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Peer-reviewedCC BY-NC-ND 4.0JACC Case Reports

Primary Cardiac Paraganglioma Management and Resection With Rare Recurrent Metastasis

  • Ashley B. Chuong1
  • Marcell Szekely2
  • Maria G. Lopez-Trevino2
  • Dale Hamilton3
  • Michael J. Reardon2
  • Marvin D. Atkins2
  1. 1Texas A&M School of Engineering Medicine, Houston, Texas, USA
  2. 2Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston, Texas, USA
  3. 3Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA
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Abstract

Background: Primary cardiac paragangliomas are rare tumors that present with nonspecific sympathomimetic symptoms. Early recognition and multidisciplinary planning are essential.

Case Summary: A 55-year-old man presented with atrial fibrillation and pericarditis after weeks of dizziness, presyncope, and dyspnea. The patient underwent biopsy via thoracotomy, which was negative for malignancy. Workup revealed a 10 × 12 × 5 cm functional paraganglioma with left atrial involvement. He underwent cardiac autotransplantation with complete tumor resection and left atrial reconstruction. Postoperative recovery was complicated by extracorporeal membrane oxygenation requirement and stroke. One year later, surveillance identified a T9 vertebral metastasis, confirmed on biopsy, and later treated with Belzutifan, radiation, and kyphoplasty.

Discussion: Cardiac paragangliomas often require complex surgical approaches. This case highlights diagnostic difficulty, metastatic potential, and evolving systemic therapies of interest to cardiovascular and oncology specialists.

Take-Home Messages: Cardiac paragangliomas demand multidisciplinary management and long-term surveillance. Newer targeted therapies expand options for metastatic disease.

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Cite

BibTeXRIS
BibTeX
@article{chuong2026primary,
  title = {{Primary Cardiac Paraganglioma Management and Resection With Rare Recurrent Metastasis}},
  author = {Ashley B. Chuong and Marcell Szekely and Maria G. Lopez-Trevino and Dale Hamilton and Michael J. Reardon and Marvin D. Atkins},
  journal = {JACC Case Reports},
  year = {2026},
  month = aug,
  doi = {10.1016/j.jaccas.2026.109928},
  url = {https://doi.org/10.1016/j.jaccas.2026.109928},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Primary Cardiac Paraganglioma Management and Resection With Rare Recurrent Metastasis
AU  - Ashley B. Chuong
AU  - Marcell Szekely
AU  - Maria G. Lopez-Trevino
AU  - Dale Hamilton
AU  - Michael J. Reardon
AU  - Marvin D. Atkins
PY  - 2026
DA  - 2026/08/20
JO  - JACC Case Reports
DO  - 10.1016/j.jaccas.2026.109928
UR  - https://doi.org/10.1016/j.jaccas.2026.109928
AB  - Background: Primary cardiac paragangliomas are rare tumors that present with nonspecific sympathomimetic symptoms. Early recognition and multidisciplinary planning are essential.  Case Summary: A 55-year-old man presented with atrial fibrillation and pericarditis after weeks of dizziness, presyncope, and dyspnea. The patient underwent biopsy via thoracotomy, which was negative for malignancy. Workup revealed a 10 × 12 × 5 cm functional paraganglioma with left atrial involvement. He underwent cardiac autotransplantation with complete tumor resection and left atrial reconstruction. Postoperative recovery was complicated by extracorporeal membrane oxygenation requirement and stroke. One year later, surveillance identified a T9 vertebral metastasis, confirmed on biopsy, and later treated with Belzutifan, radiation, and kyphoplasty.  Discussion: Cardiac paragangliomas often require complex surgical approaches. This case highlights diagnostic difficulty, metastatic potential, and evolving systemic therapies of interest to cardiovascular and oncology specialists.  Take-Home Messages: Cardiac paragangliomas demand multidisciplinary management and long-term surveillance. Newer targeted therapies expand options for metastatic disease.
SN  - 2666-0849
ER  -