Efficacy and safety of scaling and root planing for non-alcoholic fatty liver disease.
8 affiliations
- 1Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, 70124, Italy.
- 2Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, 70124, Italy. [email protected].
- 3PTA Trani-ASL BT, Viale Padre Pio, Trani, 76125, Italy.
- 4Department of Forensic Odontology, Section of Legal Medicine, Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.
- 5Department of Economics and Finance, University of Bari "Aldo Moro", Bari, 70124, Italy.
- 6Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, 70124, Italy. [email protected].
- 7Department of Experimental Medicine, University of Salento, Lecce, 73100, Italy.
- 8Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, 70124, Italy. [email protected].
Abstract
Background
To evaluate the effects of scaling and root planing (SRP) on stage of hepatic steatosis measured by abdominal ultrasound (US) in patients affected by Metabolic Associated Fatty Liver Disease (MAFLD) and periodontitis.Methods
In this preliminary retrospective observational study, 205 adult patients affected by equivalent steatosis grade ≥ 1 and periodontitis grade ≥ 1 were included. Patients' baseline characteristics included age, comorbidities and biochemical parameters (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase). Baseline periodontal grade was assessed using periodontal probing depth and grade of hepatic steatosis was assessed using abdominal US. Patients were subjected to periodontal treatment consisting in SRP, in addition to oral hygiene recommendations and the Mediterranean diet. After 6 months, the grade of hepatic steatosis was re-evaluated by an abdominal US. Statistical analysis with Pearson's Chi-squared test was performed. This research received approval from the Ethics Committee.Results
No significant correlation was observed between MAFLD severity and periodontitis stage. At 6 months follow-up, the degree of hepatic steatosis at abdominal US was significantly reduced in 89.8% of patients (p-value < 0.001), regardless of the grade of hepatic steatosis. No adverse events were reported.Conclusion
Non-surgical periodontal treatment consisting in SRP induced a significant short-term reduction of hepatic steatosis at abdominal US. Further research is mandatory to define SRP efficacy and safety in patients with MAFLD, and periodontitis.Trial registration
The Ethics Committee of the University of Bari approved the study (Prot. no. 502 of 16.07.2024 Secretariat of the Local Ethics Committee. Prot. 1737 /CEL - Periodontal Treatment Study"). Local Ethics Committee meeting of July 15, 2024 (Puglia Region Regional Council Resolution No. 712 of May 22, 2023, and Amendment No. 806 of June 12, 2023).
Related
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BibTeX
@article{dipalma2026efficacy,
title = {{Efficacy and safety of scaling and root planing for non-alcoholic fatty liver disease.}},
author = {Gianna Dipalma and Alessio Danilo Inchingolo and Bruno Modesti and Laura Ferrante and Lucia Casamassima and Irma Trilli and Emilio Nuzzolese and Francesco Galante and Caterina Marini and Vito Crincoli and Andrea Palermo and Francesco Inchingolo and Maria Celeste Fatone and Angelo Michele Inchingolo},
journal = {BMC oral health},
year = {2026},
month = aug,
doi = {10.1186/s12903-026-09408-x},
url = {https://europepmc.org/article/MED/42968060},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Efficacy and safety of scaling and root planing for non-alcoholic fatty liver disease.
AU - Gianna Dipalma
AU - Alessio Danilo Inchingolo
AU - Bruno Modesti
AU - Laura Ferrante
AU - Lucia Casamassima
AU - Irma Trilli
AU - Emilio Nuzzolese
AU - Francesco Galante
AU - Caterina Marini
AU - Vito Crincoli
AU - Andrea Palermo
AU - Francesco Inchingolo
AU - Maria Celeste Fatone
AU - Angelo Michele Inchingolo
PY - 2026
DA - 2026/08/05
JO - BMC oral health
DO - 10.1186/s12903-026-09408-x
UR - https://europepmc.org/article/MED/42968060
AB - Background To evaluate the effects of scaling and root planing (SRP) on stage of hepatic steatosis measured by abdominal ultrasound (US) in patients affected by Metabolic Associated Fatty Liver Disease (MAFLD) and periodontitis.Methods In this preliminary retrospective observational study, 205 adult patients affected by equivalent steatosis grade ≥ 1 and periodontitis grade ≥ 1 were included. Patients' baseline characteristics included age, comorbidities and biochemical parameters (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase). Baseline periodontal grade was assessed using periodontal probing depth and grade of hepatic steatosis was assessed using abdominal US. Patients were subjected to periodontal treatment consisting in SRP, in addition to oral hygiene recommendations and the Mediterranean diet. After 6 months, the grade of hepatic steatosis was re-evaluated by an abdominal US. Statistical analysis with Pearson's Chi-squared test was performed. This research received approval from the Ethics Committee.Results No significant correlation was observed between MAFLD severity and periodontitis stage. At 6 months follow-up, the degree of hepatic steatosis at abdominal US was significantly reduced in 89.8% of patients (p-value < 0.001), regardless of the grade of hepatic steatosis. No adverse events were reported.Conclusion Non-surgical periodontal treatment consisting in SRP induced a significant short-term reduction of hepatic steatosis at abdominal US. Further research is mandatory to define SRP efficacy and safety in patients with MAFLD, and periodontitis.Trial registration The Ethics Committee of the University of Bari approved the study (Prot. no. 502 of 16.07.2024 Secretariat of the Local Ethics Committee. Prot. 1737 /CEL - Periodontal Treatment Study"). Local Ethics Committee meeting of July 15, 2024 (Puglia Region Regional Council Resolution No. 712 of May 22, 2023, and Amendment No. 806 of June 12, 2023).
SN - 1472-6831
ER -