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Peer-reviewedLicence not statedNature Genetics

All of Us diversity and scale yield context-dependent improvements in polygenic prediction

  • Kristin Tsuo1,2,3
  • Zhuozheng Shi4,5
  • Tian Ge6,7,8,9
  • Ravi Mandla4,5
  • Kangcheng Hou10,11,12
  • Yi Ding13
  • Bogdan Paşaniuc4
  • Ying Wang14,15,16
  • Alicia R. Martin17,18,19
19 affiliations
  1. 1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. [email protected]
  2. 2Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  3. 3Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  4. 4Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  5. 5Graduate Program in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA, USA
  6. 6Center for Precision Psychiatry, Massachusetts General Hospital, Boston, MA, USA
  7. 7Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  8. 8Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
  9. 9Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  10. 10Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
  11. 11Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  12. 12Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
  13. 13Division of Population Sciences, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
  14. 14Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. [email protected]
  15. 15Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  16. 16Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  17. 17Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. [email protected]
  18. 18Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
  19. 19Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [email protected]
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Cite

BibTeXRIS
BibTeX
@article{tsuo2026diversity,
  title = {{All of Us diversity and scale yield context-dependent improvements in polygenic prediction}},
  author = {Kristin Tsuo and Zhuozheng Shi and Tian Ge and Ravi Mandla and Kangcheng Hou and Yi Ding and Bogdan Paşaniuc and Ying Wang and Alicia R. Martin},
  journal = {Nature Genetics},
  year = {2026},
  month = sep,
  doi = {10.1038/s41588-026-02734-4},
  url = {https://doi.org/10.1101/2024.08.06.606846},
}
RIS
TY  - JOUR
TI  - All of Us diversity and scale yield context-dependent improvements in polygenic prediction
AU  - Kristin Tsuo
AU  - Zhuozheng Shi
AU  - Tian Ge
AU  - Ravi Mandla
AU  - Kangcheng Hou
AU  - Yi Ding
AU  - Bogdan Paşaniuc
AU  - Ying Wang
AU  - Alicia R. Martin
PY  - 2026
DA  - 2026/09/14
JO  - Nature Genetics
DO  - 10.1038/s41588-026-02734-4
UR  - https://doi.org/10.1101/2024.08.06.606846
SN  - 1061-4036
SN  - 1546-1718
ER  -