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Peer-reviewedCC BY 4.0Nutrients

Novel Allulose- and Amino Acid-Containing Sugar-Free Electrolyte Beverage Improves Body Water Restoration in Ad Libitum Rehydration Following Exercise-Induced Dehydration

  • Sajjad Rezaei1
  • Sai Tejaswari Gopalakrishnan1
  • Parker Kooima2
  • Abigail E. Wasserbeck1
  • Isabela E. Kavoura1
  • Oviya Srikanth1
  • Vivian Cervantes1
  • Ryan J. Muro1
  • Michael Lelko3
  • Floris C. Wardenaar2
  • Gwyneth W. Gordon4
  • Stavros A. Kavouras1
4 affiliations
  1. 1Hydration Science Lab, College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA
  2. 2Athleat Field Lab, College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA
  3. 3Liquid I.V., El Segundo, CA 90245, USA
  4. 4The Metals, Environmental and Terrestrial Analytical Laboratory (METAL), Arizona State University, Tempe, AZ 85287, USA
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Abstract

Objectives: This study evaluated the rehydration efficacy of a novel sugar-free oral rehydration solution sweetened with allulose and amino acids (SF-ORS), compared to a traditional sugar-sweetened ORS (SS-ORS) and water. Methods: Twenty recreationally active adults (nine females) participated in a randomized crossover study involving three rehydration trials after a ~1.8% body mass loss induced by exercise in heat. Participants consumed ad libitum for 4 h one of: (a) SS-ORS (glucose/sucrose: 26 g/L, Na+: 49 mmol/L, K+: 19 mmol/L, osmolality: 223 mmol/kg); (b) SF-ORS (allulose: ~8 g/L, L-glutamine and L-alanine: ~8 g/L, Na+: 46 mmol/L, K+: 19 mmol/L, osmolality: 234 mmol/kg); or (c) plain water, all labeled with D2O (10 g/L) to trace the appearance of ingested fluid in plasma. Results: There was no statistically significant difference in total fluid intake between trials (water: 1603 ± 567, SF-ORS: 1826 ± 728, SS-ORS: 1918 ± 713 mL; p = 0.087). At 4 h, fluid retention following SF-ORS (46.6 ± 23.1%) and SS-ORS (39.7 ± 24.0%) was higher than water (24.8 ± 29.3%, all p < 0.05), and body weight was better restored following SF-ORS (0.83 ± 0.65%) than water (0.16 ± 0.77%, p = 0.011). Urine output at 3 h was lower following SF-ORS (753 ± 394 mL) than SS-ORS (976 ± 583 mL, p = 0.035). No significant difference in plasma D2O enrichment per gram of D2O ingested (average over 4 h) was found between SF-ORS (21.0 ± 5.5 ppm/g) and water (22.0 ± 5.0 ppm/g, p = 0.30), while SS-ORS (20.2 ± 4.9 ppm/g) showed lower enrichment per g ingested compared to water (p = 0.022). SF-ORS resulted in lower free water clearance than water over the rehydration period (p < 0.001). Conclusions: An allulose-sweetened, amino acid-based electrolyte beverage may be a viable option for post-exercise rehydration when limiting sugar and energy intake is desired.

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Cite

BibTeXRIS
BibTeX
@article{rezaei2026novel,
  title = {{Novel Allulose- and Amino Acid-Containing Sugar-Free Electrolyte Beverage Improves Body Water Restoration in Ad Libitum Rehydration Following Exercise-Induced Dehydration}},
  author = {Sajjad Rezaei and Sai Tejaswari Gopalakrishnan and Parker Kooima and Abigail E. Wasserbeck and Isabela E. Kavoura and Oviya Srikanth and Vivian Cervantes and Ryan J. Muro and Michael Lelko and Floris C. Wardenaar and Gwyneth W. Gordon and Stavros A. Kavouras},
  journal = {Nutrients},
  year = {2026},
  month = oct,
  doi = {10.3390/nu18213601},
  url = {https://www.mdpi.com/2072-6643/18/21/3601},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Novel Allulose- and Amino Acid-Containing Sugar-Free Electrolyte Beverage Improves Body Water Restoration in Ad Libitum Rehydration Following Exercise-Induced Dehydration
AU  - Sajjad Rezaei
AU  - Sai Tejaswari Gopalakrishnan
AU  - Parker Kooima
AU  - Abigail E. Wasserbeck
AU  - Isabela E. Kavoura
AU  - Oviya Srikanth
AU  - Vivian Cervantes
AU  - Ryan J. Muro
AU  - Michael Lelko
AU  - Floris C. Wardenaar
AU  - Gwyneth W. Gordon
AU  - Stavros A. Kavouras
PY  - 2026
DA  - 2026/10/30
JO  - Nutrients
DO  - 10.3390/nu18213601
UR  - https://www.mdpi.com/2072-6643/18/21/3601
AB  - Objectives: This study evaluated the rehydration efficacy of a novel sugar-free oral rehydration solution sweetened with allulose and amino acids (SF-ORS), compared to a traditional sugar-sweetened ORS (SS-ORS) and water. Methods: Twenty recreationally active adults (nine females) participated in a randomized crossover study involving three rehydration trials after a ~1.8% body mass loss induced by exercise in heat. Participants consumed ad libitum for 4 h one of: (a) SS-ORS (glucose/sucrose: 26 g/L, Na+: 49 mmol/L, K+: 19 mmol/L, osmolality: 223 mmol/kg); (b) SF-ORS (allulose: ~8 g/L, L-glutamine and L-alanine: ~8 g/L, Na+: 46 mmol/L, K+: 19 mmol/L, osmolality: 234 mmol/kg); or (c) plain water, all labeled with D2O (10 g/L) to trace the appearance of ingested fluid in plasma. Results: There was no statistically significant difference in total fluid intake between trials (water: 1603 ± 567, SF-ORS: 1826 ± 728, SS-ORS: 1918 ± 713 mL; p = 0.087). At 4 h, fluid retention following SF-ORS (46.6 ± 23.1%) and SS-ORS (39.7 ± 24.0%) was higher than water (24.8 ± 29.3%, all p < 0.05), and body weight was better restored following SF-ORS (0.83 ± 0.65%) than water (0.16 ± 0.77%, p = 0.011). Urine output at 3 h was lower following SF-ORS (753 ± 394 mL) than SS-ORS (976 ± 583 mL, p = 0.035). No significant difference in plasma D2O enrichment per gram of D2O ingested (average over 4 h) was found between SF-ORS (21.0 ± 5.5 ppm/g) and water (22.0 ± 5.0 ppm/g, p = 0.30), while SS-ORS (20.2 ± 4.9 ppm/g) showed lower enrichment per g ingested compared to water (p = 0.022). SF-ORS resulted in lower free water clearance than water over the rehydration period (p < 0.001). Conclusions: An allulose-sweetened, amino acid-based electrolyte beverage may be a viable option for post-exercise rehydration when limiting sugar and energy intake is desired.
SN  - 2072-6643
ER  -