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Peer-reviewedCC BYGenome biology

A complete reference genome reveals genetic landscape of Brassica centromeres.

  • Xin-Dong Xu1,2,3
  • Si-Ying Ye1
  • Pei Wu1
  • Yong-Qing Qian1
  • Zu-Wen Zhou1,3
  • Yibo Chai1
  • Ziyan Feng1
  • Yingying Tan1
  • Jie Xiang1,4
  • Lijuan Wei1,4
  • Rui Wang1,4
  • Qingyuan Zhou1,4
5 more authors
  • Cunmin Qu1,4
  • Jiana Li1
  • Ling-Ling Chen5,6
  • Kun Lu7,8
  • Jia-Ming Song9,10,11
11 affiliations
  1. 1College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China.
  2. 2Yazhouwan National Laboratory, Sanya, 572025, China.
  3. 3College of Life Science and Technology, Guangxi University, Nanning, 530004, China.
  4. 4Engineering Research Center of Grain and Oil Crops in Southwest Mountain, Ministry of Education, Chongqing, China.
  5. 5Yazhouwan National Laboratory, Sanya, 572025, China. [email protected].
  6. 6College of Life Science and Technology, Guangxi University, Nanning, 530004, China. [email protected].
  7. 7College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China. [email protected].
  8. 8Engineering Research Center of Grain and Oil Crops in Southwest Mountain, Ministry of Education, Chongqing, China. [email protected].
  9. 9College of Agronomy and Biotechnology, Southwest University, Chongqing, 400715, China. [email protected].
  10. 10Engineering Research Center of Grain and Oil Crops in Southwest Mountain, Ministry of Education, Chongqing, China. [email protected].
  11. 11Key Laboratory of Germplasm Innovation of Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Southwest University, Chongqing, 400715, China. [email protected].
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Abstract

Centromeres are essential for chromosome segregation, yet their organization and evolution remain poorly understood in polyploid crops. We present the first complete telomere-to-telomere reference genome of Brassica napus cultivar Zhongshuang11 and characterize centromere architecture and evolution. We identify core satellite repeats that define centromeres and reveal extensive sequence polymorphism and structural divergence between subgenomes associated with polyploidization and domestication. We further uncover rDNA-enriched pericentromeres generated by recurrent chromosome rearrangements and propose a centromere evolutionary cycle model that explains how satellite repeats and transposons jointly shape centromere evolution.

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Cite

BibTeXRIS
BibTeX
@article{xu2026complete,
  title = {{A complete reference genome reveals genetic landscape of Brassica centromeres.}},
  author = {Xin-Dong Xu and Si-Ying Ye and Pei Wu and Yong-Qing Qian and Zu-Wen Zhou and Yibo Chai and Ziyan Feng and Yingying Tan and Jie Xiang and Lijuan Wei and Rui Wang and Qingyuan Zhou and Cunmin Qu and Jiana Li and Ling-Ling Chen and Kun Lu and Jia-Ming Song},
  journal = {Genome biology},
  year = {2026},
  month = jul,
  doi = {10.1186/s13059-026-04218-4},
  url = {https://europepmc.org/article/MED/42958420},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A complete reference genome reveals genetic landscape of Brassica centromeres.
AU  - Xin-Dong Xu
AU  - Si-Ying Ye
AU  - Pei Wu
AU  - Yong-Qing Qian
AU  - Zu-Wen Zhou
AU  - Yibo Chai
AU  - Ziyan Feng
AU  - Yingying Tan
AU  - Jie Xiang
AU  - Lijuan Wei
AU  - Rui Wang
AU  - Qingyuan Zhou
AU  - Cunmin Qu
AU  - Jiana Li
AU  - Ling-Ling Chen
AU  - Kun Lu
AU  - Jia-Ming Song
PY  - 2026
DA  - 2026/07/27
JO  - Genome biology
DO  - 10.1186/s13059-026-04218-4
UR  - https://europepmc.org/article/MED/42958420
AB  - Centromeres are essential for chromosome segregation, yet their organization and evolution remain poorly understood in polyploid crops. We present the first complete telomere-to-telomere reference genome of Brassica napus cultivar Zhongshuang11 and characterize centromere architecture and evolution. We identify core satellite repeats that define centromeres and reveal extensive sequence polymorphism and structural divergence between subgenomes associated with polyploidization and domestication. We further uncover rDNA-enriched pericentromeres generated by recurrent chromosome rearrangements and propose a centromere evolutionary cycle model that explains how satellite repeats and transposons jointly shape centromere evolution.
SN  - 1474-7596
SN  - 1474-760X
ER  -