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Peer-reviewedCC BY-NC 4.0Diabetes, Metabolic Syndrome and Obesity

Interactive Pathways and Therapeutic Innovations in Elderly Sarcopenia-Diabetes Comorbidity: Breaking the Negative Self-Reinforcing Loop Through Integrated Care

  • Fengying Gong1,2
  • Qiang Zhang1
  • Rongmei Qu3
  • Lin Zhou4
  • Ying Lv1
  • Jingjun Li1
  • Jingxing Dai5
5 affiliations
  1. 1Department of Traditional Chinese Medicine, Nanfang Hospital of Southern Medical University, Guangzhou, People’s Republic of China
  2. 2The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China
  3. 3Fok Ying Tung Research Institute, Guangzhou HKUST, Guangzhou, People’s Republic of China
  4. 4Department of Endocrinology, Nanfang Hospital of Southern Medical University, Guangzhou, People’s Republic of China
  5. 5Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China
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Abstract

Against the backdrop of a rapidly aging global population, the prevalence of metabolic dysregulation and degenerative musculoskeletal conditions is escalating. Projections indicate that sarcopenia will emerge as a major public health burden over the next three decades. A robust bidirectional link connects sarcopenia with type 2 diabetes mellitus (T2DM); each condition substantially elevates the risk of the other and may accelerate functional decline and disability. Emerging data demonstrate that older adults with both T2DM and sarcopenia face a markedly higher risk of all-cause mortality than those with T2DM alone. Consequently, unraveling the shared pathophysiological underpinnings of these comorbid disorders holds profound clinical and scientific significance. We reviewed current knowledge on the interactive mechanisms driving the sarcopenia–diabetes nexus and evaluated existing therapeutic approaches through systematic searches of PubMed, Google Scholar, and Science Direct. The high co-occurrence of sarcopenia and T2DM in older adults is not coincidental; rather, it reflects a well-documented pathophysiological interrelationship. By synthesizing contemporary evidence, we aim to guide future research and refine clinical protocols designed to improve quality of life and reduce complication rates among elderly diabetic populations.

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Cite

BibTeXRIS
BibTeX
@article{gong2026interactive,
  title = {{Interactive Pathways and Therapeutic Innovations in Elderly Sarcopenia-Diabetes Comorbidity: Breaking the Negative Self-Reinforcing Loop Through Integrated Care}},
  author = {Fengying Gong and Qiang Zhang and Rongmei Qu and Lin Zhou and Ying Lv and Jingjun Li and Jingxing Dai},
  journal = {Diabetes, Metabolic Syndrome and Obesity},
  year = {2026},
  month = oct,
  doi = {10.2147/dmso.s630510},
  url = {https://doi.org/10.2147/dmso.s630510},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Interactive Pathways and Therapeutic Innovations in Elderly Sarcopenia-Diabetes Comorbidity: Breaking the Negative Self-Reinforcing Loop Through Integrated Care
AU  - Fengying Gong
AU  - Qiang Zhang
AU  - Rongmei Qu
AU  - Lin Zhou
AU  - Ying Lv
AU  - Jingjun Li
AU  - Jingxing Dai
PY  - 2026
DA  - 2026/10/28
JO  - Diabetes, Metabolic Syndrome and Obesity
DO  - 10.2147/dmso.s630510
UR  - https://doi.org/10.2147/dmso.s630510
AB  - Against the backdrop of a rapidly aging global population, the prevalence of metabolic dysregulation and degenerative musculoskeletal conditions is escalating. Projections indicate that sarcopenia will emerge as a major public health burden over the next three decades. A robust bidirectional link connects sarcopenia with type 2 diabetes mellitus (T2DM); each condition substantially elevates the risk of the other and may accelerate functional decline and disability. Emerging data demonstrate that older adults with both T2DM and sarcopenia face a markedly higher risk of all-cause mortality than those with T2DM alone. Consequently, unraveling the shared pathophysiological underpinnings of these comorbid disorders holds profound clinical and scientific significance. We reviewed current knowledge on the interactive mechanisms driving the sarcopenia–diabetes nexus and evaluated existing therapeutic approaches through systematic searches of PubMed, Google Scholar, and Science Direct. The high co-occurrence of sarcopenia and T2DM in older adults is not coincidental; rather, it reflects a well-documented pathophysiological interrelationship. By synthesizing contemporary evidence, we aim to guide future research and refine clinical protocols designed to improve quality of life and reduce complication rates among elderly diabetic populations.
SN  - 1178-7007
ER  -