Case Report: Successful treatment of verruciform acanthotic vulvar intraepithelial neoplasia with 5-aminolevulinic acid photodynamic therapy.
- 1Department of Dermatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, and Shanghai Institute of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, China.
Abstract
Verruciform acanthotic vulvar intraepithelial neoplasia (vaVIN) is a rare, human papillomavirus (HPV)-independent, p53 wild-type intraepithelial precursor of the vulva, and standardized therapies for this disease are currently lacking. We report the case of a 68-year-old woman who presented with a 2-year history of multiple warty papules and vulvar pruritus and was diagnosed with vaVIN on the basis of histopathology (verruciform acanthosis with compact orthokeratosis, hypogranulosis, and superficial keratinocyte pallor with minimal cytologic atypia) and immunohistochemistry (HPV negativity, a p53 wild-type pattern, and non-block p16 expression) analyses. She underwent 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and achieved complete clinical remission, with no recurrence during the follow-up period. To our knowledge, reports on the use of photodynamic therapy for vaVIN are scarce. This case suggests that ALA-PDT may be a promising alternative treatment option for vaVIN.
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BibTeX
@article{qian2026case,
title = {{Case Report: Successful treatment of verruciform acanthotic vulvar intraepithelial neoplasia with 5-aminolevulinic acid photodynamic therapy.}},
author = {Yitao Qian and Wenjing Zha and Jie Shen and Ke Li and Szeman Cheung and Yiwu Yu and Jianhua Huang and Ting Lyu and Fei Miao and Hongwei Wang and Lei Shi},
journal = {Frontiers in medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1949400},
url = {https://europepmc.org/article/MED/42908848},
note = {CC BY},
}
RIS
TY - JOUR
TI - Case Report: Successful treatment of verruciform acanthotic vulvar intraepithelial neoplasia with 5-aminolevulinic acid photodynamic therapy.
AU - Yitao Qian
AU - Wenjing Zha
AU - Jie Shen
AU - Ke Li
AU - Szeman Cheung
AU - Yiwu Yu
AU - Jianhua Huang
AU - Ting Lyu
AU - Fei Miao
AU - Hongwei Wang
AU - Lei Shi
PY - 2026
DA - 2026/10/07
JO - Frontiers in medicine
DO - 10.3389/fmed.2026.1949400
UR - https://europepmc.org/article/MED/42908848
AB - Verruciform acanthotic vulvar intraepithelial neoplasia (vaVIN) is a rare, human papillomavirus (HPV)-independent, p53 wild-type intraepithelial precursor of the vulva, and standardized therapies for this disease are currently lacking. We report the case of a 68-year-old woman who presented with a 2-year history of multiple warty papules and vulvar pruritus and was diagnosed with vaVIN on the basis of histopathology (verruciform acanthosis with compact orthokeratosis, hypogranulosis, and superficial keratinocyte pallor with minimal cytologic atypia) and immunohistochemistry (HPV negativity, a p53 wild-type pattern, and non-block p16 expression) analyses. She underwent 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and achieved complete clinical remission, with no recurrence during the follow-up period. To our knowledge, reports on the use of photodynamic therapy for vaVIN are scarce. This case suggests that ALA-PDT may be a promising alternative treatment option for vaVIN.
SN - 2296-858X
ER -