Comparative outcomes of PreserFloTMMicroShunt in primary open-angle and pseudoexfoliative glaucoma: A matched analysis
- 1Department of Ophthalmology, University of Bonn, Bonn, Germany
- 2Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
- 3Department of Ophthalmology, Klinikum Dortmund, University Witten/Herdecke, Dortmund, Germany
Abstract
Purpose: Comparing outcomes of PreserFloTM MicroShunt in eyes with primary open-angle (POAG) and pseudoexfoliative glaucoma (PEXG) through a matched analysis. Methods: Retrospective matched-pair analysis of patients undergoing PreserFloTM MicroShunt (PFMS) due to POAG (n = 25) and PEXG (n = 25). Success rates (A/B: IOP ≤ 21 / 18 mmHg + IOP reduction ≥20% from baseline; C: IOP ≤ 15 mmHg + IOP reduction ≥25%; D: IOP ≤ 12 mmHg + IOP reduction ≥30%) and secondary outcomes were evaluated. Results: Fifty eyes of 49 patients were included. At 12 months, complete and qualified success rates for Criteria A – D were 68.0% and 96.0%, 68.0% and 96.0%, 64.0% and 72.0%, and 32.0% and 32.0%, respectively, in the POAG group, compared with 44.0% and 76.0%, 40.0% and 72.0%, 32.0% and 52.0%, and 8.0% and 12.0%, respectively, in the PEXG group (p = 0.039, 0.024, 0.189, and 0.271, respectively). Mean preoperative IOP decreased from 25.12 mmHg (POAG) and 25.64 mmHg (PEXG, p = 0.98) to 12.64 mmHg and 15.04 mmHg postoperatively (p = 0.043). The mean number of IOP-lowering drops was significantly lower in eyes with POAG (0.52 ± 1.01) than with PEXG (1.3 ± 1.55; p = 0.031) after 12 months. Eyes with PEXG had significantly higher rates of postoperative complications than eyes with POAG (p = 0.038) with no vision-threatening sequelae. Conclusions: PFMS is a safe and effective procedure for reducing IOP in eyes with POAG and PEXG, with lower IOP levels being achieved in eyes with POAG. Significantly more postoperative complications and interventions were needed in eyes with PEXG.
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BibTeX
@article{bourauel2026comparative,
title = {{Comparative outcomes of PreserFloTMMicroShunt in primary open-angle and pseudoexfoliative glaucoma: A matched analysis}},
author = {Leonie Bourauel and Benjamin Aretz and Michael Petrak and Frank G. Holz and Karl Mercieca and Constance Liegl},
journal = {PLOS One},
year = {2026},
month = sep,
doi = {10.1371/journal.pone.0357501},
url = {https://doi.org/10.1371/journal.pone.0357501},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Comparative outcomes of PreserFloTMMicroShunt in primary open-angle and pseudoexfoliative glaucoma: A matched analysis
AU - Leonie Bourauel
AU - Benjamin Aretz
AU - Michael Petrak
AU - Frank G. Holz
AU - Karl Mercieca
AU - Constance Liegl
PY - 2026
DA - 2026/09/02
JO - PLOS One
DO - 10.1371/journal.pone.0357501
UR - https://doi.org/10.1371/journal.pone.0357501
AB - Purpose: Comparing outcomes of PreserFloTM MicroShunt in eyes with primary open-angle (POAG) and pseudoexfoliative glaucoma (PEXG) through a matched analysis. Methods: Retrospective matched-pair analysis of patients undergoing PreserFloTM MicroShunt (PFMS) due to POAG (n = 25) and PEXG (n = 25). Success rates (A/B: IOP ≤ 21 / 18 mmHg + IOP reduction ≥20% from baseline; C: IOP ≤ 15 mmHg + IOP reduction ≥25%; D: IOP ≤ 12 mmHg + IOP reduction ≥30%) and secondary outcomes were evaluated. Results: Fifty eyes of 49 patients were included. At 12 months, complete and qualified success rates for Criteria A – D were 68.0% and 96.0%, 68.0% and 96.0%, 64.0% and 72.0%, and 32.0% and 32.0%, respectively, in the POAG group, compared with 44.0% and 76.0%, 40.0% and 72.0%, 32.0% and 52.0%, and 8.0% and 12.0%, respectively, in the PEXG group (p = 0.039, 0.024, 0.189, and 0.271, respectively). Mean preoperative IOP decreased from 25.12 mmHg (POAG) and 25.64 mmHg (PEXG, p = 0.98) to 12.64 mmHg and 15.04 mmHg postoperatively (p = 0.043). The mean number of IOP-lowering drops was significantly lower in eyes with POAG (0.52 ± 1.01) than with PEXG (1.3 ± 1.55; p = 0.031) after 12 months. Eyes with PEXG had significantly higher rates of postoperative complications than eyes with POAG (p = 0.038) with no vision-threatening sequelae. Conclusions: PFMS is a safe and effective procedure for reducing IOP in eyes with POAG and PEXG, with lower IOP levels being achieved in eyes with POAG. Significantly more postoperative complications and interventions were needed in eyes with PEXG.
SN - 1932-6203
ER -