CERVICAL CANCER: NATIONAL CLINICAL PRACTICE GUIDELINES FROM THE FRENCH CERVICAL CANCER GUIDELINES GROUP
Abstract
Over the past decade, cervical cancer management has evolved substantially, with major changes in surgical approach, surgical radicality, nodal staging, imaging, radiotherapy techniques, brachytherapy and systemic treatments. To harmonize practice and integrate new evidence into clinically applicable recommendations, the French Cervical Cancer Guidelines Group developed national clinical practice guidelines for the management of patients with cervical cancer. The guideline process was conducted under the auspices of the French National College of Obstetricians and Gynecologists and involved a multidisciplinary expert panel representing the French scientific societies involved in cervical cancer care. Clinical questions were formulated using the PICO framework and addressed the full continuum of care, including initial assessment, imaging, diagnostic conization, surgical nodal staging, treatment, fertility preservation, response assessment, follow-up, recurrence and specific clinical situations. Evidence was reviewed and critically appraised according to the GRADE methodology, and all recommendations were based on the 2018 FIGO staging system. External validation was performed through a two-round Delphi process involving 87 independent reviewers. Overall, 130 PICO questions generated 158 recommendations, including 35 strong and 52 weak recommendations, while no recommendation could be issued for 71 questions. Key practice-changing recommendations include the role of diagnostic conization in early-stage assessment, avoidance of minimally invasive hysterectomy from stage IB1 disease, risk-adapted surgical radicality, sentinel lymph node biopsy with ultrastaging, image-guided brachytherapy after chemoradiotherapy, and integration of PEMBROLIZUMAB in selected locally advanced or metastatic settings.
Related
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- ASSESSMENT OF TREATMENT RESPONSE RESPONSE AND THE ROLE OF COMPLETION SURGERY AFTER CONCURRENT CRTAND BRACHYTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER - A REVIEW FROM THE FRENCH CERVICAL CANCER GUIDELINES GROUP
- POST-TREATMENT SURVEILLANCE AND MANAGEMENT OF RECURRENT CERVICAL CANCER - A REVIEW FROM THE FRENCH CERVICAL CANCER GUIDELINES GROUP
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BibTeX
@article{carcopino2026cervical,
title = {{CERVICAL CANCER: NATIONAL CLINICAL PRACTICE GUIDELINES FROM THE FRENCH CERVICAL CANCER GUIDELINES GROUP}},
author = {Xavier Carcopino and Lobna Ouldamer and Cyrille Huchon and Pauline Asseeva and Henri Azaïs and Sofiane Bendifallah and Jean-Luc Brun and Geoffroy Canlorbe and Cyrus Chargari and Pauline Chauvet and Abel Cordoba and Hélène Courcier and Yohann Dabi and Marion de Berti and Caroline Diguisto and Eva Fuss and Thomas Gaillard and Tristan Gauthier and Witold Gertych and Laurence Gladieff and Olivier Graesslin and Yohan Kerbage and Martin Koskas and Enora Laas and Aymeline Lacorre and Vincent Lavoué and Lise Lecointre and Fabrice Lecuru and François Margueritte and Alejandra Martinez and Paul-Jean Maternowski and Patrice Mathevet and Imane Menouer and Camille Mimoun and Anthony Moureau and Antoine Netter and Charles-André Philip and Pascal Rousset and Claire Sanson and Isabelle Thomassin-Naggara and Cyril Touboul and Jean Lévêque},
journal = {Journal of Gynecology Obstetrics and Human Reproduction},
year = {2026},
month = nov,
doi = {10.1016/j.jogoh.2026.103314},
url = {https://hal.science/hal-05850458v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - CERVICAL CANCER: NATIONAL CLINICAL PRACTICE GUIDELINES FROM THE FRENCH CERVICAL CANCER GUIDELINES GROUP
AU - Xavier Carcopino
AU - Lobna Ouldamer
AU - Cyrille Huchon
AU - Pauline Asseeva
AU - Henri Azaïs
AU - Sofiane Bendifallah
AU - Jean-Luc Brun
AU - Geoffroy Canlorbe
AU - Cyrus Chargari
AU - Pauline Chauvet
AU - Abel Cordoba
AU - Hélène Courcier
AU - Yohann Dabi
AU - Marion de Berti
AU - Caroline Diguisto
AU - Eva Fuss
AU - Thomas Gaillard
AU - Tristan Gauthier
AU - Witold Gertych
AU - Laurence Gladieff
AU - Olivier Graesslin
AU - Yohan Kerbage
AU - Martin Koskas
AU - Enora Laas
AU - Aymeline Lacorre
AU - Vincent Lavoué
AU - Lise Lecointre
AU - Fabrice Lecuru
AU - François Margueritte
AU - Alejandra Martinez
AU - Paul-Jean Maternowski
AU - Patrice Mathevet
AU - Imane Menouer
AU - Camille Mimoun
AU - Anthony Moureau
AU - Antoine Netter
AU - Charles-André Philip
AU - Pascal Rousset
AU - Claire Sanson
AU - Isabelle Thomassin-Naggara
AU - Cyril Touboul
AU - Jean Lévêque
PY - 2026
DA - 2026/11/03
JO - Journal of Gynecology Obstetrics and Human Reproduction
DO - 10.1016/j.jogoh.2026.103314
UR - https://hal.science/hal-05850458v1
AB - Over the past decade, cervical cancer management has evolved substantially, with major changes in surgical approach, surgical radicality, nodal staging, imaging, radiotherapy techniques, brachytherapy and systemic treatments. To harmonize practice and integrate new evidence into clinically applicable recommendations, the French Cervical Cancer Guidelines Group developed national clinical practice guidelines for the management of patients with cervical cancer. The guideline process was conducted under the auspices of the French National College of Obstetricians and Gynecologists and involved a multidisciplinary expert panel representing the French scientific societies involved in cervical cancer care. Clinical questions were formulated using the PICO framework and addressed the full continuum of care, including initial assessment, imaging, diagnostic conization, surgical nodal staging, treatment, fertility preservation, response assessment, follow-up, recurrence and specific clinical situations. Evidence was reviewed and critically appraised according to the GRADE methodology, and all recommendations were based on the 2018 FIGO staging system. External validation was performed through a two-round Delphi process involving 87 independent reviewers. Overall, 130 PICO questions generated 158 recommendations, including 35 strong and 52 weak recommendations, while no recommendation could be issued for 71 questions. Key practice-changing recommendations include the role of diagnostic conization in early-stage assessment, avoidance of minimally invasive hysterectomy from stage IB1 disease, risk-adapted surgical radicality, sentinel lymph node biopsy with ultrastaging, image-guided brachytherapy after chemoradiotherapy, and integration of PEMBROLIZUMAB in selected locally advanced or metastatic settings.
SN - 2468-8495
SN - 2468-7847
ER -