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Peer-reviewedLicence not statedBMJ Open

CHOICE-UTI: protocol for a multicentre randomised non-inferiority trial comparing single versus three daily doses of intravenous antibiotics prior to oral therapy for complicated urinary tract infection in children

  • Laila F Ibrahim1,2,3,4
  • Francesca Orsini5,6
  • Amit Kochar7,8
  • Simon Craig9,10,11
  • Stuart Dalziel12,13,14
  • Sarah McNab2,3,15
  • Catherine Quinlan3,16,17
  • Amanda Williams18,19
  • Barry Scanlan1,3,20,21
  • Meredith L Borland22,23
  • Andrew Davidson3,6,10,24
  • Ariel Mace25,26
4 more authors
  • Scott Sypek8,27
  • Li Huang28
  • Franz E Babl3,18,19,29
  • Penelope A Bryant1,3,4,30
30 affiliations
  1. 1Clinical Infections, Murdoch Children’s Research Institute, Parkville, Victoria, Australia
  2. 2Department of General Medicine, Royal Children’s Hospital Melbourne, Parkville, Victoria, Australia
  3. 3Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia
  4. 4Hospital in the Home, The Royal Children’s Hospital Melbourne, Melbourne, Victoria, Australia
  5. 5Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, Parkville, Victoria, Australia
  6. 6Melbourne Children’s Trials Centre, Parkville, Victoria, Australia
  7. 7Paediatric Emergency, Women and Children’s Hospital Adelaide, Adelaide, South Australia, Australia
  8. 8Division of Acute Care Medicine, School of Medicine, College of Health, Adelaide University, Adelaide, South Australia, Australia
  9. 9Emergency Department, Monash Children's Hospital, Clayton, Victoria, Australia
  10. 10Clinical Sciences, Murdoch Children’s Research Institute, Parkville, Victoria, Australia
  11. 11Department of Paediatrics, Monash University, Melbourne, Victoria, Australia
  12. 12Department of Paediatrics, Child and Youth Health, The University of Auckland, Auckland, Auckland, New Zealand
  13. 13Department of Surgery, Child and Youth Health, The University of Auckland, Auckland, Auckland, New Zealand
  14. 14Children’s Emergency Department, Starship Children’s Health, Newmarket, Auckland, New Zealand
  15. 15Clinical Paediatrics, Murdoch Children’s Research Institute, Parkville, Victoria, Australia
  16. 16Kidney Regeneration, Murdoch Children's Research Institute, Parkville, Victoria, Australia
  17. 17Nephrology Department, Royal Children’s Hospital, Melbourne, Victoria, Australia
  18. 18Emergency Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia
  19. 19Emergency Department, The Royal Children’s Hospital Melbourne, Melbourne, Victoria, Australia
  20. 20General Paediatric Department, Children’s Health Ireland, Dublin, Leinster, Ireland
  21. 21School of Medicine, University College Dublin School of Medicine, Dublin, Leinster, Ireland
  22. 22Emergency Department, Perth Children’s Hospital, Nedlands, Western Australia, Australia
  23. 23Divisions of Paediatrics and Emergency Medicine, The University of Western Australia Medical School, Perth, Western Australia, Australia
  24. 24Department of Anaesthesia, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia
  25. 25Wesfarmers Centre of Vaccines and Infectious Diseases, The Kids Research Institute Australia, The University of Western Australia, Perth, Western Australia, Australia
  26. 26Department of General Paediatrics, Perth Children's Hospital, Nedlands, Western Australia, Australia
  27. 27Department of General Medicine, Women's and Children’s Hospital Adelaide, North Adelaide, South Australia, Australia
  28. 28Child Health Economics Unit, Centre for Health Policy, The University of Melbourne, Melbourne, Victoria, Australia
  29. 29Department of Critical Care, The University of Melbourne, Melbourne, Victoria, Australia
  30. 30Infectious Diseases, The Royal Children’s Hospital Melbourne, Melbourne, Victoria, Australia
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{ibrahim2026choiceuti,
  title = {{CHOICE-UTI: protocol for a multicentre randomised non-inferiority trial comparing single versus three daily doses of intravenous antibiotics prior to oral therapy for complicated urinary tract infection in children}},
  author = {Laila F Ibrahim and Francesca Orsini and Amit Kochar and Simon Craig and Stuart Dalziel and Sarah McNab and Catherine Quinlan and Amanda Williams and Barry Scanlan and Meredith L Borland and Andrew Davidson and Ariel Mace and Scott Sypek and Li Huang and Franz E Babl and Penelope A Bryant},
  journal = {BMJ Open},
  year = {2026},
  month = nov,
  doi = {10.1136/bmjopen-2026-119766},
  url = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-119766},
}
RIS
TY  - JOUR
TI  - CHOICE-UTI: protocol for a multicentre randomised non-inferiority trial comparing single versus three daily doses of intravenous antibiotics prior to oral therapy for complicated urinary tract infection in children
AU  - Laila F Ibrahim
AU  - Francesca Orsini
AU  - Amit Kochar
AU  - Simon Craig
AU  - Stuart Dalziel
AU  - Sarah McNab
AU  - Catherine Quinlan
AU  - Amanda Williams
AU  - Barry Scanlan
AU  - Meredith L Borland
AU  - Andrew Davidson
AU  - Ariel Mace
AU  - Scott Sypek
AU  - Li Huang
AU  - Franz E Babl
AU  - Penelope A Bryant
PY  - 2026
DA  - 2026/11/11
JO  - BMJ Open
DO  - 10.1136/bmjopen-2026-119766
UR  - https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-119766
SN  - 2044-6055
SN  - 2044-6055
ER  -