Impact of Proportional Assist Ventilation Versus Pressure Support Ventilation on Adult Liberation From Mechanical Ventilation: A Revised Systematic Review and Meta-Analysis of RCTs.
6 affiliations
- 1Department of Medicine Nishtar Medical University Multan Pakistan duhs.edu.pk.
- 2Department of Medicine Services Institute of Medical Sciences Lahore Pakistan sims.edu.pk.
- 3Department of Medicine King Edward Medical University Lahore Pakistan kemu.edu.pk.
- 4Mayo Clinic Rochester Minnesota USA mayo.edu.
- 5Department of Medicine MGM Medical College Navi Mumbai India mgmmedicalcollege.org.
- 6Department of Medicine Kist Medical College Lalitpur Nepal kistmcth.edu.np.
Abstract
Background
Pressure assist ventilation (PAV) is considered superior to pressure support ventilation (PSV). We performed an updated systematic review and meta-analysis to evaluate comparative effectiveness in terms of weaning outcomes.Methods
We searched PubMed, Embase, and Cochrane for eligible randomized controlled trials (RCTs) published before October 2025 that directly compared clinical outcomes of PAV and PSV in mechanically ventilated adults. R program was used to calculate risk ratio (RR) and mean difference (MD) with 95% confidence intervals (CIs).Results
After screening the titles, abstracts, and full texts, we included eight RCTs consisting of 1057 patients in our systematic review and meta-analysis. PAV was associated with a higher rate of weaning success as compared to PSV (RR: 1.09; 95% CI, 1.01-1.18; p = 0.03; I ² = 23%). PAV was associated with a lesser duration of ventilation (MD: -1.06; 95% CI, -1.82 to -0.29, p = 0.006; I ² = 0%) and intensive care unit (ICU) stay (MD: -1.49; 95% CI: -2.43 to -0.54, p = 0.002; I ² = 25%) as compared to PSV. However, no statistically significant benefit was observed for PAV over PSV with regard to rate of reintubation (RR: 0.82; 95%, CI: 0.58-1.16, p = 0.21, I ² = 0%) and mortality (RR: 0.89; 95% CI: 0.63-1.25 p = 0.4I ² = 30%).Conclusion
PAV is superior to PSV for weaning, showing increased success and shorter duration of ventilation and ICU stays, though reintubation and mortality rates were similar.
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BibTeX
@article{raza2026impact,
title = {{Impact of Proportional Assist Ventilation Versus Pressure Support Ventilation on Adult Liberation From Mechanical Ventilation: A Revised Systematic Review and Meta-Analysis of RCTs.}},
author = {Muhammad Hassan Raza and Obaid Ur Rehman and Umad Ali and Aqsa Komel and Pratishruti and Talha Bin Kashif and Ajay Pandey},
journal = {Critical care research and practice},
year = {2026},
month = oct,
doi = {10.1155/ccrp/7536067},
url = {https://europepmc.org/article/MED/42959802},
note = {CC BY},
}
RIS
TY - JOUR
TI - Impact of Proportional Assist Ventilation Versus Pressure Support Ventilation on Adult Liberation From Mechanical Ventilation: A Revised Systematic Review and Meta-Analysis of RCTs.
AU - Muhammad Hassan Raza
AU - Obaid Ur Rehman
AU - Umad Ali
AU - Aqsa Komel
AU - Pratishruti
AU - Talha Bin Kashif
AU - Ajay Pandey
PY - 2026
DA - 2026/10/29
JO - Critical care research and practice
DO - 10.1155/ccrp/7536067
UR - https://europepmc.org/article/MED/42959802
AB - Background Pressure assist ventilation (PAV) is considered superior to pressure support ventilation (PSV). We performed an updated systematic review and meta-analysis to evaluate comparative effectiveness in terms of weaning outcomes.Methods We searched PubMed, Embase, and Cochrane for eligible randomized controlled trials (RCTs) published before October 2025 that directly compared clinical outcomes of PAV and PSV in mechanically ventilated adults. R program was used to calculate risk ratio (RR) and mean difference (MD) with 95% confidence intervals (CIs).Results After screening the titles, abstracts, and full texts, we included eight RCTs consisting of 1057 patients in our systematic review and meta-analysis. PAV was associated with a higher rate of weaning success as compared to PSV (RR: 1.09; 95% CI, 1.01-1.18; p = 0.03; I ² = 23%). PAV was associated with a lesser duration of ventilation (MD: -1.06; 95% CI, -1.82 to -0.29, p = 0.006; I ² = 0%) and intensive care unit (ICU) stay (MD: -1.49; 95% CI: -2.43 to -0.54, p = 0.002; I ² = 25%) as compared to PSV. However, no statistically significant benefit was observed for PAV over PSV with regard to rate of reintubation (RR: 0.82; 95%, CI: 0.58-1.16, p = 0.21, I ² = 0%) and mortality (RR: 0.89; 95% CI: 0.63-1.25 p = 0.4I ² = 30%).Conclusion PAV is superior to PSV for weaning, showing increased success and shorter duration of ventilation and ICU stays, though reintubation and mortality rates were similar.
SN - 2090-1305
SN - 2090-1313
ER -