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Peer-reviewedCC BY-NC-NDChemical & biomedical imaging

PET Imaging of Osteomyelitis with [⁶⁸Ga]Ga-BP.

  • Mukesh K Pandey1,2,3
  • Aditya Bansal1
  • Shalini Sharma1
  • Melissa Karau4
  • Yash S Raval4
  • Stephen M Broski1
  • Robin Patel4,5
  • Mark Nathan1
  • Val J Lowe1
5 affiliations
  1. 1Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, United States.
  2. 2Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota 55905, United States.
  3. 3Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, United States.
  4. 4Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota 55905, United States.
  5. 5Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, Minnesota 55905, United States.
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Abstract

A low-cost, easy-to-adopt noninvasive imaging modality for differentiating bacterial infection from inflammation is desirable to accurately diagnose bacterial infections. Herein, a bacteria-specific PET probe, [68Ga]-Ga-BP, was developed and evaluated in rat models of foreign body-associated osteomyelitis induced by methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae and was directly compared with sterile inflammation and uninstrumented uninfected controls. [68Ga]-Ga-BP-based imaging of MRSA-infected tibiae was also compared to [68Ga]-Ga-citrate and [18F]-FDG. After iron depletion, dynamic PET/CT imaging was performed at 15-120 min postinjection of radiotracers, followed by assessment of ex vivo biodistribution. [68Ga]-Ga-BP successfully detected tibial infection and demonstrated >6-fold higher uptake in infected tibiae with all three bacterial species versus contralateral tibiae via PET imaging. [68Ga]-Ga-BP outperformed [68Ga]-Ga-citrate and [18F]-FDG in identifying MRSA infection. [68Ga]-Ga-BP represents a promising, noninvasive PET imaging agent for direct bacterial detection and bacterial infection treatment monitoring.

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Cite

BibTeXRIS
BibTeX
@article{pandey2026imaging,
  title = {{PET Imaging of Osteomyelitis with [⁶⁸Ga]Ga-BP.}},
  author = {Mukesh K Pandey and Aditya Bansal and Shalini Sharma and Melissa Karau and Yash S Raval and Stephen M Broski and Robin Patel and Mark Nathan and Val J Lowe},
  journal = {Chemical \& biomedical imaging},
  year = {2026},
  month = jun,
  doi = {10.1021/cbmi.6c00082},
  url = {https://europepmc.org/article/MED/42953237},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - PET Imaging of Osteomyelitis with [⁶⁸Ga]Ga-BP.
AU  - Mukesh K Pandey
AU  - Aditya Bansal
AU  - Shalini Sharma
AU  - Melissa Karau
AU  - Yash S Raval
AU  - Stephen M Broski
AU  - Robin Patel
AU  - Mark Nathan
AU  - Val J Lowe
PY  - 2026
DA  - 2026/06/08
JO  - Chemical & biomedical imaging
DO  - 10.1021/cbmi.6c00082
UR  - https://europepmc.org/article/MED/42953237
AB  - A low-cost, easy-to-adopt noninvasive imaging modality for differentiating bacterial infection from inflammation is desirable to accurately diagnose bacterial infections. Herein, a bacteria-specific PET probe, [68Ga]-Ga-BP, was developed and evaluated in rat models of foreign body-associated osteomyelitis induced by methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae and was directly compared with sterile inflammation and uninstrumented uninfected controls. [68Ga]-Ga-BP-based imaging of MRSA-infected tibiae was also compared to [68Ga]-Ga-citrate and [18F]-FDG. After iron depletion, dynamic PET/CT imaging was performed at 15-120 min postinjection of radiotracers, followed by assessment of ex vivo biodistribution. [68Ga]-Ga-BP successfully detected tibial infection and demonstrated >6-fold higher uptake in infected tibiae with all three bacterial species versus contralateral tibiae via PET imaging. [68Ga]-Ga-BP outperformed [68Ga]-Ga-citrate and [18F]-FDG in identifying MRSA infection. [68Ga]-Ga-BP represents a promising, noninvasive PET imaging agent for direct bacterial detection and bacterial infection treatment monitoring.
SN  - 2832-3637
ER  -