Outcomes for Patients With Vestibular Schwannomas Treated With Gamma Knife Versus Linear Accelerator-Based Radiosurgery: A Retrospective Review.
- 1Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
- 2Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
- 3Department of Neurosurgery, Emory University, Atlanta, Georgia.
Abstract
Purpose
Prior studies have reported favorable local control for patients with vestibular schwannomas (VS) treated with Gamma Knife radiosurgery (GKRS) or linear accelerator (LINAC)-based radiosurgery; however, direct comparisons of quality-of-life outcomes with each approach are lacking. We assessed differences in quality-of-life outcomes and local control after radiation therapy for patients with VS treated with GKRS versus LINAC.Methods and materials
In this multicenter analysis, we retrospectively reviewed VS cases treated with either GKRS or LINAC and compared posttreatment clinical outcomes, including tumor control and new development of vertigo, gait disturbance, facial palsy, and tinnitus. Descriptive statistics were performed, and χ2 was used to assess intergroup differences. Univariate and multivariate analyses were performed to assess associations with the development of clinical outcomes.Results
Thirty-six patients treated with GKRS and 49 patients treated with LINAC were included in our analysis. All patients were treated with single-fraction radiosurgery. There was no statistically significant difference between LINAC and GKRS in the development of vertigo, gait disturbance, or facial palsy after treatment, and no clinically significant difference in the development of tinnitus. Local control was 98.8% across all patients, with no statistically significant difference in tumor control between groups.Conclusions
This analysis showed comparable rates of new vertigo, gait disturbance, tinnitus, and facial palsy with GKRS and LINAC-based radiosurgery for VS, supporting the interchangeability of these treatment approaches. Prospective data are needed to further compare these treatment approaches.
Related
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- Sudden hearing loss in enlarged vestibular aqueduct syndrome: a systematic review of treatment and outcomes
- Single-Session Versus Hypofractionated Gamma Knife Radiosurgery for Large Parasagittal Meningiomas: A Retrospective Comparative Study.
- Peripheral immune-inflammatory markers associated with intracranial progression-free survival after Gamma Knife radiosurgery in patients with non-small cell lung cancer brain metastases: a retrospective cohort study.
- Stereotactic Radiosurgery for Trigeminal Neuralgia: A Comparison of Proximal and Distal Isocenter Outcomes
BibTeX
@article{corriher2026outcomes,
title = {{Outcomes for Patients With Vestibular Schwannomas Treated With Gamma Knife Versus Linear Accelerator-Based Radiosurgery: A Retrospective Review.}},
author = {Taylor Corriher and Manali Rupji and Joshua Lorenz and Katherine Sykes-Martin and Christopher Deibert and Hui-Kuo Shu and Bree Eaton and Shannon Kahn and Jim Zhong},
journal = {Advances in radiation oncology},
year = {2026},
month = aug,
doi = {10.1016/j.adro.2026.102177},
url = {https://europepmc.org/article/MED/42927347},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Outcomes for Patients With Vestibular Schwannomas Treated With Gamma Knife Versus Linear Accelerator-Based Radiosurgery: A Retrospective Review.
AU - Taylor Corriher
AU - Manali Rupji
AU - Joshua Lorenz
AU - Katherine Sykes-Martin
AU - Christopher Deibert
AU - Hui-Kuo Shu
AU - Bree Eaton
AU - Shannon Kahn
AU - Jim Zhong
PY - 2026
DA - 2026/08/20
JO - Advances in radiation oncology
DO - 10.1016/j.adro.2026.102177
UR - https://europepmc.org/article/MED/42927347
AB - Purpose Prior studies have reported favorable local control for patients with vestibular schwannomas (VS) treated with Gamma Knife radiosurgery (GKRS) or linear accelerator (LINAC)-based radiosurgery; however, direct comparisons of quality-of-life outcomes with each approach are lacking. We assessed differences in quality-of-life outcomes and local control after radiation therapy for patients with VS treated with GKRS versus LINAC.Methods and materials In this multicenter analysis, we retrospectively reviewed VS cases treated with either GKRS or LINAC and compared posttreatment clinical outcomes, including tumor control and new development of vertigo, gait disturbance, facial palsy, and tinnitus. Descriptive statistics were performed, and χ2 was used to assess intergroup differences. Univariate and multivariate analyses were performed to assess associations with the development of clinical outcomes.Results Thirty-six patients treated with GKRS and 49 patients treated with LINAC were included in our analysis. All patients were treated with single-fraction radiosurgery. There was no statistically significant difference between LINAC and GKRS in the development of vertigo, gait disturbance, or facial palsy after treatment, and no clinically significant difference in the development of tinnitus. Local control was 98.8% across all patients, with no statistically significant difference in tumor control between groups.Conclusions This analysis showed comparable rates of new vertigo, gait disturbance, tinnitus, and facial palsy with GKRS and LINAC-based radiosurgery for VS, supporting the interchangeability of these treatment approaches. Prospective data are needed to further compare these treatment approaches.
SN - 2452-1094
ER -