[Diagnosis and Intraoperative Decision-making in Pulmonary Sclerosing Pneumocytoma with Atypical Imaging Findings: A Case Report and Review of the Literature].
- 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
- 2School of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Abstract
Pulmonary sclerosing pneumocytoma (PSP) is a rare benign pulmonary tumor that predominantly occurs in middle-aged women. Its preoperative diagnosis remains challenging, and it is frequently misdiagnosed as a malignant tumor. Herein, we report a case of PSP with atypical imaging manifestations and review the current literature on this entity. A 68-year-old woman presented with chest tightness. Chest computed tomography (CT) revealed a lobulated solid nodule in the right middle lobe measuring approximately 26 mm × 22 mm, accompanied by multiple enlarged lymph nodes in the bilateral hilar, mediastinal, and axillary regions. The diagnosis of PSP was confirmed by postoperative histopathology. Based on the features of this case and review of the relevant literature, we suggest that when a patient presents with clinical features suggestive of PSP and intraoperative frozen-section hematoxylin and eosin staining predominantly shows a single solid or papillary architecture in which the surface and stromal cells are difficult to distinguish, intraoperative rapid immunohistochemistry may be performed to improve diagnostic accuracy and avoid excessive surgical resection. .
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BibTeX
@article{xu2026diagnosis,
title = {{[Diagnosis and Intraoperative Decision-making in Pulmonary Sclerosing Pneumocytoma with Atypical Imaging Findings: A Case Report and Review of the Literature].}},
author = {Xingyi Xu and Hui Xiao and Xiong Ye},
journal = {Zhongguo fei ai za zhi = Chinese journal of lung cancer},
year = {2026},
month = aug,
doi = {10.3779/j.issn.1009-3419.2026.101.22},
url = {https://europepmc.org/article/MED/42896978},
note = {CC BY},
}
RIS
TY - JOUR
TI - [Diagnosis and Intraoperative Decision-making in Pulmonary Sclerosing Pneumocytoma with Atypical Imaging Findings: A Case Report and Review of the Literature].
AU - Xingyi Xu
AU - Hui Xiao
AU - Xiong Ye
PY - 2026
DA - 2026/08/01
JO - Zhongguo fei ai za zhi = Chinese journal of lung cancer
DO - 10.3779/j.issn.1009-3419.2026.101.22
UR - https://europepmc.org/article/MED/42896978
AB - Pulmonary sclerosing pneumocytoma (PSP) is a rare benign pulmonary tumor that predominantly occurs in middle-aged women. Its preoperative diagnosis remains challenging, and it is frequently misdiagnosed as a malignant tumor. Herein, we report a case of PSP with atypical imaging manifestations and review the current literature on this entity. A 68-year-old woman presented with chest tightness. Chest computed tomography (CT) revealed a lobulated solid nodule in the right middle lobe measuring approximately 26 mm × 22 mm, accompanied by multiple enlarged lymph nodes in the bilateral hilar, mediastinal, and axillary regions. The diagnosis of PSP was confirmed by postoperative histopathology. Based on the features of this case and review of the relevant literature, we suggest that when a patient presents with clinical features suggestive of PSP and intraoperative frozen-section hematoxylin and eosin staining predominantly shows a single solid or papillary architecture in which the surface and stromal cells are difficult to distinguish, intraoperative rapid immunohistochemistry may be performed to improve diagnostic accuracy and avoid excessive surgical resection. .
SN - 1009-3419
SN - 1999-6187
ER -