Circadian rhythm dysregulation and ferroptosis in hypertension: mechanisms and therapeutic implications
- 1Department of Cardiology, Shanghai Yangpu Hospital of Traditional Chinese Medicine
- 2Faculty of Chinese Medicine, Macau University of Science and Technology
Abstract
Hypertension exhibits a pronounced circadian rhythm; however, the mechanisms by which circadian disruption translates temporal imbalance into sustained vascular and renal injury remain unclear. Increasing evidence suggests that circadian misalignment may promote endothelial dysfunction, vascular remodeling, and renal injury through ferroptosis driven by oxidative stress dysregulation, thereby increasing the risk of hypertension. Based on current evidence, this review proposes that circadian disruption induces a temporal mismatch between oxidative stress generation and antioxidant defense, thereby lowering the threshold for ferroptosis in cardiovascular and renal tissues. This process may amplify hemodynamic stress, impair endothelial integrity, and disturb renal sodium handling, ultimately contributing to the development and progression of hypertension. Although direct causal evidence remains limited, this review integrates circadian biology with ferroptosis and provides a mechanistic link between time-dependent physiological regulation and structural organ damage, highlighting a potentially promising strategy for future hypertension intervention.
Related
- Endothelial Redox Dysregulation in Pulmonary Arterial Hypertension: Compartmentalized Mechanisms and Therapeutic Implications
- Lipid Metabolism and Ferroptosis in Cancer: Regulatory Mechanisms, Alternative Splicing, and Therapeutic Implications
- Redox Dysregulation in the Abdominal Aortic Aneurysm Wall: Ferroptosis and Experimental Therapeutic Opportunities
- Germinal center and extrafollicular dysregulation in systemic lupus erythematosus: Mechanisms and therapeutic opportunities
- Chronic Occupational Stress and Immune–Inflammatory Dysregulation: Mechanisms, Clinical Consequences, Biomarkers and Implications for Occupational Medicine
BibTeX
@article{zeng2026circadian,
title = {{Circadian rhythm dysregulation and ferroptosis in hypertension: mechanisms and therapeutic implications}},
author = {Hui Zeng and Jiawen Lin and Jun Chen},
journal = {Frontiers in Cardiovascular Medicine},
year = {2026},
month = oct,
doi = {10.3389/fcvm.2026.1889670},
url = {https://www.frontiersin.org/articles/10.3389/fcvm.2026.1889670/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Circadian rhythm dysregulation and ferroptosis in hypertension: mechanisms and therapeutic implications
AU - Hui Zeng
AU - Jiawen Lin
AU - Jun Chen
PY - 2026
DA - 2026/10/16
JO - Frontiers in Cardiovascular Medicine
DO - 10.3389/fcvm.2026.1889670
UR - https://www.frontiersin.org/articles/10.3389/fcvm.2026.1889670/full
AB - Hypertension exhibits a pronounced circadian rhythm; however, the mechanisms by which circadian disruption translates temporal imbalance into sustained vascular and renal injury remain unclear. Increasing evidence suggests that circadian misalignment may promote endothelial dysfunction, vascular remodeling, and renal injury through ferroptosis driven by oxidative stress dysregulation, thereby increasing the risk of hypertension. Based on current evidence, this review proposes that circadian disruption induces a temporal mismatch between oxidative stress generation and antioxidant defense, thereby lowering the threshold for ferroptosis in cardiovascular and renal tissues. This process may amplify hemodynamic stress, impair endothelial integrity, and disturb renal sodium handling, ultimately contributing to the development and progression of hypertension. Although direct causal evidence remains limited, this review integrates circadian biology with ferroptosis and provides a mechanistic link between time-dependent physiological regulation and structural organ damage, highlighting a potentially promising strategy for future hypertension intervention.
SN - 2297-055X
ER -