisano
AU - Kimie Takehara
AU - Keisuke Nakanishi
AU - Miharu Tamaoki
AU - Toshihiko Yanagita
AU - Junko Sugama
PY - 2026
DA - 2026/09/25
JO - Fujita medical journal
DO - 10.20407/fmj.2026-009
UR - https://europepmc.org/article/MED/42968998
AB - Objectives Insulin-related amyloidosis (IDA) is a subcutaneous complication that may interfere with insulin absorption. Although early detection may prevent the deterioration of glycemic control, this condition is often overlooked. In this scoping review, we aimed to summarize the epidemiological characteristics of IDA and identify future research challenges from a nursing perspective.Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews guidelines, a comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and the Japan Medical Abstracts Society database. The eligible studies comprised original articles and case reports regarding patients with histopathologically confirmed IDA published in English or Japanese between January 2009 and August 2022.Results No epidemiological research articles, but a total of 29 case-based reports regarding 38 patients, were identified. Most of the patients were male (n=29), they were aged 27-87 years, and both type 1 and type 2 diabetes were represented. The abdominal region was the most common site of lesions (n=23). Histopathology was the primary diagnostic method, although some patients were also evaluated using diagnostic imaging. Many of the patients noticed subcutaneous masses but delayed seeking medical care, and some continued injecting insulin into the affected sites. Medical consultations were often prompted by poor glycemic control or complications of diabetes.Conclusions This review highlights the paucity of epidemiological research on IDA and underscores the importance of early detection and education. Limited awareness regarding injection-site abnormalities and the lack of early assessments may contribute to delays in diagnosis.
SN - 2189-7247
SN - 2189-7255
ER -