Skip to content
DraconiticResearch
Search Sources API
220,788 studies31 sourcesUpdated 55 min ago
Peer-reviewedCC BYJournal of biophotonics

Noninvasive Intracranial Compliance Monitoring Following Hand-Applied Photobiomodulation and Ultrasound in Fibromyalgia: A Pilot Study.

  • Matheus Henrique Camargo Antonio1,2,3
  • Tiago Zuccolotto Rodrigues2,3
  • Ana Carolina Negraes Canelada1,2,3
  • Fernanda Mansano Carbinatto1,2
  • Vanessa Garcia2,3
  • Vanderlei Salvador Bagnato2,3,4
  • Antonio Eduardo de Aquino Junior1,2
4 affiliations
  1. 1Instituto de Ensino e Pesquisa (IEP), Irmandade da Santa Casa de Misericórdia de São Carlos, São Carlos, São Paulo, Brazil.
  2. 2Physics Institute of São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil.
  3. 3Pos-Graduation Program of Biotechnology, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  4. 4Department of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Read full textPDFDOICite

Abstract

Fibromyalgia (FM) is associated with chronic pain and altered neurophysiological regulation. This exploratory pilot study examined intracranial pulse waveform parameters and clinical outcomes following combined photobiomodulation therapy (PBMT) and therapeutic ultrasound (TUS) applied bilaterally to the hands. Twenty women participated (FM, n = 10; healthy comparators, n = 10); both groups received 10 sessions over 5 weeks. Noninvasive measurements included waveform morphology, P2/P1 ratio, and time to peak. Pain intensity, Fibromyalgia Impact Questionnaire, and Pittsburgh Sleep Quality Index scores were also assessed. At baseline, participants with FM showed a higher proportion of P2 > P1 waveforms and longer time to peak than healthy participants. Following treatment, the FM group showed fewer P2 > P1 waveforms, shorter time to peak, and lower pain, functional impact, and sleep disturbance scores. The P2/P1 ratio did not change significantly. Without a sham-treated group, these findings indicate preliminary associations rather than treatment efficacy or causality.

Related

  1. Intraoperative intra-aneurysmal pressure monitoring to individualize flow diverter therapy and optimize coil use in unruptured intracranial aneurysms
    Jianguo Zhong, Renhui Yi, Yu Jiang +3
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textNeurologyCrossref
  2. Intracranial pulsatile pressure gradient: a hypothesis and the potential role of dual intracranial pressure monitoring
    Georgios Tsermoulas
    Frontiers in SurgeryPeer-reviewedCC BY 4.0Full textNeurologyPMC
  3. Continuous intra-arterial versus noninvasive blood pressure monitoring for preventing hypotension during anesthesia induction in patients aged ≥ 75 years undergoing noncardiac surgery: a randomized controlled trial.
    Yihang Li, Shuang Liang, Yuqi Zhang +3
    BMC anesthesiologyPeer-reviewedCC BY-NC-NDFull textSurgery & anaesthesiaEurope PMCDOAJ
  4. Limited utility of optic nerve sheath diameter for monitoring intracranial pressure in patients with intracranial hemorrhage
    Beschan Ahmad, Mario Maria Joachim Trappe, Lars-Olav Harnisch +4
    Frontiers in neurologyPeer-reviewedCC BYFull textNeurologyEurope PMCCrossref
  5. Real-World Evaluation of a Near-Infrared Spectroscopy–based Noninvasive Glucose Monitoring Device in Adults With Type 2 Diabetes
    Sandra Amuedo, Mónica Enríquez Macías, José Manuel Fornés +8
    Journal of Diabetes Science and TechnologyPeer-reviewedCC BY 4.0Full textEndocrinology & metabolismPMCEurope PMC

Cite

BibTeXRIS
BibTeX
@article{antonio2026noninvasive,
  title = {{Noninvasive Intracranial Compliance Monitoring Following Hand-Applied Photobiomodulation and Ultrasound in Fibromyalgia: A Pilot Study.}},
  author = {Matheus Henrique Camargo Antonio and Tiago Zuccolotto Rodrigues and Ana Carolina Negraes Canelada and Fernanda Mansano Carbinatto and Vanessa Garcia and Vanderlei Salvador Bagnato and Antonio Eduardo de Aquino Junior},
  journal = {Journal of biophotonics},
  year = {2026},
  month = nov,
  doi = {10.1002/jbio.70390},
  url = {https://europepmc.org/article/MED/43008713},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Noninvasive Intracranial Compliance Monitoring Following Hand-Applied Photobiomodulation and Ultrasound in Fibromyalgia: A Pilot Study.
AU  - Matheus Henrique Camargo Antonio
AU  - Tiago Zuccolotto Rodrigues
AU  - Ana Carolina Negraes Canelada
AU  - Fernanda Mansano Carbinatto
AU  - Vanessa Garcia
AU  - Vanderlei Salvador Bagnato
AU  - Antonio Eduardo de Aquino Junior
PY  - 2026
DA  - 2026/11/01
JO  - Journal of biophotonics
DO  - 10.1002/jbio.70390
UR  - https://europepmc.org/article/MED/43008713
AB  - Fibromyalgia (FM) is associated with chronic pain and altered neurophysiological regulation. This exploratory pilot study examined intracranial pulse waveform parameters and clinical outcomes following combined photobiomodulation therapy (PBMT) and therapeutic ultrasound (TUS) applied bilaterally to the hands. Twenty women participated (FM, n = 10; healthy comparators, n = 10); both groups received 10 sessions over 5 weeks. Noninvasive measurements included waveform morphology, P2/P1 ratio, and time to peak. Pain intensity, Fibromyalgia Impact Questionnaire, and Pittsburgh Sleep Quality Index scores were also assessed. At baseline, participants with FM showed a higher proportion of P2 > P1 waveforms and longer time to peak than healthy participants. Following treatment, the FM group showed fewer P2 > P1 waveforms, shorter time to peak, and lower pain, functional impact, and sleep disturbance scores. The P2/P1 ratio did not change significantly. Without a sham-treated group, these findings indicate preliminary associations rather than treatment efficacy or causality.
SN  - 1864-063X
SN  - 1864-0648
ER  -