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Peer-reviewedCC BY-NC-ND 4.0In Vivo

Significance of Plasma Pro-collagen Type I α1 Chain in Patients With Colorectal Cancer

  • JAN DIMBERG1
  • LEVAR SHAMOUN2
  • SON DINH AN TRUONG3
  • KALLE LANDERHOLM4,5
  • EMMA DRUVEFORS4,6
  • DICK WÅGSÄTER7
7 affiliations
  1. 1Department of Clinical Diagnostics, School of Health and Welfare, Jönköping University, Jönköping, Sweden
  2. 2Department of Laboratory Medicine and Pathology, Ryhov Hospital, Jönköping, Sweden
  3. 3Department of Laboratory, Vinmec Danang International General Hospital, Danang, Vietnam
  4. 4Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
  5. 5Clinical Department of Surgery in Linköping, Region Östergötland, Sweden
  6. 6Department of Surgery, Ryhov Hospital, Region Jönköping County, Jönköping, Sweden
  7. 7Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
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Abstract

Background/Aim: Expression of the gene encoding collagen type I α1 chain (COL1A1) in cancer tissue primarily results in production of the pro-form of COL1A1, which can be released into the bloodstream. This study aimed to investigate whether plasma levels of pro-COL1A1 are associated with clinicopathological characteristics and long-term survival in patients with colorectal cancer (CRC).

Materials and Methods: Plasma levels of pro-pro-COL1A1 were measured in 148 patients with CRC and 28 healthy controls using an enzyme-linked immunosorbent assay (ELISA).

Results: Plasma levels of pro-COL1A1 were significantly lower in patients with CRC compared with healthy controls (p<0.001). Lower levels were also observed in men compared with women. Kaplan-Meier survival analysis demonstrated that a low plasma level of pro-COL1A1 was associated with poorer overall survival considering the entire cohort, as well as in subgroups of patients with colon cancer, depth of tumor invasion T3+T4, node-negative (N0) disease and in females.

Conclusion: These findings suggest that plasma levels of pro-COL1A1 may serve as a prognostic biomarker for long-term survival in patients with CRC.

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Cite

BibTeXRIS
BibTeX
@article{dimberg2026significance,
  title = {{Significance of Plasma Pro-collagen Type I α1 Chain in Patients With Colorectal Cancer}},
  author = {JAN DIMBERG and LEVAR SHAMOUN and SON DINH AN TRUONG and KALLE LANDERHOLM and EMMA DRUVEFORS and DICK WÅGSÄTER},
  journal = {In Vivo},
  year = {2026},
  month = oct,
  doi = {10.21873/invivo.14501},
  url = {https://doi.org/10.21873/invivo.14501},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Significance of Plasma Pro-collagen Type I α1 Chain in Patients With Colorectal Cancer
AU  - JAN DIMBERG
AU  - LEVAR SHAMOUN
AU  - SON DINH AN TRUONG
AU  - KALLE LANDERHOLM
AU  - EMMA DRUVEFORS
AU  - DICK WÅGSÄTER
PY  - 2026
DA  - 2026/10/29
JO  - In Vivo
DO  - 10.21873/invivo.14501
UR  - https://doi.org/10.21873/invivo.14501
AB  - Background/Aim: Expression of the gene encoding collagen type I α1 chain (COL1A1) in cancer tissue primarily results in production of the pro-form of COL1A1, which can be released into the bloodstream. This study aimed to investigate whether plasma levels of pro-COL1A1 are associated with clinicopathological characteristics and long-term survival in patients with colorectal cancer (CRC).  Materials and Methods: Plasma levels of pro-pro-COL1A1 were measured in 148 patients with CRC and 28 healthy controls using an enzyme-linked immunosorbent assay (ELISA).  Results: Plasma levels of pro-COL1A1 were significantly lower in patients with CRC compared with healthy controls (p<0.001). Lower levels were also observed in men compared with women. Kaplan-Meier survival analysis demonstrated that a low plasma level of pro-COL1A1 was associated with poorer overall survival considering the entire cohort, as well as in subgroups of patients with colon cancer, depth of tumor invasion T3+T4, node-negative (N0) disease and in females.  Conclusion: These findings suggest that plasma levels of pro-COL1A1 may serve as a prognostic biomarker for long-term survival in patients with CRC.
SN  - 0258-851X
SN  - 1791-7549
ER  -