Pathogenic autoantibodies targeting DNA repair proteins are shared by cancer patients and healthy children later diagnosed with cancer
6 affiliations
- 1Department of Clinical Science, University of Bergen
- 2Department of Global Public Health and Primary Care, University of Bergen
- 3The Norwegian Childhood Cancer Biobank, The Department of Pediatric Oncology and Hematology, Oslo University Hospital
- 4Department of Oncology, Oslo University Hospital
- 5Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital
- 6Western Norway Familial Cancer Center, Haukeland University Hospital
Abstract
The etiology of pediatric cancer remains poorly understood and does not fit the classical view as an age-associated genetic disease, suggesting yet unknown mechanisms might be involved. Using high-density native proteome arrays, we analyzed sera from 375 healthy individuals and patients. We found a significant enrichment of autoantibodies against DNA repair proteins shared by cancer patients and healthy children diagnosed with cancer years later. These autoantibodies were detected in multiple cancer types and exhibited remarkable age-specificity. To explore their potential pathogenic significance, we assessed the ability of serum IgG to penetrate live cells. We confirmed that IgG can indeed enter live intact cells and identified a specific pattern of subcellular localization prevalent in pediatric patients. These findings offer a novel direction for the investigation of etiology of pediatric cancer and cancer in general.
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BibTeX
@article{serguienko2026pathogenic,
title = {{Pathogenic autoantibodies targeting DNA repair proteins are shared by cancer patients and healthy children later diagnosed with cancer}},
author = {Anastassia Serguienko and Jeetesh Sharma and Ronas Shakya and Monica Cheng Munthe-Kaas and Kjetil Boye and Ola Myklebost},
journal = {Frontiers in Immunology},
year = {2026},
month = oct,
doi = {10.3389/fimmu.2026.1911932},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1911932/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Pathogenic autoantibodies targeting DNA repair proteins are shared by cancer patients and healthy children later diagnosed with cancer
AU - Anastassia Serguienko
AU - Jeetesh Sharma
AU - Ronas Shakya
AU - Monica Cheng Munthe-Kaas
AU - Kjetil Boye
AU - Ola Myklebost
PY - 2026
DA - 2026/10/14
JO - Frontiers in Immunology
DO - 10.3389/fimmu.2026.1911932
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1911932/full
AB - The etiology of pediatric cancer remains poorly understood and does not fit the classical view as an age-associated genetic disease, suggesting yet unknown mechanisms might be involved. Using high-density native proteome arrays, we analyzed sera from 375 healthy individuals and patients. We found a significant enrichment of autoantibodies against DNA repair proteins shared by cancer patients and healthy children diagnosed with cancer years later. These autoantibodies were detected in multiple cancer types and exhibited remarkable age-specificity. To explore their potential pathogenic significance, we assessed the ability of serum IgG to penetrate live cells. We confirmed that IgG can indeed enter live intact cells and identified a specific pattern of subcellular localization prevalent in pediatric patients. These findings offer a novel direction for the investigation of etiology of pediatric cancer and cancer in general.
SN - 1664-3224
ER -